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Whole-brain structural topology in adult attention-deficit/hyperactivity disorder: preserved global – disturbed local network organization

Whole-brain structural topology in adult attention-deficit/hyperactivity disorder: preserved global – disturbed local network organization
Whole-brain structural topology in adult attention-deficit/hyperactivity disorder: preserved global – disturbed local network organization
Prior studies demonstrate altered organization of functional brain networks in attention-deficit/hyperactivity disorder (ADHD). However, the structural underpinnings of these functional disturbances are poorly understood. In the current study, we applied a graph-theoretic approach to whole-brain diffusion magnetic resonance imaging data to investigate the organization of structural brain networks in adults with ADHD and unaffected controls using deterministic fiber tractography. Groups did not differ in terms of global network metrics — small-worldness, global efficiency and clustering coefficient. However, there were widespread ADHD-related effects at the nodal level in relation to local efficiency and clustering. The affected nodes included superior occipital, supramarginal, superior temporal, inferior parietal, angular and inferior frontal gyri, as well as putamen, thalamus and posterior cerebellum. Lower local efficiency of left superior temporal and supramarginal gyri was associated with higher ADHD symptom scores. Also greater local clustering of right putamen and lower local clustering of left supramarginal gyrus correlated with ADHD symptom severity. Overall, the findings indicate preserved global but altered local network organization in adult ADHD implicating regions underpinning putative ADHD-related neuropsychological deficits.
attention deficit/hyperactivity disorder, diffusion mri, deterministic tractography, graph theory
2213-1582
506-512
Sidlauskaite, Justina
a50d8acf-707d-4799-b4e7-e71fef98cc7b
Caeyenberghs, Karen
4132d61a-599b-4584-b323-1dbbd9a60bc4
Sonuga-Barke, Edmund
bc80bf95-6cf9-4c76-a09d-eaaf0b717635
Roeyers, Herbert
3554b6b3-e364-4a6a-9e8b-64f5188a6d60
Wiersema, Jan R.
cc91556a-6a9f-4079-b0b8-502bd729b936
Sidlauskaite, Justina
a50d8acf-707d-4799-b4e7-e71fef98cc7b
Caeyenberghs, Karen
4132d61a-599b-4584-b323-1dbbd9a60bc4
Sonuga-Barke, Edmund
bc80bf95-6cf9-4c76-a09d-eaaf0b717635
Roeyers, Herbert
3554b6b3-e364-4a6a-9e8b-64f5188a6d60
Wiersema, Jan R.
cc91556a-6a9f-4079-b0b8-502bd729b936

Sidlauskaite, Justina, Caeyenberghs, Karen, Sonuga-Barke, Edmund, Roeyers, Herbert and Wiersema, Jan R. (2015) Whole-brain structural topology in adult attention-deficit/hyperactivity disorder: preserved global – disturbed local network organization. NeuroImage: Clinical, 9, 506-512. (doi:10.1016/j.nicl.2015.10.001). (PMID:26640763)

Record type: Article

Abstract

Prior studies demonstrate altered organization of functional brain networks in attention-deficit/hyperactivity disorder (ADHD). However, the structural underpinnings of these functional disturbances are poorly understood. In the current study, we applied a graph-theoretic approach to whole-brain diffusion magnetic resonance imaging data to investigate the organization of structural brain networks in adults with ADHD and unaffected controls using deterministic fiber tractography. Groups did not differ in terms of global network metrics — small-worldness, global efficiency and clustering coefficient. However, there were widespread ADHD-related effects at the nodal level in relation to local efficiency and clustering. The affected nodes included superior occipital, supramarginal, superior temporal, inferior parietal, angular and inferior frontal gyri, as well as putamen, thalamus and posterior cerebellum. Lower local efficiency of left superior temporal and supramarginal gyri was associated with higher ADHD symptom scores. Also greater local clustering of right putamen and lower local clustering of left supramarginal gyrus correlated with ADHD symptom severity. Overall, the findings indicate preserved global but altered local network organization in adult ADHD implicating regions underpinning putative ADHD-related neuropsychological deficits.

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Accepted/In Press date: 1 October 2015
e-pub ahead of print date: 13 October 2015
Keywords: attention deficit/hyperactivity disorder, diffusion mri, deterministic tractography, graph theory
Organisations: Clinical Neuroscience

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Local EPrints ID: 385985
URI: http://eprints.soton.ac.uk/id/eprint/385985
ISSN: 2213-1582
PURE UUID: 157c6116-d184-4936-8dfe-75bff4142ed9

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Date deposited: 27 Jan 2016 10:13
Last modified: 14 Mar 2024 22:25

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Contributors

Author: Justina Sidlauskaite
Author: Karen Caeyenberghs
Author: Edmund Sonuga-Barke
Author: Herbert Roeyers
Author: Jan R. Wiersema

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