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Effects of survivin siRNA on growth, apoptosis and chemosensitivity of ovarian cancer cells SKOV3/DDP

Effects of survivin siRNA on growth, apoptosis and chemosensitivity of ovarian cancer cells SKOV3/DDP
Effects of survivin siRNA on growth, apoptosis and chemosensitivity of ovarian cancer cells SKOV3/DDP
Survivin RNAi can partly suppress the expression of survivin in SKOV3/DDP cells, inhibit the cell proliferation and promote cell apoptosis. Survivin RNAi can enhance the cell sensitivity to apoptosis induced by cisplatin, which implies that survivin RNAi may partly reverse the drug resistance of ovarian cancer. RNAi could be a new approach for gene therapy of cancer.
174-177
Zhang, Xin
788d80a9-6117-4670-81ef-f8ef2d26d30c
Li, Ning
9d42e455-b923-43ee-8214-da4e6be75318
Wang, Yi-hua
365671f5-e933-4538-a2d2-12b32a47071c
Huang, Ying
4d003995-8ee9-4115-9778-a96bf1aa9a02
Xu, Ning-zhi
bf61c09c-898d-446b-8d00-dea5ec938797
Wu, Ling-ying
6fef27a6-8b15-47b2-8d95-2d09f472262d
Zhang, Xin
788d80a9-6117-4670-81ef-f8ef2d26d30c
Li, Ning
9d42e455-b923-43ee-8214-da4e6be75318
Wang, Yi-hua
365671f5-e933-4538-a2d2-12b32a47071c
Huang, Ying
4d003995-8ee9-4115-9778-a96bf1aa9a02
Xu, Ning-zhi
bf61c09c-898d-446b-8d00-dea5ec938797
Wu, Ling-ying
6fef27a6-8b15-47b2-8d95-2d09f472262d

Zhang, Xin, Li, Ning, Wang, Yi-hua, Huang, Ying, Xu, Ning-zhi and Wu, Ling-ying (2009) Effects of survivin siRNA on growth, apoptosis and chemosensitivity of ovarian cancer cells SKOV3/DDP. Zhonghua Zhong Liu Za Zhi [Chinese Journal of Oncology], 31 (3), 174-177. (doi:10.3760/cma.j.issn.0253-3766.2009.03.004). (PMID:19615253)

Record type: Article

Abstract

Survivin RNAi can partly suppress the expression of survivin in SKOV3/DDP cells, inhibit the cell proliferation and promote cell apoptosis. Survivin RNAi can enhance the cell sensitivity to apoptosis induced by cisplatin, which implies that survivin RNAi may partly reverse the drug resistance of ovarian cancer. RNAi could be a new approach for gene therapy of cancer.

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Published date: 23 March 2009
Organisations: Centre for Biological Sciences
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Identifiers

Local EPrints ID: 385926
URI: http://eprints.soton.ac.uk/id/eprint/385926
DOI: doi:10.3760/cma.j.issn.0253-3766.2009.03.004
PURE UUID: 421b9a86-c7ec-48c6-b745-ed716d67dcb6

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Date deposited: 26 Jan 2016 11:59
Last modified: 14 Mar 2024 22:24

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Contributors

Author: Xin Zhang
Author: Ning Li
Author: Yi-hua Wang
Author: Ying Huang
Author: Ning-zhi Xu
Author: Ling-ying Wu

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