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Compartmentalization of immunosenescence: a deeper look at the mucosa

Compartmentalization of immunosenescence: a deeper look at the mucosa
Compartmentalization of immunosenescence: a deeper look at the mucosa
Developments in medical care and living conditions led to an astonishing increase in life-span perspective and subsequently a rise in the old population. This can be seen as a success for public health policies but it also challenges society to adapt, in order to cope with the potentially overwhelming cost for the healthcare system. A fast-growing number of older people lose their ability to live independently because of diseases and disabilities, frailty or cognitive impairment. Many require long-term care, including home-based nursing, communities and hospital-based care. Immunosenescence, an age-related deterioration in immune functions, is considered a major contributory factor for the higher prevalence and severity of infectious diseases and the poor efficacy of vaccination in the elderly. When compared with systemic immunosenescence, alterations in the mucosal immune system with age are less well understood. For this reason, this area deserves more extensive and intensive research and support. In this article, we provide an overview of age-associated changes occurring in systemic immunity and discuss the distinct features of mucosal immunosenescence.
immunosenescence, mucosal immunity, sIgA, microbiota
1389-5729
1-18
Martelli, S.
3a6d7c3d-1972-4b5b-ada0-45f0247a763f
Pender, S.L.
62528b03-ec42-41bb-80fe-48454c2c5242
Larbi, A.
afe38e71-a1e4-47d2-ada9-81e9b7e22c2e
Martelli, S.
3a6d7c3d-1972-4b5b-ada0-45f0247a763f
Pender, S.L.
62528b03-ec42-41bb-80fe-48454c2c5242
Larbi, A.
afe38e71-a1e4-47d2-ada9-81e9b7e22c2e

Martelli, S., Pender, S.L. and Larbi, A. (2015) Compartmentalization of immunosenescence: a deeper look at the mucosa. Biogerontology, 1-18. (doi:10.1007/s10522-015-9628-2). (PMID:26689202)

Record type: Article

Abstract

Developments in medical care and living conditions led to an astonishing increase in life-span perspective and subsequently a rise in the old population. This can be seen as a success for public health policies but it also challenges society to adapt, in order to cope with the potentially overwhelming cost for the healthcare system. A fast-growing number of older people lose their ability to live independently because of diseases and disabilities, frailty or cognitive impairment. Many require long-term care, including home-based nursing, communities and hospital-based care. Immunosenescence, an age-related deterioration in immune functions, is considered a major contributory factor for the higher prevalence and severity of infectious diseases and the poor efficacy of vaccination in the elderly. When compared with systemic immunosenescence, alterations in the mucosal immune system with age are less well understood. For this reason, this area deserves more extensive and intensive research and support. In this article, we provide an overview of age-associated changes occurring in systemic immunity and discuss the distinct features of mucosal immunosenescence.

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More information

Accepted/In Press date: 9 December 2015
e-pub ahead of print date: 21 December 2015
Keywords: immunosenescence, mucosal immunity, sIgA, microbiota
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 385519
URI: https://eprints.soton.ac.uk/id/eprint/385519
ISSN: 1389-5729
PURE UUID: d9b73788-7bee-4b16-b054-a0b2cc2d6b28
ORCID for S.L. Pender: ORCID iD orcid.org/0000-0001-6332-0333

Catalogue record

Date deposited: 20 Jan 2016 13:39
Last modified: 06 Jun 2018 12:51

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Contributors

Author: S. Martelli
Author: S.L. Pender ORCID iD
Author: A. Larbi

University divisions

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