Knockdown of c-Myc expression by RNAi inhibits MCF-7 breast tumor cells growth in vitro and in vivo
Knockdown of c-Myc expression by RNAi inhibits MCF-7 breast tumor cells growth in vitro and in vivo
c-Myc has a pivotal function in the development of breast cancer. Our data show that decreasing the c-Myc protein level in MCF-7 cells by RNAi could significantly inhibit tumor growth both in vitro and in vivo, and imply the therapeutic potential of RNAi on the treatment of breast cancer by targeting overexpression oncogenes such as c-myc, and c-myc might be a potential therapeutic target for human breast cancer.
c-Myc, gene therapy, MCF-7, RNA interference
R220-R228
Wang, Yi-hua
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Liu, Shuang
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Zhang, Guo
7bce7bd5-04a3-48ac-8330-6f3521fab734
Zhou, Cui-qi
99a27811-7451-48fa-9321-1cbb0ee8b588
Zhu, Hong-xia
ad1b45c0-010f-4249-b960-4be2bc9e0c68
Zhou, Xiao-bo
3d850c99-e22d-4bda-bf68-179d48279cdb
Quan, Lan-ping
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Bai, Jin-feng
60362925-d5b7-4a52-aa0e-ba80792b6ddb
Xu, Ning-zhi
bf61c09c-898d-446b-8d00-dea5ec938797
17 December 2004
Wang, Yi-hua
f5044a95-60a7-42d2-87d6-5f1f789e3a7e
Liu, Shuang
f136b833-cd10-476d-80e2-8e8c69ee69bc
Zhang, Guo
7bce7bd5-04a3-48ac-8330-6f3521fab734
Zhou, Cui-qi
99a27811-7451-48fa-9321-1cbb0ee8b588
Zhu, Hong-xia
ad1b45c0-010f-4249-b960-4be2bc9e0c68
Zhou, Xiao-bo
3d850c99-e22d-4bda-bf68-179d48279cdb
Quan, Lan-ping
a8d4c901-88f9-42ad-8f12-5abf3a966a68
Bai, Jin-feng
60362925-d5b7-4a52-aa0e-ba80792b6ddb
Xu, Ning-zhi
bf61c09c-898d-446b-8d00-dea5ec938797
Wang, Yi-hua, Liu, Shuang, Zhang, Guo, Zhou, Cui-qi, Zhu, Hong-xia, Zhou, Xiao-bo, Quan, Lan-ping, Bai, Jin-feng and Xu, Ning-zhi
(2004)
Knockdown of c-Myc expression by RNAi inhibits MCF-7 breast tumor cells growth in vitro and in vivo.
Breast Cancer Research, 7 (2), .
(doi:10.1186/bcr975).
(PMID:15743499)
Abstract
c-Myc has a pivotal function in the development of breast cancer. Our data show that decreasing the c-Myc protein level in MCF-7 cells by RNAi could significantly inhibit tumor growth both in vitro and in vivo, and imply the therapeutic potential of RNAi on the treatment of breast cancer by targeting overexpression oncogenes such as c-myc, and c-myc might be a potential therapeutic target for human breast cancer.
Text
art%3A10.1186%2Fbcr975.pdf
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Accepted/In Press date: 24 November 2004
Published date: 17 December 2004
Keywords:
c-Myc, gene therapy, MCF-7, RNA interference
Organisations:
Centre for Biological Sciences
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Local EPrints ID: 385923
URI: http://eprints.soton.ac.uk/id/eprint/385923
PURE UUID: 433c6eb5-0e1b-4244-8180-2ba6e47fa44e
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Date deposited: 26 Jan 2016 11:49
Last modified: 15 Mar 2024 03:52
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Contributors
Author:
Shuang Liu
Author:
Guo Zhang
Author:
Cui-qi Zhou
Author:
Hong-xia Zhu
Author:
Xiao-bo Zhou
Author:
Lan-ping Quan
Author:
Jin-feng Bai
Author:
Ning-zhi Xu
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