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Iron and a mixture of DHA and EPA supplementation, alone and in combination, affect bioactive lipid signalling and morbidity of iron deficient South African school children in a two-by-two randomised controlled trial

Iron and a mixture of DHA and EPA supplementation, alone and in combination, affect bioactive lipid signalling and morbidity of iron deficient South African school children in a two-by-two randomised controlled trial
Iron and a mixture of DHA and EPA supplementation, alone and in combination, affect bioactive lipid signalling and morbidity of iron deficient South African school children in a two-by-two randomised controlled trial
We recently reported that iron supplementation increased respiratory morbidity in iron deficient South African children. This increase, however, was attenuated when iron was provided in combination with a mixture of DHA/EPA. To explore potential underlying mechanisms, we examined the effects of iron and DHA/EPA, alone and in combination, on plasma lipid-derived immune modulator concentrations and related gene expression in peripheral blood mononuclear cells (PBMC). DHA/EPA decreased inflammatory 12-hydroxyeicosatetraenoic acid and tended to increase anti-inflammatory and pro-resolving 17-hydroxydocosahexaenoic acid (17-HDHA), while iron decreased 17-HDHA. However, in combination with iron, the anti-inflammatory effect of DHA/EPA was maintained. These biochemical changes may explain the prevention of iron-induced respiratory morbidity that we observed when iron was supplemented in combination with DHA/EPA during the 8.5 month randomised controlled trial and might lead to a safer approach of delivering iron supplementation. The study was registered at clinicaltrials.gov as NCT01092377.
omega-3 fatty acids, lipid-derived immune modulators, gene expression, inflammation, oxidative stress, morbidity
15-25
Malan, L.
428f12c5-77fd-48f9-a708-f185feec3528
Baumgartner, J.
eeefaa71-00bb-4d37-b22d-7276176a0092
Zandberg, L.
81056836-f3ce-49bd-9a0e-cd5739e7c138
Calder, P.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Smuts, C.M.
a1211cee-c179-4a6c-b127-014ae8cf2f87
Malan, L.
428f12c5-77fd-48f9-a708-f185feec3528
Baumgartner, J.
eeefaa71-00bb-4d37-b22d-7276176a0092
Zandberg, L.
81056836-f3ce-49bd-9a0e-cd5739e7c138
Calder, P.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Smuts, C.M.
a1211cee-c179-4a6c-b127-014ae8cf2f87

Malan, L., Baumgartner, J., Zandberg, L., Calder, P. and Smuts, C.M. (2016) Iron and a mixture of DHA and EPA supplementation, alone and in combination, affect bioactive lipid signalling and morbidity of iron deficient South African school children in a two-by-two randomised controlled trial. Prostaglandins, Leukotrienes and Essential Fatty Acids, 105, 15-25. (doi:10.1016/j.plefa.2015.12.005).

Record type: Article

Abstract

We recently reported that iron supplementation increased respiratory morbidity in iron deficient South African children. This increase, however, was attenuated when iron was provided in combination with a mixture of DHA/EPA. To explore potential underlying mechanisms, we examined the effects of iron and DHA/EPA, alone and in combination, on plasma lipid-derived immune modulator concentrations and related gene expression in peripheral blood mononuclear cells (PBMC). DHA/EPA decreased inflammatory 12-hydroxyeicosatetraenoic acid and tended to increase anti-inflammatory and pro-resolving 17-hydroxydocosahexaenoic acid (17-HDHA), while iron decreased 17-HDHA. However, in combination with iron, the anti-inflammatory effect of DHA/EPA was maintained. These biochemical changes may explain the prevention of iron-induced respiratory morbidity that we observed when iron was supplemented in combination with DHA/EPA during the 8.5 month randomised controlled trial and might lead to a safer approach of delivering iron supplementation. The study was registered at clinicaltrials.gov as NCT01092377.

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More information

Accepted/In Press date: 5 December 2015
e-pub ahead of print date: 22 December 2015
Published date: February 2016
Keywords: omega-3 fatty acids, lipid-derived immune modulators, gene expression, inflammation, oxidative stress, morbidity
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 386753
URI: http://eprints.soton.ac.uk/id/eprint/386753
PURE UUID: 294c34b1-b43d-496e-b5c0-b2658bcce786
ORCID for P. Calder: ORCID iD orcid.org/0000-0002-6038-710X

Catalogue record

Date deposited: 04 Feb 2016 09:21
Last modified: 11 Mar 2021 02:35

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