Biofabrication of bone tissue: approaches, challenges and translation for bone regeneration
Biofabrication of bone tissue: approaches, challenges and translation for bone regeneration
The rising incidence of bone disorders has resulted in the need for more effective therapies to meet this demand, exacerbated by an increasing ageing population. Bone tissue engineering is seen as a means of developing alternatives to conventional bone grafts for repairing or reconstructing bone defects by combining biomaterials, cells and signalling factors. However, skeletal tissue engineering has not yet achieved full translation into clinical practice as a consequence of several challenges. The use of additive manufacturing techniques for bone biofabrication is seen as a potential solution, with its inherent capability for reproducibility, accuracy and customisation of scaffolds as well as cell and signalling factor delivery. This review highlights the current research in bone biofabrication, the necessary factors for successful bone biofabrication, in addition to the current limitations affecting biofabrication, some of which are a consequence of the limitations of the additive manufacturing technology itself.
skeletal stem cell, osteogenesis, angiogenesis, tissue regeneration, bone tissue engineering, biofabrication
363-382
Tang, Daniel
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Tare, Rahul S.
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Yang, Liang-Yo
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Williams, David F.
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Ou, Keng-Liang
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Oreffo, Richard
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March 2016
Tang, Daniel
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Tare, Rahul S.
587c9db4-e409-4e7c-a02a-677547ab724a
Yang, Liang-Yo
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Williams, David F.
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Ou, Keng-Liang
38fa100d-a804-4a2f-b317-f16156e53ff6
Oreffo, Richard
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Tang, Daniel, Tare, Rahul S., Yang, Liang-Yo, Williams, David F., Ou, Keng-Liang and Oreffo, Richard
(2016)
Biofabrication of bone tissue: approaches, challenges and translation for bone regeneration.
Biomaterials, 83, .
(doi:10.1016/j.biomaterials.2016.01.024).
Abstract
The rising incidence of bone disorders has resulted in the need for more effective therapies to meet this demand, exacerbated by an increasing ageing population. Bone tissue engineering is seen as a means of developing alternatives to conventional bone grafts for repairing or reconstructing bone defects by combining biomaterials, cells and signalling factors. However, skeletal tissue engineering has not yet achieved full translation into clinical practice as a consequence of several challenges. The use of additive manufacturing techniques for bone biofabrication is seen as a potential solution, with its inherent capability for reproducibility, accuracy and customisation of scaffolds as well as cell and signalling factor delivery. This review highlights the current research in bone biofabrication, the necessary factors for successful bone biofabrication, in addition to the current limitations affecting biofabrication, some of which are a consequence of the limitations of the additive manufacturing technology itself.
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Biofabrication of bone tissue approaches challenges and translation for bone regeneration.pdf
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Accepted/In Press date: 1 January 2016
e-pub ahead of print date: 9 January 2016
Published date: March 2016
Keywords:
skeletal stem cell, osteogenesis, angiogenesis, tissue regeneration, bone tissue engineering, biofabrication
Organisations:
Human Development & Health
Identifiers
Local EPrints ID: 386352
URI: http://eprints.soton.ac.uk/id/eprint/386352
ISSN: 0142-9612
PURE UUID: 65b387ff-974f-41b9-877f-45e01c147a64
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Date deposited: 01 Feb 2016 09:59
Last modified: 15 Mar 2024 03:20
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Contributors
Author:
Daniel Tang
Author:
Liang-Yo Yang
Author:
David F. Williams
Author:
Keng-Liang Ou
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