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Variability in reference point microindentation and recommendations for testing cortical bone: location, thickness and orientation heterogeneity

Variability in reference point microindentation and recommendations for testing cortical bone: location, thickness and orientation heterogeneity
Variability in reference point microindentation and recommendations for testing cortical bone: location, thickness and orientation heterogeneity
Reference Point Indentation (RPI) has been proposed as a new clinical tool to aid the diagnosis of Osteoporosis. This study has examined the performance of the tool within entire femurs to improve the understanding of the mechanical properties of bone and also to guide future RPI testing to optimize repeatability of results obtained using the technique. Human, bovine, porcine and rat femurs were indented along three longitudinal axes: anterior and posterior: medial and lateral as well as around the circumference of the femoral head and neck. Cortical and subchondral bone thickness was measured using CT and radiography. The study shows that in some samples, bone is too thin to support the high loads applied with the technique and in these cases, RPI values are highly influenced by thickness. The technique will be useful in the mid-shaft region where cortical thickness is greatest, providing previously established guidelines are followed to optimize measurement repeatability, including performing multiple measurements per sample and investigating multiple samples. The study has also provided evidence that RPI values vary significantly with test site, hence mechanical properties should not be inferred from RPI findings alone away from the test site, even within the same bone. In conclusion, RPI appears to be a useful tool for scientific investigation; however further work is required to examine the feasibility of using RPI for assessing differences between healthy and diseased bone in a clinical setting
microindentation, reference point indentation, bone quality, homogeneity, femur
1751-6161
292-304
Coutts, L.V.
90c9e532-5400-4ef8-853f-0e3c311b4f27
Jenkins, T.
e079f477-2bcf-41ea-bb7f-bcbbb5f5c945
Li, T.
20e2eccc-dd4c-4e6c-8261-d54f8f391249
Oreffo, R.O.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Dunlop, D.G.
5f8d8b5c-e516-48b8-831f-c6e5529a52cc
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Harvey, N.C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Thurner, P.J.
ab711ddd-784e-48de-aaad-f56aec40f84f
the OStEO group
Coutts, L.V.
90c9e532-5400-4ef8-853f-0e3c311b4f27
Jenkins, T.
e079f477-2bcf-41ea-bb7f-bcbbb5f5c945
Li, T.
20e2eccc-dd4c-4e6c-8261-d54f8f391249
Oreffo, R.O.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Dunlop, D.G.
5f8d8b5c-e516-48b8-831f-c6e5529a52cc
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Harvey, N.C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Thurner, P.J.
ab711ddd-784e-48de-aaad-f56aec40f84f

Coutts, L.V., Jenkins, T., Li, T., Oreffo, R.O., Dunlop, D.G., Cooper, C., Harvey, N.C. and Thurner, P.J. , the OStEO group (2015) Variability in reference point microindentation and recommendations for testing cortical bone: location, thickness and orientation heterogeneity. Journal of the Mechanical Behavior of Biomedical Materials, 46, 292-304. (doi:10.1016/j.jmbbm.2015.02.004). (PMID:25837158)

Record type: Article

Abstract

Reference Point Indentation (RPI) has been proposed as a new clinical tool to aid the diagnosis of Osteoporosis. This study has examined the performance of the tool within entire femurs to improve the understanding of the mechanical properties of bone and also to guide future RPI testing to optimize repeatability of results obtained using the technique. Human, bovine, porcine and rat femurs were indented along three longitudinal axes: anterior and posterior: medial and lateral as well as around the circumference of the femoral head and neck. Cortical and subchondral bone thickness was measured using CT and radiography. The study shows that in some samples, bone is too thin to support the high loads applied with the technique and in these cases, RPI values are highly influenced by thickness. The technique will be useful in the mid-shaft region where cortical thickness is greatest, providing previously established guidelines are followed to optimize measurement repeatability, including performing multiple measurements per sample and investigating multiple samples. The study has also provided evidence that RPI values vary significantly with test site, hence mechanical properties should not be inferred from RPI findings alone away from the test site, even within the same bone. In conclusion, RPI appears to be a useful tool for scientific investigation; however further work is required to examine the feasibility of using RPI for assessing differences between healthy and diseased bone in a clinical setting

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More information

Accepted/In Press date: 7 February 2015
e-pub ahead of print date: 16 February 2015
Published date: June 2015
Keywords: microindentation, reference point indentation, bone quality, homogeneity, femur
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 386947
URI: http://eprints.soton.ac.uk/id/eprint/386947
ISSN: 1751-6161
PURE UUID: 2ddf6b8a-1609-4f81-9318-37a6c4162f28
ORCID for R.O. Oreffo: ORCID iD orcid.org/0000-0001-5995-6726
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709
ORCID for N.C. Harvey: ORCID iD orcid.org/0000-0002-8194-2512
ORCID for P.J. Thurner: ORCID iD orcid.org/0000-0001-7588-9041

Catalogue record

Date deposited: 05 Feb 2016 15:04
Last modified: 10 Dec 2019 01:53

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