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Observing single molecules complexing with cucurbit[7]uril through nanogap surface-enhanced Raman spectroscopy

Observing single molecules complexing with cucurbit[7]uril through nanogap surface-enhanced Raman spectroscopy
Observing single molecules complexing with cucurbit[7]uril through nanogap surface-enhanced Raman spectroscopy
In recent years, single molecule sensitivity achievable by surface-enhanced Raman spectroscopy (SERS) has been widely reported. We use this to investigate supramolecular host-guest chemistry with the macrocyclic host cucurbit[7]uril, on a few-to-single molecule level. A nanogap geometry, comprising individual gold nanoparticles on a planar gold surface spaced by a single layer of molecules, gives intense SERS. Plasmonic coupling between the particle and the surface leads to strongly enhanced optical fields in the gap between them, with single molecule sensitivity established using a modification of the well-known bi-analyte method. Changes in the Raman modes of the host molecule are observed when single guests included inside its cavity internally stretch it. Anisotropic intermolecular interactions with the guest are found which show additional distinct features in the Raman modes of the host molecule.
1948-7185
704-710
Sigle, Daniel Oliver
927e4d59-5947-4cf8-807c-9316eb44b667
Kasera, Setu
7f8ee453-2591-4d29-86eb-e0160b941e79
Herrmann, Lars Oliver
67f7dd3f-f282-4bdf-9844-f90a2031cf57
Palma, Aniello
4da96874-d3b5-4be3-8f8f-0a4bf74ce891
de Nijs, Bart
f56f24db-6feb-40e3-bd55-5ff122cc5856
Benz, Felix
97d3bb94-75d5-4f9e-aaa7-494a8bf45a17
Mahajan, Sumeet
b131f40a-479e-4432-b662-19d60d4069e9
Baumberg, Jeremy J.
51423b5f-bdb8-4851-8d50-472253ceb12c
Scherman, Oren A.
4889711e-5279-4211-b6ae-bbe70846e1ef
Sigle, Daniel Oliver
927e4d59-5947-4cf8-807c-9316eb44b667
Kasera, Setu
7f8ee453-2591-4d29-86eb-e0160b941e79
Herrmann, Lars Oliver
67f7dd3f-f282-4bdf-9844-f90a2031cf57
Palma, Aniello
4da96874-d3b5-4be3-8f8f-0a4bf74ce891
de Nijs, Bart
f56f24db-6feb-40e3-bd55-5ff122cc5856
Benz, Felix
97d3bb94-75d5-4f9e-aaa7-494a8bf45a17
Mahajan, Sumeet
b131f40a-479e-4432-b662-19d60d4069e9
Baumberg, Jeremy J.
51423b5f-bdb8-4851-8d50-472253ceb12c
Scherman, Oren A.
4889711e-5279-4211-b6ae-bbe70846e1ef

Sigle, Daniel Oliver, Kasera, Setu, Herrmann, Lars Oliver, Palma, Aniello, de Nijs, Bart, Benz, Felix, Mahajan, Sumeet, Baumberg, Jeremy J. and Scherman, Oren A. (2016) Observing single molecules complexing with cucurbit[7]uril through nanogap surface-enhanced Raman spectroscopy. The Journal of Physical Chemistry Letters, 7 (4), 704-710. (doi:10.1021/acs.jpclett.5b02535).

Record type: Article

Abstract

In recent years, single molecule sensitivity achievable by surface-enhanced Raman spectroscopy (SERS) has been widely reported. We use this to investigate supramolecular host-guest chemistry with the macrocyclic host cucurbit[7]uril, on a few-to-single molecule level. A nanogap geometry, comprising individual gold nanoparticles on a planar gold surface spaced by a single layer of molecules, gives intense SERS. Plasmonic coupling between the particle and the surface leads to strongly enhanced optical fields in the gap between them, with single molecule sensitivity established using a modification of the well-known bi-analyte method. Changes in the Raman modes of the host molecule are observed when single guests included inside its cavity internally stretch it. Anisotropic intermolecular interactions with the guest are found which show additional distinct features in the Raman modes of the host molecule.

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More information

e-pub ahead of print date: 14 January 2016
Organisations: Institute for Life Sciences, Chemical Biology Group

Identifiers

Local EPrints ID: 386025
URI: http://eprints.soton.ac.uk/id/eprint/386025
ISSN: 1948-7185
PURE UUID: 7ca1de9a-31f1-4bcb-9d51-047890641607
ORCID for Sumeet Mahajan: ORCID iD orcid.org/0000-0001-8923-6666

Catalogue record

Date deposited: 27 Jan 2016 11:57
Last modified: 18 Feb 2021 17:09

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