?-Catenin/TCF pathway upregulates STAT3 expression in human esophageal squamous cell carcinoma
?-Catenin/TCF pathway upregulates STAT3 expression in human esophageal squamous cell carcinoma
Precise roles of ?-catenin/TCF pathway involved in esophageal tumorigenesis remain elusive. Here we found STAT3 overexpression in esophageal cancer cells and tissues, and its overexpression in esophageal squamous cell carcinoma (ESCC) tissues correlated with ?-catenin cytoplasmic/nuclear accumulation. A functional TCF binding element was detected in STAT3 promoter which specifically bound to TCF4. Transfected ?-catenin induced STAT3 transcriptional activity dose-dependently, and also enhanced STAT3 mRNA and protein levels. These inductions were specifically abolished by dominant-negative TCF4. These results suggest that STAT3 is a target of ?-catenin/TCF pathway and might participate in esophageal tumorigenesis.
?-catenin/TCF, STAT3, ESCC, target gene, overexpression
85-97
Yan, Shuang
164b4ca4-28de-4636-8a08-2d9d6d55aa88
Zhou, Cuiqi
a79cddd5-12f5-41fd-af17-f553062f6d70
Zhang, Wei
fa6d7061-bfce-48c0-879c-925302213c1a
Zhang, Guo
7bce7bd5-04a3-48ac-8330-6f3521fab734
Zhao, Xuejian
11e96f63-d308-4a5d-ab5c-65d5620a7766
Yang, Shangbin
eb128acb-bc5c-4c4b-a96a-ae9f3b082b7e
Wang, Yihua
f5044a95-60a7-42d2-87d6-5f1f789e3a7e
Lu, Ning
8d60125f-c459-4a0e-8d87-c8e0123d40a5
Zhu, Hongxia
34c74461-aab8-4886-8ed4-f80438fa2083
Xu, Ningzhi
7e2ddae3-ef56-4e9e-9ccb-4fddbcdf045f
18 November 2008
Yan, Shuang
164b4ca4-28de-4636-8a08-2d9d6d55aa88
Zhou, Cuiqi
a79cddd5-12f5-41fd-af17-f553062f6d70
Zhang, Wei
fa6d7061-bfce-48c0-879c-925302213c1a
Zhang, Guo
7bce7bd5-04a3-48ac-8330-6f3521fab734
Zhao, Xuejian
11e96f63-d308-4a5d-ab5c-65d5620a7766
Yang, Shangbin
eb128acb-bc5c-4c4b-a96a-ae9f3b082b7e
Wang, Yihua
f5044a95-60a7-42d2-87d6-5f1f789e3a7e
Lu, Ning
8d60125f-c459-4a0e-8d87-c8e0123d40a5
Zhu, Hongxia
34c74461-aab8-4886-8ed4-f80438fa2083
Xu, Ningzhi
7e2ddae3-ef56-4e9e-9ccb-4fddbcdf045f
Yan, Shuang, Zhou, Cuiqi, Zhang, Wei, Zhang, Guo, Zhao, Xuejian, Yang, Shangbin, Wang, Yihua, Lu, Ning, Zhu, Hongxia and Xu, Ningzhi
(2008)
?-Catenin/TCF pathway upregulates STAT3 expression in human esophageal squamous cell carcinoma.
Cancer Letters, 271 (1), .
(doi:10.1016/j.canlet.2008.05.035).
(PMID:18602747)
Abstract
Precise roles of ?-catenin/TCF pathway involved in esophageal tumorigenesis remain elusive. Here we found STAT3 overexpression in esophageal cancer cells and tissues, and its overexpression in esophageal squamous cell carcinoma (ESCC) tissues correlated with ?-catenin cytoplasmic/nuclear accumulation. A functional TCF binding element was detected in STAT3 promoter which specifically bound to TCF4. Transfected ?-catenin induced STAT3 transcriptional activity dose-dependently, and also enhanced STAT3 mRNA and protein levels. These inductions were specifically abolished by dominant-negative TCF4. These results suggest that STAT3 is a target of ?-catenin/TCF pathway and might participate in esophageal tumorigenesis.
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More information
Accepted/In Press date: 23 May 2008
e-pub ahead of print date: 7 July 2008
Published date: 18 November 2008
Keywords:
?-catenin/TCF, STAT3, ESCC, target gene, overexpression
Organisations:
Centre for Biological Sciences
Identifiers
Local EPrints ID: 385911
URI: http://eprints.soton.ac.uk/id/eprint/385911
ISSN: 0304-3835
PURE UUID: a5799a15-c8fc-4800-88a8-75fb3759663f
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Date deposited: 26 Jan 2016 10:13
Last modified: 15 Mar 2024 03:52
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Contributors
Author:
Shuang Yan
Author:
Cuiqi Zhou
Author:
Wei Zhang
Author:
Guo Zhang
Author:
Xuejian Zhao
Author:
Shangbin Yang
Author:
Ning Lu
Author:
Hongxia Zhu
Author:
Ningzhi Xu
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