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Late preterm birth and neurocognitive performance in late adulthood: a birth cohort study

Late preterm birth and neurocognitive performance in late adulthood: a birth cohort study
Late preterm birth and neurocognitive performance in late adulthood: a birth cohort study
OBJECTIVES: We studied if late preterm birth (34 weeks 0 days–36 weeks 6 days of gestation) is associated with performance on the Consortium to Establish a Registry for Alzheimer’s Disease Neuropsychological Battery (CERAD-NB) in late adulthood and if maximum attained lifetime education moderated these associations.

METHODS: Participants were 919 Finnish men and women born between 1934 and 1944, who participated in the Helsinki Birth Cohort Study. They underwent the CERAD-NB at a mean age of 68.1 years. Data regarding gestational age (late preterm versus term) were extracted from hospital birth records, and educational attainment data were gathered from Statistics Finland.

RESULTS: After adjustment for major confounders, those born late preterm scored lower on word list recognition (mean difference: –0.33 SD; P = .03) than those born at term. Among those who had attained a basic or upper secondary education, late preterm birth was associated with lower scores on word list recognition, constructional praxis, constructional praxis recall, clock drawing, Mini–Mental State Examination, and memory total and CERAD total 2 compound scores (mean differences: >0.40 SD; P values <.05), and had a 2.70 times higher risk of mild cognitive impairment (Mini–Mental State Examination score: <26 points) (P = .02). Among those with tertiary levels of education, late preterm birth was not associated with CERAD-NB scores.

CONCLUSIONS: Our findings offer new insight into the lifelong consequences of late preterm birth, and they add late preterm birth as a novel risk factor to the list of neurocognitive impairment in late adulthood. Our findings also suggest that attained lifetime education may mitigate aging-related neurocognitive impairment, especially among those born late preterm.
education, epidemiology, follow-up studies, mild cognitive impairment, neurocognitive aging, neuropsychology, premature, premature birth, preterm
0031-4005
e818-e825
Heinonen, K.
667793ce-59c1-43d0-9f53-4f7790a9ed94
Eriksson, J.G.
eda300d2-b247-479f-95b9-f12d2c72e92b
Lahti, J.
522c081a-8ed6-476a-b421-f07e9c498ecb
Kajantie, E.
d4e32f85-9988-4b83-b353-012210ea0151
Pesonen, A.K.
edd22dbe-e07d-4212-a476-aaff63f619f5
Tuovinen, S.
3a4d8d1f-1eae-48a2-afcf-65baad23ead8
Osmond, C.
2677bf85-494f-4a78-adf8-580e1b8acb81
Raikkonen, K.
926aba17-06cd-417b-b20f-ae400a2596a6
Heinonen, K.
667793ce-59c1-43d0-9f53-4f7790a9ed94
Eriksson, J.G.
eda300d2-b247-479f-95b9-f12d2c72e92b
Lahti, J.
522c081a-8ed6-476a-b421-f07e9c498ecb
Kajantie, E.
d4e32f85-9988-4b83-b353-012210ea0151
Pesonen, A.K.
edd22dbe-e07d-4212-a476-aaff63f619f5
Tuovinen, S.
3a4d8d1f-1eae-48a2-afcf-65baad23ead8
Osmond, C.
2677bf85-494f-4a78-adf8-580e1b8acb81
Raikkonen, K.
926aba17-06cd-417b-b20f-ae400a2596a6

Heinonen, K., Eriksson, J.G., Lahti, J., Kajantie, E., Pesonen, A.K., Tuovinen, S., Osmond, C. and Raikkonen, K. (2015) Late preterm birth and neurocognitive performance in late adulthood: a birth cohort study. Pediatrics, 135 (4), e818-e825. (doi:10.1542/peds.2014-3556). (PMID:25733746)

Record type: Article

Abstract

OBJECTIVES: We studied if late preterm birth (34 weeks 0 days–36 weeks 6 days of gestation) is associated with performance on the Consortium to Establish a Registry for Alzheimer’s Disease Neuropsychological Battery (CERAD-NB) in late adulthood and if maximum attained lifetime education moderated these associations.

METHODS: Participants were 919 Finnish men and women born between 1934 and 1944, who participated in the Helsinki Birth Cohort Study. They underwent the CERAD-NB at a mean age of 68.1 years. Data regarding gestational age (late preterm versus term) were extracted from hospital birth records, and educational attainment data were gathered from Statistics Finland.

RESULTS: After adjustment for major confounders, those born late preterm scored lower on word list recognition (mean difference: –0.33 SD; P = .03) than those born at term. Among those who had attained a basic or upper secondary education, late preterm birth was associated with lower scores on word list recognition, constructional praxis, constructional praxis recall, clock drawing, Mini–Mental State Examination, and memory total and CERAD total 2 compound scores (mean differences: >0.40 SD; P values <.05), and had a 2.70 times higher risk of mild cognitive impairment (Mini–Mental State Examination score: <26 points) (P = .02). Among those with tertiary levels of education, late preterm birth was not associated with CERAD-NB scores.

CONCLUSIONS: Our findings offer new insight into the lifelong consequences of late preterm birth, and they add late preterm birth as a novel risk factor to the list of neurocognitive impairment in late adulthood. Our findings also suggest that attained lifetime education may mitigate aging-related neurocognitive impairment, especially among those born late preterm.

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More information

Published date: April 2015
Keywords: education, epidemiology, follow-up studies, mild cognitive impairment, neurocognitive aging, neuropsychology, premature, premature birth, preterm
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 385398
URI: http://eprints.soton.ac.uk/id/eprint/385398
ISSN: 0031-4005
PURE UUID: e18355a0-9549-483b-b82d-40a89f819b68
ORCID for C. Osmond: ORCID iD orcid.org/0000-0002-9054-4655

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Date deposited: 19 Jan 2016 15:18
Last modified: 18 Feb 2021 16:45

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Contributors

Author: K. Heinonen
Author: J.G. Eriksson
Author: J. Lahti
Author: E. Kajantie
Author: A.K. Pesonen
Author: S. Tuovinen
Author: C. Osmond ORCID iD
Author: K. Raikkonen

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