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Intelligence in childhood and atherosclerosis of the carotid and peripheral arteries in later life: the Lothian Birth Cohort 1936

Intelligence in childhood and atherosclerosis of the carotid and peripheral arteries in later life: the Lothian Birth Cohort 1936
Intelligence in childhood and atherosclerosis of the carotid and peripheral arteries in later life: the Lothian Birth Cohort 1936
Objective

There is some evidence that people who score higher on tests of intelligence in childhood have lower carotid intima-media thickness and higher ankle brachial index in middle age. These findings need replicating in other, older populations. We investigated the prospective relationship between intelligence in childhood and atherosclerosis in the carotid and peripheral arteries at age 73 years.

Methods

Participants were 713 members of the Lothian Birth Cohort 1936 whose intelligence was assessed at age 11 years. At age 73 years, carotid intima-media thickness and degree of stenosis were measured using ultrasound imaging; ankle-brachial index was measured using Doppler ultrasound.

Results

There were no significant associations between intelligence at age 11 and measures of atherosclerosis at age 73. In age- and sex-adjusted analyses, for a standard deviation higher score in intelligence, intima-media thickness (x 10) was lower by 0.07 (-0.20, 0.06) mm and ankle brachial index (x 10) was lower by 0.09 (-0.24, 0.07); odds ratios for having carotid stenosis >25% or peripheral arterial disease were 0.98 (0.82, 1.16) and 1.05 (0.81, 1.36) respectively.

Conclusion

In this study of people aged 73 years, higher childhood intelligence was not associated with reduced risk of atherosclerosis in the carotid or peripheral arteries.
1932-6203
1-7
Gale, C.R.
5bb2abb3-7b53-42d6-8aa7-817e193140c8
Eadie, E.
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Thomas, A.
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Bastin, M.E.
e4c83f00-12fc-43b0-af6a-5f282aa8167d
Starr, J.M.
efba1461-fa5a-4669-9801-d6530f48d01c
Wardlaw, J.
c851a27a-53b3-4832-8666-47421632e9ed
Deary, I.J.
e3403cfe-eb5b-4941-903d-87ef0db89c60
Gale, C.R.
5bb2abb3-7b53-42d6-8aa7-817e193140c8
Eadie, E.
6b4a2307-6a2a-4d0f-9451-0378155d7e15
Thomas, A.
9748d291-b6a0-4ba4-8010-4726987823b6
Bastin, M.E.
e4c83f00-12fc-43b0-af6a-5f282aa8167d
Starr, J.M.
efba1461-fa5a-4669-9801-d6530f48d01c
Wardlaw, J.
c851a27a-53b3-4832-8666-47421632e9ed
Deary, I.J.
e3403cfe-eb5b-4941-903d-87ef0db89c60

Gale, C.R., Eadie, E., Thomas, A., Bastin, M.E., Starr, J.M., Wardlaw, J. and Deary, I.J. (2015) Intelligence in childhood and atherosclerosis of the carotid and peripheral arteries in later life: the Lothian Birth Cohort 1936. PLoS ONE, 10 (4), 1-7. (doi:10.1371/journal.pone.0125280). (PMID:25915652)

Record type: Article

Abstract

Objective

There is some evidence that people who score higher on tests of intelligence in childhood have lower carotid intima-media thickness and higher ankle brachial index in middle age. These findings need replicating in other, older populations. We investigated the prospective relationship between intelligence in childhood and atherosclerosis in the carotid and peripheral arteries at age 73 years.

Methods

Participants were 713 members of the Lothian Birth Cohort 1936 whose intelligence was assessed at age 11 years. At age 73 years, carotid intima-media thickness and degree of stenosis were measured using ultrasound imaging; ankle-brachial index was measured using Doppler ultrasound.

Results

There were no significant associations between intelligence at age 11 and measures of atherosclerosis at age 73. In age- and sex-adjusted analyses, for a standard deviation higher score in intelligence, intima-media thickness (x 10) was lower by 0.07 (-0.20, 0.06) mm and ankle brachial index (x 10) was lower by 0.09 (-0.24, 0.07); odds ratios for having carotid stenosis >25% or peripheral arterial disease were 0.98 (0.82, 1.16) and 1.05 (0.81, 1.36) respectively.

Conclusion

In this study of people aged 73 years, higher childhood intelligence was not associated with reduced risk of atherosclerosis in the carotid or peripheral arteries.

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More information

Accepted/In Press date: 22 March 2015
Published date: 27 April 2015
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 386839
URI: http://eprints.soton.ac.uk/id/eprint/386839
ISSN: 1932-6203
PURE UUID: ad2815d7-7df8-40cf-ac1e-6474ef469486
ORCID for C.R. Gale: ORCID iD orcid.org/0000-0002-3361-8638

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Date deposited: 03 Feb 2016 11:29
Last modified: 18 Feb 2021 16:44

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Contributors

Author: C.R. Gale ORCID iD
Author: E. Eadie
Author: A. Thomas
Author: M.E. Bastin
Author: J.M. Starr
Author: J. Wardlaw
Author: I.J. Deary

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