Faster wound healing with topical negative pressure therapy in difficult-to-heal wounds: a prospective randomized controlled trial.
Faster wound healing with topical negative pressure therapy in difficult-to-heal wounds: a prospective randomized controlled trial.
Objective: A randomized clinical trial was conducted to determine the effectiveness and safety of topical negative pressure therapy in patients with difficult-to-heal wounds.
Methods: A total of 24 patients were randomly assigned to either treatment with topical negative pressure therapy or treatment with conventional dressing therapy with sodium hypochlorite. The study end point was 50% reduction in wound volume. The maximum follow-up time was 6 weeks.
Results: The median treatment time to 50% reduction of wound volume in the topical negative pressure group was 2.0 weeks (interquartile range = 1) versus 3.5 weeks (interquartile range = 1.5) in the sodium hypochlorite group (P < 0.001). The unadjusted hazard rate ratio for the time until 50% wound volume reduction was 0.123 (P < 0.001). After adjustment for relevant baseline characteristics in a Cox proportional hazards model treatment group, membership was found as the only and statistically significant indicator for the time to 50% wound volume reduction (hazard rate ratio of 0.117 [P < 0.001]). Subgroup analysis of spinal cord injured patients with severe pressure ulcers showed similar statistically significant results as in the total wound group.
Conclusion: Topical negative pressure resulted in almost 2 times faster wound healing than treatment with sodium hypochlorite, and is safe to use in patients with difficult-to-heal wounds.
topical negative pressure, vacuum-assisted closure, sodium hypochlorite, difficult-to-heal wounds, pressure ulcer
626-631
de Laat, Erik H.E.W.
9b160f42-bded-4e0e-b96d-7375d4bc9e4f
van den Boogaard, Mark H.W.A.
335a5fce-9bca-4a3a-8b5a-10d6cd0e5971
Spauwen, Paul H.M.
2b9d1e00-8ef9-4fa9-9606-d4cc307bf7e4
van Kuppevelt, Dirk H.J.M.
13bde3d9-7967-4073-82b8-88fa19cbabed
van Goor, Harry
6e4f96a5-c749-43b6-a488-6af71f932dc3
Schoonhoven, Lisette
46a2705b-c657-409b-b9da-329d5b1b02de
December 2011
de Laat, Erik H.E.W.
9b160f42-bded-4e0e-b96d-7375d4bc9e4f
van den Boogaard, Mark H.W.A.
335a5fce-9bca-4a3a-8b5a-10d6cd0e5971
Spauwen, Paul H.M.
2b9d1e00-8ef9-4fa9-9606-d4cc307bf7e4
van Kuppevelt, Dirk H.J.M.
13bde3d9-7967-4073-82b8-88fa19cbabed
van Goor, Harry
6e4f96a5-c749-43b6-a488-6af71f932dc3
Schoonhoven, Lisette
46a2705b-c657-409b-b9da-329d5b1b02de
de Laat, Erik H.E.W., van den Boogaard, Mark H.W.A., Spauwen, Paul H.M., van Kuppevelt, Dirk H.J.M., van Goor, Harry and Schoonhoven, Lisette
(2011)
Faster wound healing with topical negative pressure therapy in difficult-to-heal wounds: a prospective randomized controlled trial.
Annals of Plastic Surgery, 67 (6), .
(doi:10.1097/SAP.0b013e31820b3ac1).
(PMID:21629111)
Abstract
Objective: A randomized clinical trial was conducted to determine the effectiveness and safety of topical negative pressure therapy in patients with difficult-to-heal wounds.
Methods: A total of 24 patients were randomly assigned to either treatment with topical negative pressure therapy or treatment with conventional dressing therapy with sodium hypochlorite. The study end point was 50% reduction in wound volume. The maximum follow-up time was 6 weeks.
Results: The median treatment time to 50% reduction of wound volume in the topical negative pressure group was 2.0 weeks (interquartile range = 1) versus 3.5 weeks (interquartile range = 1.5) in the sodium hypochlorite group (P < 0.001). The unadjusted hazard rate ratio for the time until 50% wound volume reduction was 0.123 (P < 0.001). After adjustment for relevant baseline characteristics in a Cox proportional hazards model treatment group, membership was found as the only and statistically significant indicator for the time to 50% wound volume reduction (hazard rate ratio of 0.117 [P < 0.001]). Subgroup analysis of spinal cord injured patients with severe pressure ulcers showed similar statistically significant results as in the total wound group.
Conclusion: Topical negative pressure resulted in almost 2 times faster wound healing than treatment with sodium hypochlorite, and is safe to use in patients with difficult-to-heal wounds.
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Published date: December 2011
Keywords:
topical negative pressure, vacuum-assisted closure, sodium hypochlorite, difficult-to-heal wounds, pressure ulcer
Organisations:
Faculty of Health Sciences
Identifiers
Local EPrints ID: 386280
URI: http://eprints.soton.ac.uk/id/eprint/386280
ISSN: 0148-7043
PURE UUID: 07857fc9-8fce-43c8-94aa-5b5bae7058bb
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Date deposited: 29 Jan 2016 12:44
Last modified: 15 Mar 2024 03:41
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Contributors
Author:
Erik H.E.W. de Laat
Author:
Mark H.W.A. van den Boogaard
Author:
Paul H.M. Spauwen
Author:
Dirk H.J.M. van Kuppevelt
Author:
Harry van Goor
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