Intersections between pulmonary development and disease
Intersections between pulmonary development and disease
Recent advances in cellular, molecular, and developmental biology have revolutionized our concepts regarding the process of organogenesis that have important implications for our understanding of both lung formation and pulmonary disease pathogenesis. Pulmonary investigators have long debated whether developmental processes are recapitulated during normal repair of the lung or in the setting of chronic pulmonary diseases. Although the cellular events involved in lung morphogenesis and those causing pulmonary disease are likely to include processes that are distinct, there is increasing evidence that the pathogenesis of many lung disorders involves the same genetic machinery that regulates cell growth,specification, and differentiation during normal lung development.
lung, morphphogenesis, transcription, respiratory
401-406
Whitsett, Jeffrey A.
84fb8fc3-212e-4741-8934-d4083cd6549b
Haitchi, Hans Michael
68dadb29-305d-4236-884f-e9c93f4d78fe
Maeda, Yutaka
93d2b566-1f36-4c02-a1a4-8cc8a7e89e9b
15 August 2011
Whitsett, Jeffrey A.
84fb8fc3-212e-4741-8934-d4083cd6549b
Haitchi, Hans Michael
68dadb29-305d-4236-884f-e9c93f4d78fe
Maeda, Yutaka
93d2b566-1f36-4c02-a1a4-8cc8a7e89e9b
Whitsett, Jeffrey A., Haitchi, Hans Michael and Maeda, Yutaka
(2011)
Intersections between pulmonary development and disease.
American Journal of Respiratory and Critical Care Medicine, 184 (4), .
(doi:10.1164/rccm.201103-0495PP).
(PMID:21642246)
Abstract
Recent advances in cellular, molecular, and developmental biology have revolutionized our concepts regarding the process of organogenesis that have important implications for our understanding of both lung formation and pulmonary disease pathogenesis. Pulmonary investigators have long debated whether developmental processes are recapitulated during normal repair of the lung or in the setting of chronic pulmonary diseases. Although the cellular events involved in lung morphogenesis and those causing pulmonary disease are likely to include processes that are distinct, there is increasing evidence that the pathogenesis of many lung disorders involves the same genetic machinery that regulates cell growth,specification, and differentiation during normal lung development.
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Accepted/In Press date: 31 March 2011
Published date: 15 August 2011
Keywords:
lung, morphphogenesis, transcription, respiratory
Organisations:
Clinical & Experimental Sciences
Identifiers
Local EPrints ID: 386158
URI: http://eprints.soton.ac.uk/id/eprint/386158
ISSN: 1073-449X
PURE UUID: 860a568e-2909-46fc-9a44-85d89f86d436
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Date deposited: 28 Jan 2016 15:21
Last modified: 15 Mar 2024 03:14
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Contributors
Author:
Jeffrey A. Whitsett
Author:
Yutaka Maeda
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