An endometrial gene expression signature accurately predicts recurrent implantation failure after IVF
An endometrial gene expression signature accurately predicts recurrent implantation failure after IVF
The primary limiting factor for effective IVF treatment is successful embryo implantation. Recurrent implantation failure (RIF) is a condition whereby couples fail to achieve pregnancy despite consecutive embryo transfers. Here we describe the collection of gene expression profiles from mid-luteal phase endometrial biopsies (n?=?115) from women experiencing RIF and healthy controls. Using a signature discovery set (n?=?81) we identify a signature containing 303 genes predictive of RIF. Independent validation in 34 samples shows that the gene signature predicts RIF with 100% positive predictive value (PPV). The strength of the RIF associated expression signature also stratifies RIF patients into distinct groups with different subsequent implantation success rates. Exploration of the expression changes suggests that RIF is primarily associated with reduced cellular proliferation. The gene signature will be of value in counselling and guiding further treatment of women who fail to conceive upon IVF and suggests new avenues for developing intervention
1-12
Koot, Yvonne E.M.
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van Hooff, Sander R.
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Boomsma, Carolein M.
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van Leenen, Dik
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Groot Koerkamp, Marian J.a.
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Goddijn, Mariette
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Eijkemans, Marinus J.C.
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Fauser, Bart C.J.M.
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Holstege, Frank C.P.
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Macklon, Nick S.
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2016
Koot, Yvonne E.M.
812a2045-e9ef-4c34-9cc8-2c3dfe047828
van Hooff, Sander R.
98c0c9d2-2d17-47f3-8275-e2e422b39f09
Boomsma, Carolein M.
f96a5fb8-630e-4cc3-b310-c345b743abb1
van Leenen, Dik
aca49382-00c4-46cc-908a-c549c09b545c
Groot Koerkamp, Marian J.a.
58e031e2-23b0-43ab-8413-1be0e554feda
Goddijn, Mariette
e4b2971f-b838-4376-b36e-99074a511088
Eijkemans, Marinus J.C.
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Fauser, Bart C.J.M.
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Holstege, Frank C.P.
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Macklon, Nick S.
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Koot, Yvonne E.M., van Hooff, Sander R., Boomsma, Carolein M., van Leenen, Dik, Groot Koerkamp, Marian J.a., Goddijn, Mariette, Eijkemans, Marinus J.C., Fauser, Bart C.J.M., Holstege, Frank C.P. and Macklon, Nick S.
(2016)
An endometrial gene expression signature accurately predicts recurrent implantation failure after IVF.
Scientific Reports, 6, .
(doi:10.1038/srep19411).
Abstract
The primary limiting factor for effective IVF treatment is successful embryo implantation. Recurrent implantation failure (RIF) is a condition whereby couples fail to achieve pregnancy despite consecutive embryo transfers. Here we describe the collection of gene expression profiles from mid-luteal phase endometrial biopsies (n?=?115) from women experiencing RIF and healthy controls. Using a signature discovery set (n?=?81) we identify a signature containing 303 genes predictive of RIF. Independent validation in 34 samples shows that the gene signature predicts RIF with 100% positive predictive value (PPV). The strength of the RIF associated expression signature also stratifies RIF patients into distinct groups with different subsequent implantation success rates. Exploration of the expression changes suggests that RIF is primarily associated with reduced cellular proliferation. The gene signature will be of value in counselling and guiding further treatment of women who fail to conceive upon IVF and suggests new avenues for developing intervention
Text
Sci Rep paper Jan 2016.pdf
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Accepted/In Press date: 11 December 2015
e-pub ahead of print date: 22 January 2016
Published date: 2016
Organisations:
Human Development & Health
Identifiers
Local EPrints ID: 386409
URI: http://eprints.soton.ac.uk/id/eprint/386409
PURE UUID: 1b3daa9c-f6f1-4b4e-9260-7edf917c0e59
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Date deposited: 25 Jan 2016 14:31
Last modified: 14 Mar 2024 22:31
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Contributors
Author:
Yvonne E.M. Koot
Author:
Sander R. van Hooff
Author:
Carolein M. Boomsma
Author:
Dik van Leenen
Author:
Marian J.a. Groot Koerkamp
Author:
Mariette Goddijn
Author:
Marinus J.C. Eijkemans
Author:
Bart C.J.M. Fauser
Author:
Frank C.P. Holstege
Author:
Nick S. Macklon
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