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Local variation in femoral neck cortical bone: in vitro measured bone mineral density, geometry and mechanical properties

Local variation in femoral neck cortical bone: in vitro measured bone mineral density, geometry and mechanical properties
Local variation in femoral neck cortical bone: in vitro measured bone mineral density, geometry and mechanical properties
Age- and disease (osteoporotic fractured and osteoarthritic tissue)-related changes in the distribution of cortical bone were examined, using a multimodality approach, including measurement of local density, geometry and mechanical properties, where changes in these properties can give rise to instability and increasing probability of fracture. In contrast to the majority of previously reported research, this study also focuses on the characteristic non-circular femoral neck cross-sectional geometry and variation in bone mineral density (BMD) around the femoral neck. Twenty-two osteoarthritic and 7 osteoporotic femoral neck slices, collected from elective and trauma-related arthroplasty, and 16 cadaveric donor tissue controls were tested mechanically using Reference Point Indentation (BioDent™, Active Life Technologies®, Santa Barbara, CA) and then scanned with in vitro-based radiography intended to replicate the dual-energy X-ray absorptiometry technique. All parameters were measured regionally around the circumference of the femoral neck, allowing examination of spatial variability within the cortical bone. Fractured tissue was less resistant to indentation in the thinner superolateral segment compared to other segments and other groups. BMD around the fractured femoral necks appeared more consistent than that of nonfractured tissue, where BMD was reduced in the superolateral segment for the other groups. Cortical bone was thin in the superolateral segment for all groups except for the osteoarthritic group, and was thicker in the inferomedial segment for both osteoarthritic and fractured groups, resulting in the largest variation in buckling ratio (ratio of cortical bone diameter to cortical bone thickness) around the femoral neck for the fractured group. With age, healthy controls appeared to have lower inferomedial cortical thickness, whereas no significant differences in Reference Point Indentation measurements and density were observed. The study has highlighted several (both quality- and quantity-related) parameters that may be used to improve prediction of fracture risk.
bone mineral density, cortical bone, indentation, mechanical properties, osteoporosis
1094-6950
205-215
Coutts, Louise
90c9e532-5400-4ef8-853f-0e3c311b4f27
Jenkins, T.
e079f477-2bcf-41ea-bb7f-bcbbb5f5c945
Oreffo, R.O.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Dunlop, D.G.
eb03bdad-6a88-4057-acd8-70a9271f629d
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Harvey, N.C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Thurner, P.J.
ab711ddd-784e-48de-aaad-f56aec40f84f
Coutts, Louise
90c9e532-5400-4ef8-853f-0e3c311b4f27
Jenkins, T.
e079f477-2bcf-41ea-bb7f-bcbbb5f5c945
Oreffo, R.O.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Dunlop, D.G.
eb03bdad-6a88-4057-acd8-70a9271f629d
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Harvey, N.C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Thurner, P.J.
ab711ddd-784e-48de-aaad-f56aec40f84f

Coutts, Louise, Jenkins, T., Oreffo, R.O., Dunlop, D.G., Cooper, C., Harvey, N.C. and Thurner, P.J. (2017) Local variation in femoral neck cortical bone: in vitro measured bone mineral density, geometry and mechanical properties. Journal of Clinical Densitometry, 20 (2), 205-215. (doi:10.1016/j.jocd.2015.10.003). (PMID:26710681)

Record type: Article

Abstract

Age- and disease (osteoporotic fractured and osteoarthritic tissue)-related changes in the distribution of cortical bone were examined, using a multimodality approach, including measurement of local density, geometry and mechanical properties, where changes in these properties can give rise to instability and increasing probability of fracture. In contrast to the majority of previously reported research, this study also focuses on the characteristic non-circular femoral neck cross-sectional geometry and variation in bone mineral density (BMD) around the femoral neck. Twenty-two osteoarthritic and 7 osteoporotic femoral neck slices, collected from elective and trauma-related arthroplasty, and 16 cadaveric donor tissue controls were tested mechanically using Reference Point Indentation (BioDent™, Active Life Technologies®, Santa Barbara, CA) and then scanned with in vitro-based radiography intended to replicate the dual-energy X-ray absorptiometry technique. All parameters were measured regionally around the circumference of the femoral neck, allowing examination of spatial variability within the cortical bone. Fractured tissue was less resistant to indentation in the thinner superolateral segment compared to other segments and other groups. BMD around the fractured femoral necks appeared more consistent than that of nonfractured tissue, where BMD was reduced in the superolateral segment for the other groups. Cortical bone was thin in the superolateral segment for all groups except for the osteoarthritic group, and was thicker in the inferomedial segment for both osteoarthritic and fractured groups, resulting in the largest variation in buckling ratio (ratio of cortical bone diameter to cortical bone thickness) around the femoral neck for the fractured group. With age, healthy controls appeared to have lower inferomedial cortical thickness, whereas no significant differences in Reference Point Indentation measurements and density were observed. The study has highlighted several (both quality- and quantity-related) parameters that may be used to improve prediction of fracture risk.

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More information

Accepted/In Press date: 21 October 2015
e-pub ahead of print date: 23 December 2015
Published date: April 2017
Keywords: bone mineral density, cortical bone, indentation, mechanical properties, osteoporosis
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 385394
URI: http://eprints.soton.ac.uk/id/eprint/385394
ISSN: 1094-6950
PURE UUID: cbcf76ff-80e7-4605-9998-b6fd9b37bad1
ORCID for R.O. Oreffo: ORCID iD orcid.org/0000-0001-5995-6726
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709
ORCID for N.C. Harvey: ORCID iD orcid.org/0000-0002-8194-2512
ORCID for P.J. Thurner: ORCID iD orcid.org/0000-0001-7588-9041

Catalogue record

Date deposited: 19 Jan 2016 14:56
Last modified: 17 Dec 2019 01:57

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