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An endometrial gene expression signature accurately predicts recurrent implantation failure after IVF

An endometrial gene expression signature accurately predicts recurrent implantation failure after IVF
An endometrial gene expression signature accurately predicts recurrent implantation failure after IVF
The primary limiting factor for effective IVF treatment is successful embryo implantation. Recurrent implantation failure (RIF) is a condition whereby couples fail to achieve pregnancy despite consecutive embryo transfers. Here we describe the collection of gene expression profiles from mid-luteal phase endometrial biopsies (n?=?115) from women experiencing RIF and healthy controls. Using a signature discovery set (n?=?81) we identify a signature containing 303 genes predictive of RIF. Independent validation in 34 samples shows that the gene signature predicts RIF with 100% positive predictive value (PPV). The strength of the RIF associated expression signature also stratifies RIF patients into distinct groups with different subsequent implantation success rates. Exploration of the expression changes suggests that RIF is primarily associated with reduced cellular proliferation. The gene signature will be of value in counselling and guiding further treatment of women who fail to conceive upon IVF and suggests new avenues for developing intervention
1-12
Koot, Yvonne E.M.
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van Hooff, Sander R.
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Boomsma, Carolein M.
f96a5fb8-630e-4cc3-b310-c345b743abb1
van Leenen, Dik
aca49382-00c4-46cc-908a-c549c09b545c
Groot Koerkamp, Marian J.a.
58e031e2-23b0-43ab-8413-1be0e554feda
Goddijn, Mariette
e4b2971f-b838-4376-b36e-99074a511088
Eijkemans, Marinus J.C.
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Fauser, Bart C.J.M.
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Holstege, Frank C.P.
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Macklon, Nick S.
7db1f4fc-a9f6-431f-a1f2-297bb8c9fb7e
Koot, Yvonne E.M.
812a2045-e9ef-4c34-9cc8-2c3dfe047828
van Hooff, Sander R.
98c0c9d2-2d17-47f3-8275-e2e422b39f09
Boomsma, Carolein M.
f96a5fb8-630e-4cc3-b310-c345b743abb1
van Leenen, Dik
aca49382-00c4-46cc-908a-c549c09b545c
Groot Koerkamp, Marian J.a.
58e031e2-23b0-43ab-8413-1be0e554feda
Goddijn, Mariette
e4b2971f-b838-4376-b36e-99074a511088
Eijkemans, Marinus J.C.
f95640f3-5107-4b1b-b924-ebac8a334321
Fauser, Bart C.J.M.
0edf5e0f-12db-4ca9-bf9c-00e85b7f4a3e
Holstege, Frank C.P.
a0e41716-b7a7-4f9f-acd7-f15253e13a3c
Macklon, Nick S.
7db1f4fc-a9f6-431f-a1f2-297bb8c9fb7e

Koot, Yvonne E.M., van Hooff, Sander R., Boomsma, Carolein M., van Leenen, Dik, Groot Koerkamp, Marian J.a., Goddijn, Mariette, Eijkemans, Marinus J.C., Fauser, Bart C.J.M., Holstege, Frank C.P. and Macklon, Nick S. (2016) An endometrial gene expression signature accurately predicts recurrent implantation failure after IVF. Scientific Reports, 6, 1-12. (doi:10.1038/srep19411).

Record type: Article

Abstract

The primary limiting factor for effective IVF treatment is successful embryo implantation. Recurrent implantation failure (RIF) is a condition whereby couples fail to achieve pregnancy despite consecutive embryo transfers. Here we describe the collection of gene expression profiles from mid-luteal phase endometrial biopsies (n?=?115) from women experiencing RIF and healthy controls. Using a signature discovery set (n?=?81) we identify a signature containing 303 genes predictive of RIF. Independent validation in 34 samples shows that the gene signature predicts RIF with 100% positive predictive value (PPV). The strength of the RIF associated expression signature also stratifies RIF patients into distinct groups with different subsequent implantation success rates. Exploration of the expression changes suggests that RIF is primarily associated with reduced cellular proliferation. The gene signature will be of value in counselling and guiding further treatment of women who fail to conceive upon IVF and suggests new avenues for developing intervention

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Accepted/In Press date: 11 December 2015
e-pub ahead of print date: 22 January 2016
Published date: 2016
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 386409
URI: http://eprints.soton.ac.uk/id/eprint/386409
PURE UUID: 1b3daa9c-f6f1-4b4e-9260-7edf917c0e59

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Date deposited: 25 Jan 2016 14:31
Last modified: 16 Dec 2019 20:08

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Contributors

Author: Yvonne E.M. Koot
Author: Sander R. van Hooff
Author: Carolein M. Boomsma
Author: Dik van Leenen
Author: Marian J.a. Groot Koerkamp
Author: Mariette Goddijn
Author: Marinus J.C. Eijkemans
Author: Bart C.J.M. Fauser
Author: Frank C.P. Holstege
Author: Nick S. Macklon

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