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Systematic analysis of funding awarded for antimicrobial resistance research to institutions in the UK, 1997-2010

Systematic analysis of funding awarded for antimicrobial resistance research to institutions in the UK, 1997-2010
Systematic analysis of funding awarded for antimicrobial resistance research to institutions in the UK, 1997-2010
Objectives: To assess the level of research funding awarded to UK institutions specifically for antimicrobial resistance-related research and how closely the topics funded relate to the clinical and public health burden of resistance.

Methods: Databases and web sites were systematically searched for information on how infectious disease research studies were funded for the period 1997–2010. Studies specifically related to antimicrobial resistance, including bacteriology, virology, mycology and parasitology research, were identified and categorized in terms of funding by pathogen and disease and by a research and development value chain describing the type of science.

Results: The overall dataset included 6165 studies receiving a total investment of £2.6 billion, of which £102 million was directed towards antimicrobial resistance research (5.5% of total studies, 3.9% of total spend). Of 337 resistance-related projects, 175 studies focused on bacteriology (40.2% of total resistance-related spending), 42 focused on antiviral resistance (17.2% of funding) and 51 focused on parasitology (27.4% of funding). Mean annual funding ranged from £1.9 million in 1997 to £22.1 million in 2009.

Conclusions: Despite the fact that the emergence of antimicrobial resistance threatens our future ability to treat many infections, the proportion of the UK infection-research spend targeting this important area is small. There are encouraging signs of increased investment in this area, but it is important that this is sustained and targeted at areas of projected greatest burden. Two areas of particular concern requiring more investment are tuberculosis and multidrug-resistant Gram-negative bacteria.
antibiotics, antifungal, antiviral, antiparasitic
0305-7453
548-554
Head, M.G.
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Fitchett, J.R.
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Cooke, M.K.
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Wurie, F.B.
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Atun, R.
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Hayward, A.C.
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Holmes, A.
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Johnson, A.P.
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Woodford, N.
59246393-e69d-436c-b4ac-a01510d792fb
Head, M.G.
67ce0afc-2fc3-47f4-acf2-8794d27ce69c
Fitchett, J.R.
f8f56bf8-924d-40c0-b0b8-772c885a6c7a
Cooke, M.K.
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Wurie, F.B.
b19a0889-1db7-4e97-adea-2dbca1e0c766
Atun, R.
feb620b0-a662-4642-ba73-2ca4b7dae81a
Hayward, A.C.
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Holmes, A.
e76ecadd-ccc4-425e-9756-14403151764f
Johnson, A.P.
45e67f67-7e1a-4ff2-9563-8ef7aa529810
Woodford, N.
59246393-e69d-436c-b4ac-a01510d792fb

Head, M.G., Fitchett, J.R., Cooke, M.K., Wurie, F.B., Atun, R., Hayward, A.C., Holmes, A., Johnson, A.P. and Woodford, N. (2014) Systematic analysis of funding awarded for antimicrobial resistance research to institutions in the UK, 1997-2010. Journal of Antimicrobial Chemotherapy, 69 (2), 548-554. (doi:10.1093/jac/dkt349). (PMID:24038777)

Record type: Article

Abstract

Objectives: To assess the level of research funding awarded to UK institutions specifically for antimicrobial resistance-related research and how closely the topics funded relate to the clinical and public health burden of resistance.

Methods: Databases and web sites were systematically searched for information on how infectious disease research studies were funded for the period 1997–2010. Studies specifically related to antimicrobial resistance, including bacteriology, virology, mycology and parasitology research, were identified and categorized in terms of funding by pathogen and disease and by a research and development value chain describing the type of science.

Results: The overall dataset included 6165 studies receiving a total investment of £2.6 billion, of which £102 million was directed towards antimicrobial resistance research (5.5% of total studies, 3.9% of total spend). Of 337 resistance-related projects, 175 studies focused on bacteriology (40.2% of total resistance-related spending), 42 focused on antiviral resistance (17.2% of funding) and 51 focused on parasitology (27.4% of funding). Mean annual funding ranged from £1.9 million in 1997 to £22.1 million in 2009.

Conclusions: Despite the fact that the emergence of antimicrobial resistance threatens our future ability to treat many infections, the proportion of the UK infection-research spend targeting this important area is small. There are encouraging signs of increased investment in this area, but it is important that this is sustained and targeted at areas of projected greatest burden. Two areas of particular concern requiring more investment are tuberculosis and multidrug-resistant Gram-negative bacteria.

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Accepted/In Press date: 3 August 2013
e-pub ahead of print date: 13 September 2013
Published date: February 2014
Keywords: antibiotics, antifungal, antiviral, antiparasitic
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 387031
URI: https://eprints.soton.ac.uk/id/eprint/387031
ISSN: 0305-7453
PURE UUID: 4ab7b212-345e-48a8-83c2-1c1fc4877131
ORCID for M.G. Head: ORCID iD orcid.org/0000-0003-1189-0531

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Date deposited: 08 Feb 2016 10:00
Last modified: 06 Jun 2018 12:21

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