Perenosins: a new class of anion transporter with anti-cancer activity

Van Rossom, Wim, Asby, Daniel J., Tavassoli, Ali and Gale, Philip A. (2016) Perenosins: a new class of anion transporter with anti-cancer activity. Organic & Biomolecular Chemistry. (doi:10.1039/C6OB00002A).

Record type: Article

Abstract

A new class of anion transporter named ‘perenosins’ consisting of a pyrrole linked through an imine to either an indole, benzimidazole or indazole is reported. The indole containing members of the perenosin family function as effective transmembrane Cl?/NO3? antiporters and HCl cotransporters in a manner similar to the prodigiosenes. The compounds reduce the viability of MDA-MB-231 and MCF-7.

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More information

Accepted/In Press date: 26 January 2016

e-pub ahead of print date: 1 February 2016

Related URLs:

http://eprints.soton.ac.uk/386610

Organisations: Organic Chemistry: SCF

Identifiers

Local EPrints ID: 386512

URI: http://eprints.soton.ac.uk/id/eprint/386512

DOI: doi:10.1039/C6OB00002A

ISSN: 1477-0520

PURE UUID: 65f145f0-b00c-42e9-bfef-8b706c927f92

ORCID for Ali Tavassoli:

orcid.org/0000-0002-7420-5063

ORCID for Philip A. Gale:

orcid.org/0000-0001-9751-4910

Catalogue record

Date deposited: 01 Feb 2016 17:05

Last modified: 15 Mar 2024 03:26

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Contributors

Author: Wim Van Rossom

Author: Daniel J. Asby

Author: Ali Tavassoli

Author: Philip A. Gale

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