The University of Southampton
University of Southampton Institutional Repository

Ethnic differences in effects of maternal pre-pregnancy and pregnancy adiposity on offspring size and adiposity

Ethnic differences in effects of maternal pre-pregnancy and pregnancy adiposity on offspring size and adiposity
Ethnic differences in effects of maternal pre-pregnancy and pregnancy adiposity on offspring size and adiposity
CONTEXT: Maternal adiposity and overnutrition, both before and during pregnancy, plays a key role in the subsequent development of obesity and metabolic outcomes in offspring.

OBJECTIVE:We explored the hypothesis that maternal adiposity (pre-pregnancy and at 26-28 weeks' gestation) and mid-pregnancy gestational weight gain (GWG) are independently associated with offspring size and adiposity in early childhood, and determined whether these effects are ethnicity dependent.

DESIGN:In a prospective mother-offspring cohort study (N = 976, 56% Chinese, 26% Malay, and 18% Indian), we assessed the associations of offspring size (weight, length) and adiposity (subscapular and triceps skinfolds), measured at birth and age 6, 12, 18, and 24 mo, with maternal pre-pregnancy body mass index (ppBMI), mid-pregnancy GWG, and mid-pregnancy four-site skinfold thicknesses (triceps, biceps, subscapular, suprailiac).

RESULTS: ppBMI and mid-pregnancy GWG were independently associated with postnatal weight up to 2 y and skinfold thickness at birth. Weight and subscapular and triceps skinfolds at birth increased by 2.56% (95% confidence interval, 1.68-3.45%), 3.85% (2.16-5.57%), and 2.14% (0.54-3.75%), respectively for every SD increase in ppBMI. Similarly, a one-SD increase in GWG increased weight and subscapular and triceps skinfolds at birth by 2.44% (1.66-3.23%), 3.28% (1.75-4.84%), and 3.23% (1.65-4.84%), respectively. ppBMI and mid-pregnancy suprailiac skinfold independently predicted postnatal skinfold adiposity up to 2 years of age, whereas only GWG predicted postnatal length. The associations of GWG with postnatal weight and length were present only among Chinese and Indians, but not Malays (P < .05 for interaction).

CONCLUSIONS: ppBMI and GWG are independent modifiable factors for child size and adiposity up to 2 years of age. The associations are ethnic-dependent, and underscore the importance of ethnic specific studies before generalizing the applicability of risk factors reported in other populations
0021-972X
3641-3650
Lin, X.
723753d7-5afe-4a4b-8f53-28bff7912c16
Aris, I.M.
ee15a46e-ead3-4b4a-a208-d39038a85480
Tint, M.T.
02d6a006-3b94-4328-b3c3-147a618d66c3
Soh, S.E.
00a5ad13-4c5b-4fad-aaa9-d080d9aa63e8
Godfrey, K.M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Yeo, G.S.
11c108f8-5a8e-4e4f-a818-3c1a443aec7c
Kwek, K.
1a9b6c6e-a5e9-40a2-9bfe-44c2cea62a98
Chan, J.K.
9d7dc149-6fec-483b-b596-4b1f7081ce3e
Gluckman, P.D.
492295c0-ef71-4871-ad5a-771c98e1059a
Chong, Y.S.
b50c99c9-4d83-46c5-a1c7-23f9a553ab8a
Yap, F.
2c155211-be02-4dd5-9528-16a714e77452
Holbrook, J.D.
070ac5b7-0f42-4425-994a-8135218212d7
Lee, Y.S.
829a41bb-945c-49cd-ad12-0f3d9c2782c6
Lin, X.
723753d7-5afe-4a4b-8f53-28bff7912c16
Aris, I.M.
ee15a46e-ead3-4b4a-a208-d39038a85480
Tint, M.T.
02d6a006-3b94-4328-b3c3-147a618d66c3
Soh, S.E.
00a5ad13-4c5b-4fad-aaa9-d080d9aa63e8
Godfrey, K.M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Yeo, G.S.
11c108f8-5a8e-4e4f-a818-3c1a443aec7c
Kwek, K.
1a9b6c6e-a5e9-40a2-9bfe-44c2cea62a98
Chan, J.K.
9d7dc149-6fec-483b-b596-4b1f7081ce3e
Gluckman, P.D.
492295c0-ef71-4871-ad5a-771c98e1059a
Chong, Y.S.
b50c99c9-4d83-46c5-a1c7-23f9a553ab8a
Yap, F.
2c155211-be02-4dd5-9528-16a714e77452
Holbrook, J.D.
070ac5b7-0f42-4425-994a-8135218212d7
Lee, Y.S.
829a41bb-945c-49cd-ad12-0f3d9c2782c6

Lin, X., Aris, I.M., Tint, M.T., Soh, S.E., Godfrey, K.M., Yeo, G.S., Kwek, K., Chan, J.K., Gluckman, P.D., Chong, Y.S., Yap, F., Holbrook, J.D. and Lee, Y.S. (2015) Ethnic differences in effects of maternal pre-pregnancy and pregnancy adiposity on offspring size and adiposity. Journal of Clinical Endocrinology & Metabolism, 100 (10), 3641-3650. (doi:10.1210/jc.2015-1728). (PMID:26200236)

Record type: Article

Abstract

CONTEXT: Maternal adiposity and overnutrition, both before and during pregnancy, plays a key role in the subsequent development of obesity and metabolic outcomes in offspring.

OBJECTIVE:We explored the hypothesis that maternal adiposity (pre-pregnancy and at 26-28 weeks' gestation) and mid-pregnancy gestational weight gain (GWG) are independently associated with offspring size and adiposity in early childhood, and determined whether these effects are ethnicity dependent.

DESIGN:In a prospective mother-offspring cohort study (N = 976, 56% Chinese, 26% Malay, and 18% Indian), we assessed the associations of offspring size (weight, length) and adiposity (subscapular and triceps skinfolds), measured at birth and age 6, 12, 18, and 24 mo, with maternal pre-pregnancy body mass index (ppBMI), mid-pregnancy GWG, and mid-pregnancy four-site skinfold thicknesses (triceps, biceps, subscapular, suprailiac).

RESULTS: ppBMI and mid-pregnancy GWG were independently associated with postnatal weight up to 2 y and skinfold thickness at birth. Weight and subscapular and triceps skinfolds at birth increased by 2.56% (95% confidence interval, 1.68-3.45%), 3.85% (2.16-5.57%), and 2.14% (0.54-3.75%), respectively for every SD increase in ppBMI. Similarly, a one-SD increase in GWG increased weight and subscapular and triceps skinfolds at birth by 2.44% (1.66-3.23%), 3.28% (1.75-4.84%), and 3.23% (1.65-4.84%), respectively. ppBMI and mid-pregnancy suprailiac skinfold independently predicted postnatal skinfold adiposity up to 2 years of age, whereas only GWG predicted postnatal length. The associations of GWG with postnatal weight and length were present only among Chinese and Indians, but not Malays (P < .05 for interaction).

CONCLUSIONS: ppBMI and GWG are independent modifiable factors for child size and adiposity up to 2 years of age. The associations are ethnic-dependent, and underscore the importance of ethnic specific studies before generalizing the applicability of risk factors reported in other populations

Full text not available from this repository.

More information

Accepted/In Press date: 16 July 2015
e-pub ahead of print date: 21 July 2015
Published date: October 2015
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 387055
URI: http://eprints.soton.ac.uk/id/eprint/387055
ISSN: 0021-972X
PURE UUID: 7cc67237-e290-4364-bf75-d35e0d6ad8a5
ORCID for K.M. Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

Catalogue record

Date deposited: 08 Feb 2016 14:39
Last modified: 07 Oct 2020 01:35

Export record

Altmetrics

Contributors

Author: X. Lin
Author: I.M. Aris
Author: M.T. Tint
Author: S.E. Soh
Author: K.M. Godfrey ORCID iD
Author: G.S. Yeo
Author: K. Kwek
Author: J.K. Chan
Author: P.D. Gluckman
Author: Y.S. Chong
Author: F. Yap
Author: J.D. Holbrook
Author: Y.S. Lee

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×