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Altered intrinsic organisation of brain networks implicated in attentional processes in adult attention-deficit/hyperactivity disorder: a resting-state study of attention, default mode and salience network connectivity

Altered intrinsic organisation of brain networks implicated in attentional processes in adult attention-deficit/hyperactivity disorder: a resting-state study of attention, default mode and salience network connectivity
Altered intrinsic organisation of brain networks implicated in attentional processes in adult attention-deficit/hyperactivity disorder: a resting-state study of attention, default mode and salience network connectivity
Deficits in task-related attentional engagement in attention-deficit/hyperactivity disorder (ADHD) have been hypothesised to be due to altered interrelationships between attention, default mode and salience networks. We examined the intrinsic connectivity during rest within and between these networks. Six-minute resting-state scans were obtained. Using a network-based approach, connectivity within and between the dorsal and ventral attention, the default mode and the salience networks was compared between the ADHD and control group. The ADHD group displayed hyperconnectivity between the two attention networks and within the default mode and ventral attention network. The salience network was hypoconnected to the dorsal attention network. There were trends towards hyperconnectivity within the dorsal attention network and between the salience and ventral attention network in ADHD. Connectivity within and between other networks was unrelated to ADHD. Our findings highlight the altered connectivity within and between attention networks, and between them and the salience network in ADHD. One hypothesis to be tested in future studies is that individuals with ADHD are affected by an imbalance between ventral and dorsal attention systems with the former playing a dominant role during task engagement, making individuals with ADHD highly susceptible to distraction by salient task-irrelevant stimuli.
adhd, connectivity, resting state, brain networks, fMRI
0940-1334
1-9
Sidlauskaite, Justina
a50d8acf-707d-4799-b4e7-e71fef98cc7b
Sonuga-Barke, Edmund
bc80bf95-6cf9-4c76-a09d-eaaf0b717635
Roeyers, Herbert
3554b6b3-e364-4a6a-9e8b-64f5188a6d60
Wiersema, Jan R.
cc91556a-6a9f-4079-b0b8-502bd729b936
Sidlauskaite, Justina
a50d8acf-707d-4799-b4e7-e71fef98cc7b
Sonuga-Barke, Edmund
bc80bf95-6cf9-4c76-a09d-eaaf0b717635
Roeyers, Herbert
3554b6b3-e364-4a6a-9e8b-64f5188a6d60
Wiersema, Jan R.
cc91556a-6a9f-4079-b0b8-502bd729b936

Sidlauskaite, Justina, Sonuga-Barke, Edmund, Roeyers, Herbert and Wiersema, Jan R. (2015) Altered intrinsic organisation of brain networks implicated in attentional processes in adult attention-deficit/hyperactivity disorder: a resting-state study of attention, default mode and salience network connectivity. European Archives of Psychiatry and Clinical Neuroscience, 1-9. (doi:10.1007/s00406-015-0630-0). (PMID:26260900)

Record type: Article

Abstract

Deficits in task-related attentional engagement in attention-deficit/hyperactivity disorder (ADHD) have been hypothesised to be due to altered interrelationships between attention, default mode and salience networks. We examined the intrinsic connectivity during rest within and between these networks. Six-minute resting-state scans were obtained. Using a network-based approach, connectivity within and between the dorsal and ventral attention, the default mode and the salience networks was compared between the ADHD and control group. The ADHD group displayed hyperconnectivity between the two attention networks and within the default mode and ventral attention network. The salience network was hypoconnected to the dorsal attention network. There were trends towards hyperconnectivity within the dorsal attention network and between the salience and ventral attention network in ADHD. Connectivity within and between other networks was unrelated to ADHD. Our findings highlight the altered connectivity within and between attention networks, and between them and the salience network in ADHD. One hypothesis to be tested in future studies is that individuals with ADHD are affected by an imbalance between ventral and dorsal attention systems with the former playing a dominant role during task engagement, making individuals with ADHD highly susceptible to distraction by salient task-irrelevant stimuli.

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More information

Accepted/In Press date: 3 August 2015
e-pub ahead of print date: 11 August 2015
Keywords: adhd, connectivity, resting state, brain networks, fMRI
Organisations: Clinical Neuroscience

Identifiers

Local EPrints ID: 385987
URI: http://eprints.soton.ac.uk/id/eprint/385987
ISSN: 0940-1334
PURE UUID: 55e461a9-8d7b-480e-b8ed-b03b364a9967

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Date deposited: 27 Jan 2016 10:19
Last modified: 14 Mar 2024 22:25

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Contributors

Author: Justina Sidlauskaite
Author: Edmund Sonuga-Barke
Author: Herbert Roeyers
Author: Jan R. Wiersema

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