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Ischemic heart disease is associated with lower cortical volumetric bone mineral density of distal radius

Ischemic heart disease is associated with lower cortical volumetric bone mineral density of distal radius
Ischemic heart disease is associated with lower cortical volumetric bone mineral density of distal radius
Summary: In this study, high-resolution peripheral quantitative computed tomography (HR-pQCT) was used to investigate geometric, volumetric and microstructural parameters at the distal radius and at the distal tibia in participants with ischaemic heart disease. We found that, compared with participants without ischaemic heart disease, they had substantially lower cortical volumetric bone mineral density (BMD) at the distal radius.

Introduction:HR-pQCT captures novel aspects of bone geometry and volumetric bone mineral density (vBMD) and offers the ability to measure bone microarchitecture, but data relating measures obtained from this technique in patients with ischemic heart disease (IHD) are lacking.

Methods: Here, we report an analysis from the Hertfordshire Cohort Study, where we were able to study associations between measures obtained from HR-pQCT of distal radius and distal tibia in 350 participants (184 men and 166 women) aged 71.5–80.5 years with or without IHD (e.g. heart attack, angina or heart failure; n?=?75 and n?=?275, respectively).

Results:Analyses for all participants (men and women together) revealed that cortical vBMD (Ct.vBMD) was lower (p?<?0.001) and cortical thickness (Ct.th) was not different (p?=?0.519), whereas cortical porosity (Ct.Po) was higher (p?=?0.016) in participants with IHD at the distal radius. Moreover, trabecular microarchitectural parameters were not significantly different in patients with IHD (p?>?0.05 for all). Adjustment for a priori confounders (age, gender, body mass index, smoking status, alcohol consumption, high blood pressure and diabetes mellitus) did not materially affect the relationship described for Ct.vBMD (p?=?0.002), but differences in Ct.Po were attenuated. Analyses in men alone revealed that only Ct.vBMD was lower at the distal radius in participants with IHD with and without adjustment for a priori confounders (p?=?0.0002 and p?=?0.004, respectively), whereas no statistical differences were found in women, although patterns of differences were similar in both sexes. Moreover, no association was found between IHD and bone parameters at the distal tibia either in men or women.

Conclusions:We have demonstrated that IHD is associated with lower Ct.vBMD of the distal radius.
cortical porosity, cortical volumetric bone mineral density, high-resolution peripheral quantitative computed tomography, ischemic heart disease, vascular calcification
0937-941X
1893-1901
Paccou, J.
1fea7730-cda7-4be3-a73e-a72e8ea09539
Edwards, M.H.
b81ff294-1d16-4a1b-af14-9374c5989d4c
Ward, K.A.
39bd4db1-c948-4e32-930e-7bec8deb54c7
Jameson, K.A.
d5fb142d-06af-456e-9016-17497f94e9f2
Moss, C.L.
ae96895f-5c4a-49cd-a771-53bbd6f1d5fb
Harvey, N.C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Dennison, E.M.
ee647287-edb4-4392-8361-e59fd505b1d1
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Paccou, J.
1fea7730-cda7-4be3-a73e-a72e8ea09539
Edwards, M.H.
b81ff294-1d16-4a1b-af14-9374c5989d4c
Ward, K.A.
39bd4db1-c948-4e32-930e-7bec8deb54c7
Jameson, K.A.
d5fb142d-06af-456e-9016-17497f94e9f2
Moss, C.L.
ae96895f-5c4a-49cd-a771-53bbd6f1d5fb
Harvey, N.C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Dennison, E.M.
ee647287-edb4-4392-8361-e59fd505b1d1
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6

Paccou, J., Edwards, M.H., Ward, K.A., Jameson, K.A., Moss, C.L., Harvey, N.C., Dennison, E.M. and Cooper, C. (2015) Ischemic heart disease is associated with lower cortical volumetric bone mineral density of distal radius. Osteoporosis International, 26 (7), 1893-1901. (doi:10.1007/s00198-015-3132-z). (PMID:25906240)

Record type: Article

Abstract

Summary: In this study, high-resolution peripheral quantitative computed tomography (HR-pQCT) was used to investigate geometric, volumetric and microstructural parameters at the distal radius and at the distal tibia in participants with ischaemic heart disease. We found that, compared with participants without ischaemic heart disease, they had substantially lower cortical volumetric bone mineral density (BMD) at the distal radius.

Introduction:HR-pQCT captures novel aspects of bone geometry and volumetric bone mineral density (vBMD) and offers the ability to measure bone microarchitecture, but data relating measures obtained from this technique in patients with ischemic heart disease (IHD) are lacking.

Methods: Here, we report an analysis from the Hertfordshire Cohort Study, where we were able to study associations between measures obtained from HR-pQCT of distal radius and distal tibia in 350 participants (184 men and 166 women) aged 71.5–80.5 years with or without IHD (e.g. heart attack, angina or heart failure; n?=?75 and n?=?275, respectively).

Results:Analyses for all participants (men and women together) revealed that cortical vBMD (Ct.vBMD) was lower (p?<?0.001) and cortical thickness (Ct.th) was not different (p?=?0.519), whereas cortical porosity (Ct.Po) was higher (p?=?0.016) in participants with IHD at the distal radius. Moreover, trabecular microarchitectural parameters were not significantly different in patients with IHD (p?>?0.05 for all). Adjustment for a priori confounders (age, gender, body mass index, smoking status, alcohol consumption, high blood pressure and diabetes mellitus) did not materially affect the relationship described for Ct.vBMD (p?=?0.002), but differences in Ct.Po were attenuated. Analyses in men alone revealed that only Ct.vBMD was lower at the distal radius in participants with IHD with and without adjustment for a priori confounders (p?=?0.0002 and p?=?0.004, respectively), whereas no statistical differences were found in women, although patterns of differences were similar in both sexes. Moreover, no association was found between IHD and bone parameters at the distal tibia either in men or women.

Conclusions:We have demonstrated that IHD is associated with lower Ct.vBMD of the distal radius.

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More information

Accepted/In Press date: 7 April 2015
e-pub ahead of print date: 24 April 2015
Published date: July 2015
Keywords: cortical porosity, cortical volumetric bone mineral density, high-resolution peripheral quantitative computed tomography, ischemic heart disease, vascular calcification
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 386927
URI: http://eprints.soton.ac.uk/id/eprint/386927
ISSN: 0937-941X
PURE UUID: 71bdd46e-acf7-4e6a-8d8e-ad83cf4821c4
ORCID for K.A. Ward: ORCID iD orcid.org/0000-0001-7034-6750
ORCID for N.C. Harvey: ORCID iD orcid.org/0000-0002-8194-2512
ORCID for E.M. Dennison: ORCID iD orcid.org/0000-0002-3048-4961
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709

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Date deposited: 05 Feb 2016 14:20
Last modified: 18 Feb 2021 17:26

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Contributors

Author: J. Paccou
Author: M.H. Edwards
Author: K.A. Ward ORCID iD
Author: K.A. Jameson
Author: C.L. Moss
Author: N.C. Harvey ORCID iD
Author: E.M. Dennison ORCID iD
Author: C. Cooper ORCID iD

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