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Type 2 diabetes and risk of hospital admission or death for chronic liver diseases

Type 2 diabetes and risk of hospital admission or death for chronic liver diseases
Type 2 diabetes and risk of hospital admission or death for chronic liver diseases
Background & aims: the impact of type 2 diabetes (T2DM) on hospital admissions and deaths due to common chronic liver diseases (CLDs) is uncertain. Our aim was to investigate associations between T2DM and CLDs in a national retrospective cohort study and to investigate the role of sex and socio-economic status (SES).

Methods: we used International Classification of Disease codes to identify incident alcoholic liver disease (ALD), autoimmune liver disease, haemochromatosis, hepatocellular carcinoma, non-alcoholic fatty liver disease (NAFLD) and viral liver disease from linked diabetes, hospital, cancer and death records for people of 40–89 years of age in Scotland 2004–2013. We used quasi Poisson regression to estimate rate ratios (RR).

Results: there were 6667 and 33624 first mentions of CLD in hospital, cancer and death records over ?1.8 and 24 million person-years in people with and without T2DM, respectively. The most common liver disease was ALD among people without diabetes and was NAFLD among people with T2DM. Age-adjusted RR for T2DM compared to the non-diabetic population (95% confidence intervals) varied between 1.27 (1.04–1.55) for autoimmune liver disease and 5.36 (4.41–6.51) for NAFLD. RRs were lower for men than women and for more compared to less deprived populations for both ALD and NAFLD.

Conclusions: T2DM is associated with increased risk of hospital admission or death for all common CLDs and the strength of the association varies by type of CLD, sex and SES. Increasing prevalence of T2DM is likely to result in increasing burden of all CLDs
0168-8278
1358-1364
Wild, S.H.
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Morling, J.R.
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McAllister, D.A.
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Kerssens, J.
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Fischbacher, C.
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Parkes, J.
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Roderick, P.
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Sattar, N.
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Byrne, C.
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Wild, S.H.
eb23a87e-b8da-4f3f-8dab-e02e7b5104aa
Morling, J.R.
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McAllister, D.A.
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Kerssens, J.
0e6d0281-c3fa-4bec-b2a1-8494c6266b50
Fischbacher, C.
fe06f280-78d5-4e02-a761-70bcc9e395e1
Parkes, J.
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Roderick, P.
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Sattar, N.
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Byrne, C.
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Wild, S.H., Morling, J.R., McAllister, D.A., Kerssens, J., Fischbacher, C., Parkes, J., Roderick, P., Sattar, N. and Byrne, C. (2016) Type 2 diabetes and risk of hospital admission or death for chronic liver diseases. Journal of Hepatology, 64 (6), 1358-1364. (doi:10.1016/j.jhep.2016.01.014). (PMID:26812073)

Record type: Article

Abstract

Background & aims: the impact of type 2 diabetes (T2DM) on hospital admissions and deaths due to common chronic liver diseases (CLDs) is uncertain. Our aim was to investigate associations between T2DM and CLDs in a national retrospective cohort study and to investigate the role of sex and socio-economic status (SES).

Methods: we used International Classification of Disease codes to identify incident alcoholic liver disease (ALD), autoimmune liver disease, haemochromatosis, hepatocellular carcinoma, non-alcoholic fatty liver disease (NAFLD) and viral liver disease from linked diabetes, hospital, cancer and death records for people of 40–89 years of age in Scotland 2004–2013. We used quasi Poisson regression to estimate rate ratios (RR).

Results: there were 6667 and 33624 first mentions of CLD in hospital, cancer and death records over ?1.8 and 24 million person-years in people with and without T2DM, respectively. The most common liver disease was ALD among people without diabetes and was NAFLD among people with T2DM. Age-adjusted RR for T2DM compared to the non-diabetic population (95% confidence intervals) varied between 1.27 (1.04–1.55) for autoimmune liver disease and 5.36 (4.41–6.51) for NAFLD. RRs were lower for men than women and for more compared to less deprived populations for both ALD and NAFLD.

Conclusions: T2DM is associated with increased risk of hospital admission or death for all common CLDs and the strength of the association varies by type of CLD, sex and SES. Increasing prevalence of T2DM is likely to result in increasing burden of all CLDs

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__soton.ac.uk_ude_PersonalFiles_Users_lce_mydocuments_Eprints - Prof Byrne_Accepted pubs for Eprints_Journal of Hepatology _Wild S_CDTB et al_Jan 2016_t2dm_CLD_JHEPAT_accepted.pdf - Accepted Manuscript
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Accepted/In Press date: 14 January 2016
e-pub ahead of print date: 23 January 2016
Published date: June 2016
Additional Information: Scottish and Southampton Diabetes and Liver Disease Group; Scottish Diabetes Research Network Epidemiology Group
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 386104
URI: http://eprints.soton.ac.uk/id/eprint/386104
ISSN: 0168-8278
PURE UUID: b91b4215-de63-4b48-b64f-7b2518a0b542
ORCID for J. Parkes: ORCID iD orcid.org/0000-0002-6490-395X
ORCID for P. Roderick: ORCID iD orcid.org/0000-0001-9475-6850
ORCID for C. Byrne: ORCID iD orcid.org/0000-0001-6322-7753

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Date deposited: 29 Jan 2016 12:32
Last modified: 18 Feb 2021 16:53

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Contributors

Author: S.H. Wild
Author: J.R. Morling
Author: D.A. McAllister
Author: J. Kerssens
Author: C. Fischbacher
Author: J. Parkes ORCID iD
Author: P. Roderick ORCID iD
Author: N. Sattar
Author: C. Byrne ORCID iD

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