The University of Southampton
University of Southampton Institutional Repository

Eumycetoma of the hand caused by Leptosphaeria tompkinsii and refractory to medical therapy with voriconazole

Eumycetoma of the hand caused by Leptosphaeria tompkinsii and refractory to medical therapy with voriconazole
Eumycetoma of the hand caused by Leptosphaeria tompkinsii and refractory to medical therapy with voriconazole
We report on the first case of eumycetoma caused by the organism Leptosphaeria tompkinsii to be diagnosed and possibly acquired within the United Kingdom. Conventional culture of fungal grains and surgical tissue specimens was negative and the diagnosis was achieved using panfungal polymerase chain reaction and sequencing technology. Despite limited surgical resection and prolonged antifungal therapy with voriconazole, the patient developed progressive disease with mycetoma bone involvement. This case highlights the usefulness of molecular diagnostic techniques in eumycetoma where organisms may fail to grow with conventional culture or be difficult to identify morphologically. It also reminds us that eumycetoma is a difficult infection to treat and despite optimism regarding the efficacy of the newer triazole antifungals in this condition, treatment failures may still occur.
leptosphaeria tompkinsii, eumycetoma, imported infection, panfungal PCR, voriconazole, treatment failure
0301-486X
311-315
Cartwright, Katharine E.
dd6e6856-5e26-4387-b8f2-7742472da5fa
Clark, Tristan W.
712ec18e-613c-45df-a013-c8a22834e14f
Hussain, Abid M.
66591da2-997c-4328-9103-2973c6877fcf
Wiselka, Martin
8d98fe1b-b442-42ab-9c1a-87372d37ce43
Borman, Andrew
4a203203-514f-4f2a-8a3b-2308c2eeb529
Johnson, Elizabeth M.
72e301c1-5764-4e3f-ba52-fe1fa4a04309
Cartwright, Katharine E.
dd6e6856-5e26-4387-b8f2-7742472da5fa
Clark, Tristan W.
712ec18e-613c-45df-a013-c8a22834e14f
Hussain, Abid M.
66591da2-997c-4328-9103-2973c6877fcf
Wiselka, Martin
8d98fe1b-b442-42ab-9c1a-87372d37ce43
Borman, Andrew
4a203203-514f-4f2a-8a3b-2308c2eeb529
Johnson, Elizabeth M.
72e301c1-5764-4e3f-ba52-fe1fa4a04309

Cartwright, Katharine E., Clark, Tristan W., Hussain, Abid M., Wiselka, Martin, Borman, Andrew and Johnson, Elizabeth M. (2011) Eumycetoma of the hand caused by Leptosphaeria tompkinsii and refractory to medical therapy with voriconazole. Mycopathologia, 172 (4), 311-315. (doi:10.1007/s11046-011-9432-8). (PMID:21567225)

Record type: Article

Abstract

We report on the first case of eumycetoma caused by the organism Leptosphaeria tompkinsii to be diagnosed and possibly acquired within the United Kingdom. Conventional culture of fungal grains and surgical tissue specimens was negative and the diagnosis was achieved using panfungal polymerase chain reaction and sequencing technology. Despite limited surgical resection and prolonged antifungal therapy with voriconazole, the patient developed progressive disease with mycetoma bone involvement. This case highlights the usefulness of molecular diagnostic techniques in eumycetoma where organisms may fail to grow with conventional culture or be difficult to identify morphologically. It also reminds us that eumycetoma is a difficult infection to treat and despite optimism regarding the efficacy of the newer triazole antifungals in this condition, treatment failures may still occur.

Full text not available from this repository.

More information

Accepted/In Press date: 28 April 2011
e-pub ahead of print date: 13 May 2011
Published date: October 2011
Keywords: leptosphaeria tompkinsii, eumycetoma, imported infection, panfungal PCR, voriconazole, treatment failure
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 386401
URI: https://eprints.soton.ac.uk/id/eprint/386401
ISSN: 0301-486X
PURE UUID: 0adb5b61-712b-412f-8acc-532c7219b7f9
ORCID for Tristan W. Clark: ORCID iD orcid.org/0000-0001-6026-5295

Catalogue record

Date deposited: 01 Feb 2016 12:27
Last modified: 06 Jun 2018 12:23

Export record

Altmetrics

Contributors

Author: Katharine E. Cartwright
Author: Abid M. Hussain
Author: Martin Wiselka
Author: Andrew Borman
Author: Elizabeth M. Johnson

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×