The University of Southampton
University of Southampton Institutional Repository

Biofabrication of bone tissue: approaches, challenges and translation for bone regeneration

Biofabrication of bone tissue: approaches, challenges and translation for bone regeneration
Biofabrication of bone tissue: approaches, challenges and translation for bone regeneration
The rising incidence of bone disorders has resulted in the need for more effective therapies to meet this demand, exacerbated by an increasing ageing population. Bone tissue engineering is seen as a means of developing alternatives to conventional bone grafts for repairing or reconstructing bone defects by combining biomaterials, cells and signalling factors. However, skeletal tissue engineering has not yet achieved full translation into clinical practice as a consequence of several challenges. The use of additive manufacturing techniques for bone biofabrication is seen as a potential solution, with its inherent capability for reproducibility, accuracy and customisation of scaffolds as well as cell and signalling factor delivery. This review highlights the current research in bone biofabrication, the necessary factors for successful bone biofabrication, in addition to the current limitations affecting biofabrication, some of which are a consequence of the limitations of the additive manufacturing technology itself.
skeletal stem cell, osteogenesis, angiogenesis, tissue regeneration, bone tissue engineering, biofabrication
0142-9612
363-382
Tang, Daniel
7c6f7720-2abe-4be7-a51e-fd20d32a26c3
Tare, Rahul S.
587c9db4-e409-4e7c-a02a-677547ab724a
Yang, Liang-Yo
9a51c8e8-0d41-4096-9fad-2746534b8cc4
Williams, David F.
6e138649-57f2-41fb-a9e7-4c24db7fe0bd
Ou, Keng-Liang
38fa100d-a804-4a2f-b317-f16156e53ff6
Oreffo, Richard
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Tang, Daniel
7c6f7720-2abe-4be7-a51e-fd20d32a26c3
Tare, Rahul S.
587c9db4-e409-4e7c-a02a-677547ab724a
Yang, Liang-Yo
9a51c8e8-0d41-4096-9fad-2746534b8cc4
Williams, David F.
6e138649-57f2-41fb-a9e7-4c24db7fe0bd
Ou, Keng-Liang
38fa100d-a804-4a2f-b317-f16156e53ff6
Oreffo, Richard
ff9fff72-6855-4d0f-bfb2-311d0e8f3778

Tang, Daniel, Tare, Rahul S., Yang, Liang-Yo, Williams, David F., Ou, Keng-Liang and Oreffo, Richard (2016) Biofabrication of bone tissue: approaches, challenges and translation for bone regeneration. Biomaterials, 83, 363-382. (doi:10.1016/j.biomaterials.2016.01.024).

Record type: Article

Abstract

The rising incidence of bone disorders has resulted in the need for more effective therapies to meet this demand, exacerbated by an increasing ageing population. Bone tissue engineering is seen as a means of developing alternatives to conventional bone grafts for repairing or reconstructing bone defects by combining biomaterials, cells and signalling factors. However, skeletal tissue engineering has not yet achieved full translation into clinical practice as a consequence of several challenges. The use of additive manufacturing techniques for bone biofabrication is seen as a potential solution, with its inherent capability for reproducibility, accuracy and customisation of scaffolds as well as cell and signalling factor delivery. This review highlights the current research in bone biofabrication, the necessary factors for successful bone biofabrication, in addition to the current limitations affecting biofabrication, some of which are a consequence of the limitations of the additive manufacturing technology itself.

Text
Biofabrication of bone tissue approaches challenges and translation for bone regeneration.pdf - Version of Record
Restricted to Repository staff only
Request a copy

More information

Accepted/In Press date: 1 January 2016
e-pub ahead of print date: 9 January 2016
Published date: March 2016
Keywords: skeletal stem cell, osteogenesis, angiogenesis, tissue regeneration, bone tissue engineering, biofabrication
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 386352
URI: http://eprints.soton.ac.uk/id/eprint/386352
ISSN: 0142-9612
PURE UUID: 65b387ff-974f-41b9-877f-45e01c147a64
ORCID for Rahul S. Tare: ORCID iD orcid.org/0000-0001-8274-8837
ORCID for Richard Oreffo: ORCID iD orcid.org/0000-0001-5995-6726

Catalogue record

Date deposited: 01 Feb 2016 09:59
Last modified: 18 Feb 2021 17:02

Export record

Altmetrics

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×