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Suppression of Aurora-A oncogenic potential by c-Myc downregulation

Suppression of Aurora-A oncogenic potential by c-Myc downregulation
Suppression of Aurora-A oncogenic potential by c-Myc downregulation
The abnormality of serine/threonine kinase Aurora-A is seen in many types of cancers. Although in physiological context it has been shown to play a vital role in cellular mitosis, how this oncogene contributes to tumorigenesis remains unclear. Here we demonstrate that Aurora-A overexpression enhances both the expression level and transcriptional activity of c-Myc. The inhibition of c-Myc expression by RNA interference significantly impaired the oncogenic potential of Aurora-A, resulting in attenuated cellular proliferation and transformation rates as well as fewer centrosomal aberrations. Furthermore, downregulation of c-Myc effectively overcame Aurora-A-induced resistance to cisplatin in esophageal cancer cells. Taken together, our results suggest an important role for c-Myc in mediating the oncogenic activity of Aurora-A, which may in turn allow for future targeting of c-Myc as a potential therapeutic strategy for tumors with Aurora-A overexpression.
aurora kinase, neoplasms, proto-oncogene proteins c-myc, RNA interference
1226-3613
759-767
Yang, Shangbin
eb128acb-bc5c-4c4b-a96a-ae9f3b082b7e
He, Shun
9b356e30-90a0-4c3e-bda2-647139ed62b8
Zhou, Xiaobo
0deca180-bc8a-42d6-b6a6-237e04cae0e1
Liu, Mei
e0020db0-fb1b-43f8-986e-3c8a95fc6435
Zhu, Hongxia
34c74461-aab8-4886-8ed4-f80438fa2083
Wang, Yihua
f5044a95-60a7-42d2-87d6-5f1f789e3a7e
Zhang, Wei
fa6d7061-bfce-48c0-879c-925302213c1a
Yan, Shuang
164b4ca4-28de-4636-8a08-2d9d6d55aa88
Quan, Lanping
75ae7877-e353-41d9-ba4b-c3ad47e5a69c
Bai, Jingfeng
8b58a2e4-57f1-4b02-9ca1-31e8f65c4fde
Xu, Ningzhi
7e2ddae3-ef56-4e9e-9ccb-4fddbcdf045f
Yang, Shangbin
eb128acb-bc5c-4c4b-a96a-ae9f3b082b7e
He, Shun
9b356e30-90a0-4c3e-bda2-647139ed62b8
Zhou, Xiaobo
0deca180-bc8a-42d6-b6a6-237e04cae0e1
Liu, Mei
e0020db0-fb1b-43f8-986e-3c8a95fc6435
Zhu, Hongxia
34c74461-aab8-4886-8ed4-f80438fa2083
Wang, Yihua
f5044a95-60a7-42d2-87d6-5f1f789e3a7e
Zhang, Wei
fa6d7061-bfce-48c0-879c-925302213c1a
Yan, Shuang
164b4ca4-28de-4636-8a08-2d9d6d55aa88
Quan, Lanping
75ae7877-e353-41d9-ba4b-c3ad47e5a69c
Bai, Jingfeng
8b58a2e4-57f1-4b02-9ca1-31e8f65c4fde
Xu, Ningzhi
7e2ddae3-ef56-4e9e-9ccb-4fddbcdf045f

Yang, Shangbin, He, Shun, Zhou, Xiaobo, Liu, Mei, Zhu, Hongxia, Wang, Yihua, Zhang, Wei, Yan, Shuang, Quan, Lanping, Bai, Jingfeng and Xu, Ningzhi (2010) Suppression of Aurora-A oncogenic potential by c-Myc downregulation. Experimental and Molecular Medicine, 42 (11), 759-767. (doi:10.3858/emm.2010.42.11.077).

Record type: Article

Abstract

The abnormality of serine/threonine kinase Aurora-A is seen in many types of cancers. Although in physiological context it has been shown to play a vital role in cellular mitosis, how this oncogene contributes to tumorigenesis remains unclear. Here we demonstrate that Aurora-A overexpression enhances both the expression level and transcriptional activity of c-Myc. The inhibition of c-Myc expression by RNA interference significantly impaired the oncogenic potential of Aurora-A, resulting in attenuated cellular proliferation and transformation rates as well as fewer centrosomal aberrations. Furthermore, downregulation of c-Myc effectively overcame Aurora-A-induced resistance to cisplatin in esophageal cancer cells. Taken together, our results suggest an important role for c-Myc in mediating the oncogenic activity of Aurora-A, which may in turn allow for future targeting of c-Myc as a potential therapeutic strategy for tumors with Aurora-A overexpression.

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More information

Accepted/In Press date: 29 September 2010
e-pub ahead of print date: 1 October 2010
Published date: November 2010
Keywords: aurora kinase, neoplasms, proto-oncogene proteins c-myc, RNA interference
Organisations: Centre for Biological Sciences

Identifiers

Local EPrints ID: 385903
URI: http://eprints.soton.ac.uk/id/eprint/385903
ISSN: 1226-3613
PURE UUID: ab639b85-7242-4b1d-bb0a-b69e4aa6e075
ORCID for Yihua Wang: ORCID iD orcid.org/0000-0001-5561-0648

Catalogue record

Date deposited: 26 Jan 2016 09:48
Last modified: 19 Nov 2019 01:33

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Contributors

Author: Shangbin Yang
Author: Shun He
Author: Xiaobo Zhou
Author: Mei Liu
Author: Hongxia Zhu
Author: Yihua Wang ORCID iD
Author: Wei Zhang
Author: Shuang Yan
Author: Lanping Quan
Author: Jingfeng Bai
Author: Ningzhi Xu

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