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An optimised detector for in-situ high-resolution NMR in microfluidic devices

An optimised detector for in-situ high-resolution NMR in microfluidic devices
An optimised detector for in-situ high-resolution NMR in microfluidic devices
Integration of high-resolution nuclear magnetic resonance (NMR) spectroscopy with microfluidic lab-on-a-chip devices is challenging due to limited sensitivity and line broadening caused by magnetic susceptibility inhomogeneities. We present a novel double-stripline NMR probe head that accommodates planar microfluidic devices, and obtains the NMR spectrum from a rectangular sample chamber on the chip with a volume of 2 ??l. Finite element analysis was used to jointly optimise the detector and sample volume geometry for sensitivity and RF homogeneity. A prototype of the optimised design has been built, and its properties have been characterised experimentally. The performance in terms of sensitivity and RF homogeneity closely agrees with the numerical predictions. The system reaches a mass limit of detection of 1.57 nmol View the MathML sources, comparing very favourably with other micro-NMR systems. The spectral resolution of this chip/probe system is better than 1.75 Hz at a magnetic field of 7 T, with excellent line shape.
NMR, probes, stripline, microfluidics, transmission line
73-80
Finch, Graeme
98b0a6bd-f2c8-4835-8960-5b9f0d462458
Yilmaz, Ali
71870613-34ac-438b-8450-a3b478a64402
Utz, Marcel
c84ed64c-9e89-4051-af39-d401e423891b
Finch, Graeme
98b0a6bd-f2c8-4835-8960-5b9f0d462458
Yilmaz, Ali
71870613-34ac-438b-8450-a3b478a64402
Utz, Marcel
c84ed64c-9e89-4051-af39-d401e423891b

Finch, Graeme, Yilmaz, Ali and Utz, Marcel (2016) An optimised detector for in-situ high-resolution NMR in microfluidic devices. Journal of Magnetic Resonance, 262, 73-80. (doi:10.1016/j.jmr.2015.11.011).

Record type: Article

Abstract

Integration of high-resolution nuclear magnetic resonance (NMR) spectroscopy with microfluidic lab-on-a-chip devices is challenging due to limited sensitivity and line broadening caused by magnetic susceptibility inhomogeneities. We present a novel double-stripline NMR probe head that accommodates planar microfluidic devices, and obtains the NMR spectrum from a rectangular sample chamber on the chip with a volume of 2 ??l. Finite element analysis was used to jointly optimise the detector and sample volume geometry for sensitivity and RF homogeneity. A prototype of the optimised design has been built, and its properties have been characterised experimentally. The performance in terms of sensitivity and RF homogeneity closely agrees with the numerical predictions. The system reaches a mass limit of detection of 1.57 nmol View the MathML sources, comparing very favourably with other micro-NMR systems. The spectral resolution of this chip/probe system is better than 1.75 Hz at a magnetic field of 7 T, with excellent line shape.

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Accepted/In Press date: 25 November 2015
e-pub ahead of print date: 12 December 2015
Published date: January 2016
Keywords: NMR, probes, stripline, microfluidics, transmission line
Organisations: Chemistry

Identifiers

Local EPrints ID: 385661
URI: http://eprints.soton.ac.uk/id/eprint/385661
PURE UUID: 3550fae3-833d-42bf-bd43-bce9dfb054e5
ORCID for Marcel Utz: ORCID iD orcid.org/0000-0003-2274-9672

Catalogue record

Date deposited: 19 Jan 2016 16:41
Last modified: 17 Dec 2019 01:37

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Contributors

Author: Graeme Finch
Author: Ali Yilmaz
Author: Marcel Utz ORCID iD

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