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Pharmaceutical powder dispensing by ultrasonic vibration dosing system

Pharmaceutical powder dispensing by ultrasonic vibration dosing system
Pharmaceutical powder dispensing by ultrasonic vibration dosing system
Powder technology is one of the most important parts in manufacturing industry when materials applied in large quantities of solid particles. Dispensing technology for powders can significantly improve operation efficiency in manufacturing processes. The powder dispensing technologies have a broad range of applications. The powders exhibit different flow behaviours due to different physical properties. This project aims to reveal the dispensing mechanism and pharmaceutical powder flow behaviour in a designed dispensing hopper under the ultrasonic mechanical vibration, and to develop a powder dosing system to achieve the precise dispensing of pharmaceutical powders.

The experimental work focuses on the dispensing device design and pharmaceutical powder dispensing tests by using ultrasonic vibration dosing system. The experimental results indicate that the ultrasonic vibration dosing system is capable of fast (less than one second) and precise (RSD<5%) pharmaceutical powder dispensing in small-dose (milligram scale) and large-dose (gram scale). A dome-control mechanism is identified in the ultrasonic vibration dispensing process. Powder dome formed in the dispensing hopper as a “valve” of powder flow under the ultrasonic vibration. The dispensing results represent that the parameters of dispensing hopper, i.e. orifice size, hopper angle, and working voltage signal, i.e. vibration duration, are the critical factors for the powder flow rate and dosage uniformity of the dispensing.

Additionally, the working voltage signal properties and mechanical vibration performance are investigated in the ultrasonic vibration dispensing device by using the digital oscilloscope and the 3D scanning vibrometer.
Pan, Lin
816bd8e2-c752-4066-bb12-9e9f7025b669
Pan, Lin
816bd8e2-c752-4066-bb12-9e9f7025b669
Yang, Shoufeng
e0018adf-8123-4a54-b8dd-306c10ca48f1

(2015) Pharmaceutical powder dispensing by ultrasonic vibration dosing system. University of Southampton, Faculty of Engineering and the Environment, Doctoral Thesis, 175pp.

Record type: Thesis (Doctoral)

Abstract

Powder technology is one of the most important parts in manufacturing industry when materials applied in large quantities of solid particles. Dispensing technology for powders can significantly improve operation efficiency in manufacturing processes. The powder dispensing technologies have a broad range of applications. The powders exhibit different flow behaviours due to different physical properties. This project aims to reveal the dispensing mechanism and pharmaceutical powder flow behaviour in a designed dispensing hopper under the ultrasonic mechanical vibration, and to develop a powder dosing system to achieve the precise dispensing of pharmaceutical powders.

The experimental work focuses on the dispensing device design and pharmaceutical powder dispensing tests by using ultrasonic vibration dosing system. The experimental results indicate that the ultrasonic vibration dosing system is capable of fast (less than one second) and precise (RSD<5%) pharmaceutical powder dispensing in small-dose (milligram scale) and large-dose (gram scale). A dome-control mechanism is identified in the ultrasonic vibration dispensing process. Powder dome formed in the dispensing hopper as a “valve” of powder flow under the ultrasonic vibration. The dispensing results represent that the parameters of dispensing hopper, i.e. orifice size, hopper angle, and working voltage signal, i.e. vibration duration, are the critical factors for the powder flow rate and dosage uniformity of the dispensing.

Additionally, the working voltage signal properties and mechanical vibration performance are investigated in the ultrasonic vibration dispensing device by using the digital oscilloscope and the 3D scanning vibrometer.

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PhD Thesis by Lin Pan (Final).pdf - Other
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More information

Published date: 1 August 2015
Organisations: University of Southampton, Engineering Mats & Surface Engineerg Gp

Identifiers

Local EPrints ID: 386902
URI: http://eprints.soton.ac.uk/id/eprint/386902
PURE UUID: d606b083-4cb1-4a6e-ac01-f052808bf8f2
ORCID for Shoufeng Yang: ORCID iD orcid.org/0000-0002-3888-3211

Catalogue record

Date deposited: 09 Feb 2016 16:47
Last modified: 18 Feb 2019 05:01

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