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Indomethacin induces apoptosis through inhibition of survivin regulated by beta-catenin/TCF4 in human colorectal cancer cells

Indomethacin induces apoptosis through inhibition of survivin regulated by beta-catenin/TCF4 in human colorectal cancer cells
Indomethacin induces apoptosis through inhibition of survivin regulated by beta-catenin/TCF4 in human colorectal cancer cells
Down-regulation of survivin affected by beta-catenin/TCF4 pathway plays an important role in apoptosis induced by NSAIDs indomethacin in HCT116 cells. The beta-catenin/TCF4-survivin pathway may be a potential target in treatment of colon cancer.
737-741
Zhu, Hong-Xia
ad1b45c0-010f-4249-b960-4be2bc9e0c68
Zhang, Guo
7bce7bd5-04a3-48ac-8330-6f3521fab734
Wang, Yi-Hua
f5044a95-60a7-42d2-87d6-5f1f789e3a7e
Zhou, Cui-Qi
99a27811-7451-48fa-9321-1cbb0ee8b588
Bai, Jin-Feng
60362925-d5b7-4a52-aa0e-ba80792b6ddb
Xu, Ning-Zhi
bf61c09c-898d-446b-8d00-dea5ec938797
Zhu, Hong-Xia
ad1b45c0-010f-4249-b960-4be2bc9e0c68
Zhang, Guo
7bce7bd5-04a3-48ac-8330-6f3521fab734
Wang, Yi-Hua
f5044a95-60a7-42d2-87d6-5f1f789e3a7e
Zhou, Cui-Qi
99a27811-7451-48fa-9321-1cbb0ee8b588
Bai, Jin-Feng
60362925-d5b7-4a52-aa0e-ba80792b6ddb
Xu, Ning-Zhi
bf61c09c-898d-446b-8d00-dea5ec938797

Zhu, Hong-Xia, Zhang, Guo, Wang, Yi-Hua, Zhou, Cui-Qi, Bai, Jin-Feng and Xu, Ning-Zhi (2004) Indomethacin induces apoptosis through inhibition of survivin regulated by beta-catenin/TCF4 in human colorectal cancer cells. Ai zheng - Chinese Journal of Cancer, 23 (7), 737-741. (PMID:15248904)

Record type: Article

Abstract

Down-regulation of survivin affected by beta-catenin/TCF4 pathway plays an important role in apoptosis induced by NSAIDs indomethacin in HCT116 cells. The beta-catenin/TCF4-survivin pathway may be a potential target in treatment of colon cancer.

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More information

Published date: July 2004
Organisations: Centre for Biological Sciences
Learn more about Biological Sciences research

Identifiers

Local EPrints ID: 385924
URI: http://eprints.soton.ac.uk/id/eprint/385924
PURE UUID: 9d359ff4-480c-4bda-b608-65f192642699
ORCID for Yi-Hua Wang: ORCID iD orcid.org/0000-0001-5561-0648

Catalogue record

Date deposited: 26 Jan 2016 11:53
Last modified: 23 Jul 2022 02:11

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Contributors

Author: Hong-Xia Zhu
Author: Guo Zhang
Author: Yi-Hua Wang ORCID iD
Author: Cui-Qi Zhou
Author: Jin-Feng Bai
Author: Ning-Zhi Xu

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