Trajectories of body mass index amongst children who develop type 2 diabetes as adults
Trajectories of body mass index amongst children who develop type 2 diabetes as adults
Design and subjects
A total of 13 345 individuals born in Helsinki, Finland between 1934 and 1944 were included in the study. The participants' growth had been recorded in detail during childhood, and 11.7% (n = 1558) had been diagnosed with T2D. We divided the cohort around the median body mass index (BMI) at 11 years. Body composition and glucose tolerance were assessed in a clinical subsample (n = 2003) in adulthood.
Results
Two pathways of growth were associated with T2D. Both began with low weight and BMI at birth. In one, persistent low BMI through infancy was followed by a rapid increase in BMI in childhood. Amongst individuals with a BMI at 11 years above the median value, the odds ratio for T2D associated with a one z-score increase in BMI between 2 and 11 years was 1.31 (95% confidence interval 1.21–1.42, P < 0.001). In the other pathway, low BMI at birth, accompanied by short length at birth, was followed by low BMI in childhood. Most women who developed diabetes followed this trajectory; they developed T2D at a lower BMI and lower fat percentage than women with a BMI above the median at 11 years of age.
Conclusions
Two pathways of early growth trigger T2D. Low fat deposition leading to thinness at birth and during infancy results in fat acquisition during childhood. Reduced linear growth leading to short length at birth is associated with lower body fat percentage in adulthood but increased risk of developing diabetes.
childhood growth, foetal growth, glucose, obesity, type 2 diabetes
219-226
Eriksson, J.G.
eda300d2-b247-479f-95b9-f12d2c72e92b
Kajantie, E.
d4e32f85-9988-4b83-b353-012210ea0151
Lampl, M.
cb9cb5d9-91a5-4315-952e-f3cd6b724085
Osmond, C.
2677bf85-494f-4a78-adf8-580e1b8acb81
August 2015
Eriksson, J.G.
eda300d2-b247-479f-95b9-f12d2c72e92b
Kajantie, E.
d4e32f85-9988-4b83-b353-012210ea0151
Lampl, M.
cb9cb5d9-91a5-4315-952e-f3cd6b724085
Osmond, C.
2677bf85-494f-4a78-adf8-580e1b8acb81
Eriksson, J.G., Kajantie, E., Lampl, M. and Osmond, C.
(2015)
Trajectories of body mass index amongst children who develop type 2 diabetes as adults.
Journal of Internal Medicine, 278 (2), .
(doi:10.1111/joim.12354).
(PMID:25683182)
Abstract
Design and subjects
A total of 13 345 individuals born in Helsinki, Finland between 1934 and 1944 were included in the study. The participants' growth had been recorded in detail during childhood, and 11.7% (n = 1558) had been diagnosed with T2D. We divided the cohort around the median body mass index (BMI) at 11 years. Body composition and glucose tolerance were assessed in a clinical subsample (n = 2003) in adulthood.
Results
Two pathways of growth were associated with T2D. Both began with low weight and BMI at birth. In one, persistent low BMI through infancy was followed by a rapid increase in BMI in childhood. Amongst individuals with a BMI at 11 years above the median value, the odds ratio for T2D associated with a one z-score increase in BMI between 2 and 11 years was 1.31 (95% confidence interval 1.21–1.42, P < 0.001). In the other pathway, low BMI at birth, accompanied by short length at birth, was followed by low BMI in childhood. Most women who developed diabetes followed this trajectory; they developed T2D at a lower BMI and lower fat percentage than women with a BMI above the median at 11 years of age.
Conclusions
Two pathways of early growth trigger T2D. Low fat deposition leading to thinness at birth and during infancy results in fat acquisition during childhood. Reduced linear growth leading to short length at birth is associated with lower body fat percentage in adulthood but increased risk of developing diabetes.
This record has no associated files available for download.
More information
e-pub ahead of print date: 16 March 2015
Published date: August 2015
Keywords:
childhood growth, foetal growth, glucose, obesity, type 2 diabetes
Organisations:
Faculty of Medicine
Identifiers
Local EPrints ID: 385416
URI: http://eprints.soton.ac.uk/id/eprint/385416
ISSN: 0954-6820
PURE UUID: 2f9c7ac2-72eb-4e21-849f-23655f0baab6
Catalogue record
Date deposited: 19 Jan 2016 15:15
Last modified: 15 Mar 2024 02:50
Export record
Altmetrics
Contributors
Author:
J.G. Eriksson
Author:
E. Kajantie
Author:
M. Lampl
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics