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Association between breast milk fatty acids and HIV-1 transmission through breastfeeding

Association between breast milk fatty acids and HIV-1 transmission through breastfeeding
Association between breast milk fatty acids and HIV-1 transmission through breastfeeding
A residual mother-to-child transmission of HIV through breastfeeding persists despite prophylaxis. We identified breast milk fatty acids (FA) associated with postnatal HIV transmission through breastfeeding in a case-control study. Cases (n=23) were HIV-infected women with an infant who acquired HIV after 6 weeks of age. Controls (n=23) were matched on infant?s age at sample collection. Adjusting for maternal antenatal plasma CD4 T cell count, cis-vaccenic acid (18:1n-7) and eicosatrienoic acid (20:3n-3) were associated with HIV transmission in opposite dose–response manner: OR (tertile 3 versus tertile 1): 10.8 and 0.16, p for trend=0.02 and 0.03, respectively. These fatty acids correlated with HIV RNA load, T helper-1 related cytokines, IL15, IP10, and ?2 microglobulin, positively for cis-vaccenic acid, negatively for eicosatrienoic acid. These results suggested a change in FA synthesis by mammary gland cells leading to increased cis-vaccenic acid in milk of mothers who transmitted HIV to their infant during breastfeeding.
fatty acids n-3 n-7, breast milk, HIV, mother-to-child transmission, breastfeeding, cytokines, immune factors
35-42
Badiou, S.
656d32b8-7472-4e31-9bc9-2267915b164f
Tuaillon, E.
25b18981-72b9-41a8-a991-017b74bc7ae1
Viljoen, J.
a15f94c4-dc7e-4cc3-be82-352ca816d447
Cristol, J.P.
8ea7cbd8-b4d0-4fdb-b469-1298089c3b20
Newell, M L
c6ff99dd-c23b-4fef-a846-a221fe2522b3
Van de Perre, P.
e71f8816-fad7-47ce-9b1b-0ab980dadfb7
Neveu, D.
f505e5c2-82ce-4cde-964d-f794edfa9389
Badiou, S.
656d32b8-7472-4e31-9bc9-2267915b164f
Tuaillon, E.
25b18981-72b9-41a8-a991-017b74bc7ae1
Viljoen, J.
a15f94c4-dc7e-4cc3-be82-352ca816d447
Cristol, J.P.
8ea7cbd8-b4d0-4fdb-b469-1298089c3b20
Newell, M L
c6ff99dd-c23b-4fef-a846-a221fe2522b3
Van de Perre, P.
e71f8816-fad7-47ce-9b1b-0ab980dadfb7
Neveu, D.
f505e5c2-82ce-4cde-964d-f794edfa9389

Badiou, S., Tuaillon, E., Viljoen, J., Cristol, J.P., Newell, M L, Van de Perre, P. and Neveu, D. (2016) Association between breast milk fatty acids and HIV-1 transmission through breastfeeding. Prostaglandins, Leukotrienes and Essential Fatty Acids, 105, 35-42. (doi:10.1016/j.plefa.2015.11.004).

Record type: Article

Abstract

A residual mother-to-child transmission of HIV through breastfeeding persists despite prophylaxis. We identified breast milk fatty acids (FA) associated with postnatal HIV transmission through breastfeeding in a case-control study. Cases (n=23) were HIV-infected women with an infant who acquired HIV after 6 weeks of age. Controls (n=23) were matched on infant?s age at sample collection. Adjusting for maternal antenatal plasma CD4 T cell count, cis-vaccenic acid (18:1n-7) and eicosatrienoic acid (20:3n-3) were associated with HIV transmission in opposite dose–response manner: OR (tertile 3 versus tertile 1): 10.8 and 0.16, p for trend=0.02 and 0.03, respectively. These fatty acids correlated with HIV RNA load, T helper-1 related cytokines, IL15, IP10, and ?2 microglobulin, positively for cis-vaccenic acid, negatively for eicosatrienoic acid. These results suggested a change in FA synthesis by mammary gland cells leading to increased cis-vaccenic acid in milk of mothers who transmitted HIV to their infant during breastfeeding.

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More information

Accepted/In Press date: 27 November 2015
e-pub ahead of print date: 28 December 2015
Published date: February 2016
Keywords: fatty acids n-3 n-7, breast milk, HIV, mother-to-child transmission, breastfeeding, cytokines, immune factors
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 386048
URI: https://eprints.soton.ac.uk/id/eprint/386048
PURE UUID: 25659709-f2c2-4c8b-8b15-da16c626f4d8
ORCID for M L Newell: ORCID iD orcid.org/0000-0002-1074-7699

Catalogue record

Date deposited: 27 Jan 2016 15:22
Last modified: 06 Jun 2018 12:24

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Contributors

Author: S. Badiou
Author: E. Tuaillon
Author: J. Viljoen
Author: J.P. Cristol
Author: M L Newell ORCID iD
Author: P. Van de Perre
Author: D. Neveu

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