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Associations of maternal retinal vasculature with subsequent fetal growth and birth size

Associations of maternal retinal vasculature with subsequent fetal growth and birth size
Associations of maternal retinal vasculature with subsequent fetal growth and birth size
OBJECTIVE:We aimed to study the maternal retinal microvasculature at mid-trimester and its relationship with subsequent fetal growth and birth size.

METHODS:We recruited 732 pregnant women aged 18-46 years in the first trimester with singleton pregnancies. All had retinal photography and fetal scan performed at 26-28 weeks gestation, and subsequent fetal scan at 32-34 weeks gestation. Infant anthropometric measurements were done at birth. Retinal microvasculature was measured using computer software from the retinal photographs.

RESULTS:In multiple linear regression models, each 10 ?m narrowing in maternal retinal arteriolar caliber was associated with decreases of 1.36 mm in fetal head circumference at 32-34 weeks gestation, as well as decreases of 1.50 mm and 2.30 mm in infant head circumference and birth length at delivery, respectively. Each standard deviation decrease in maternal retinal arteriolar fractal dimension was associated with decreases of 1.55 mm in fetal head circumference at 32-34 weeks gestation, as well as decreases of 1.08 mm and 46.42 g in infant head circumference and birth weight at delivery, respectively.

CONCLUSIONS:Narrower retinal arteriolar caliber and a sparser retinal vascular network in mothers, reflecting a suboptimal uteroplacental microvasculature during mid-pregnancy, were associated with poorer fetal growth and birth size.
1932-6203
1-14
Li, L.J.
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Aris, I.
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Su, L.L.
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Tint, M.T.
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Cheung, C.Y.
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Irkram, M.K.
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Gluckman, P.
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Godfrey, K.M.
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Tan, K.H.
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Yeo, G.
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Yap, F.
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Kwek, K.
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Saw, S.M.
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Chong, Y.S.
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Wong, T.Y.
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Lee, Y.S.
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Li, L.J.
1b806dc9-1796-4626-ad83-d70e7efea9a9
Aris, I.
d6f3d051-1789-4723-9e24-907514670b7a
Su, L.L.
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Tint, M.T.
02d6a006-3b94-4328-b3c3-147a618d66c3
Cheung, C.Y.
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Irkram, M.K.
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Gluckman, P.
dadc86d4-4eaa-4589-b560-413a9e564558
Godfrey, K.M.
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Tan, K.H.
d1d689a8-cf28-4669-8493-b3f8fc704882
Yeo, G.
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Yap, F.
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Kwek, K.
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Saw, S.M.
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Chong, Y.S.
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Wong, T.Y.
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Lee, Y.S.
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Li, L.J., Aris, I., Su, L.L., Tint, M.T., Cheung, C.Y., Irkram, M.K., Gluckman, P., Godfrey, K.M., Tan, K.H., Yeo, G., Yap, F., Kwek, K., Saw, S.M., Chong, Y.S., Wong, T.Y. and Lee, Y.S. (2015) Associations of maternal retinal vasculature with subsequent fetal growth and birth size. PLoS ONE, 10 (4), 1-14. (doi:10.1371/journal.pone.0118250.). (PMID:25909909)

Record type: Article

Abstract

OBJECTIVE:We aimed to study the maternal retinal microvasculature at mid-trimester and its relationship with subsequent fetal growth and birth size.

METHODS:We recruited 732 pregnant women aged 18-46 years in the first trimester with singleton pregnancies. All had retinal photography and fetal scan performed at 26-28 weeks gestation, and subsequent fetal scan at 32-34 weeks gestation. Infant anthropometric measurements were done at birth. Retinal microvasculature was measured using computer software from the retinal photographs.

RESULTS:In multiple linear regression models, each 10 ?m narrowing in maternal retinal arteriolar caliber was associated with decreases of 1.36 mm in fetal head circumference at 32-34 weeks gestation, as well as decreases of 1.50 mm and 2.30 mm in infant head circumference and birth length at delivery, respectively. Each standard deviation decrease in maternal retinal arteriolar fractal dimension was associated with decreases of 1.55 mm in fetal head circumference at 32-34 weeks gestation, as well as decreases of 1.08 mm and 46.42 g in infant head circumference and birth weight at delivery, respectively.

CONCLUSIONS:Narrower retinal arteriolar caliber and a sparser retinal vascular network in mothers, reflecting a suboptimal uteroplacental microvasculature during mid-pregnancy, were associated with poorer fetal growth and birth size.

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Accepted/In Press date: 18 December 2014
Published date: 24 April 2015
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 387050
URI: http://eprints.soton.ac.uk/id/eprint/387050
ISSN: 1932-6203
PURE UUID: 514aec96-d425-4741-bf58-3298fe72629e
ORCID for K.M. Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

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Date deposited: 08 Feb 2016 11:37
Last modified: 07 Oct 2020 01:35

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Contributors

Author: L.J. Li
Author: I. Aris
Author: L.L. Su
Author: M.T. Tint
Author: C.Y. Cheung
Author: M.K. Irkram
Author: P. Gluckman
Author: K.M. Godfrey ORCID iD
Author: K.H. Tan
Author: G. Yeo
Author: F. Yap
Author: K. Kwek
Author: S.M. Saw
Author: Y.S. Chong
Author: T.Y. Wong
Author: Y.S. Lee

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