CD57 in human natural killer cells and T-lymphocytes
CD57 in human natural killer cells and T-lymphocytes
The CD57 antigen (alternatively HNK-1, LEU-7, or L2) is routinely used to identify terminally differentiated ‘senescent’ cells with reduced proliferative capacity and altered functional properties. In this article, we review current understanding of the attributes of CD57-expressing T-cells and NK cells in both health and disease and discuss how this marker can inform researchers about their likely functions in human blood and tissues in vivo. While CD57 expression on human lymphocytes indicates an inability to proliferate, these cells also display high cytotoxic potential, and CD57pos NK cells exhibit both memory-like features and potent effector functions. Accordingly, frequencies of CD57-expressing cells in blood and tissues have been correlated with clinical prognosis in chronic infections or various cancers and with human aging. Functional modulation of senescent CD57pos T-cells and mature CD57pos NK cells may therefore represent innovative strategies for protection against human immunological aging and/or various chronic diseases.
cd57, klrg1, nkg2c, memory nk cells, senescence, nk maturation
1-12
Kared, Hassen
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Martelli, Serena
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Ng, Tze Pin
a1b422b2-81bf-4fbf-a674-e3deae6585b6
Pender, Sylvia LF
62528b03-ec42-41bb-80fe-48454c2c5242
Larbi, Anis
563f760e-b258-419a-aaa0-d291c8b77ce5
5 February 2016
Kared, Hassen
f8fded21-31be-4eb6-b41d-9f47d9879bb4
Martelli, Serena
3a6d7c3d-1972-4b5b-ada0-45f0247a763f
Ng, Tze Pin
a1b422b2-81bf-4fbf-a674-e3deae6585b6
Pender, Sylvia LF
62528b03-ec42-41bb-80fe-48454c2c5242
Larbi, Anis
563f760e-b258-419a-aaa0-d291c8b77ce5
Kared, Hassen, Martelli, Serena, Ng, Tze Pin, Pender, Sylvia LF and Larbi, Anis
(2016)
CD57 in human natural killer cells and T-lymphocytes.
Cancer Immunology Immunotherapy, .
(doi:10.1007/s00262-016-1803-z).
(PMID:26850637)
Abstract
The CD57 antigen (alternatively HNK-1, LEU-7, or L2) is routinely used to identify terminally differentiated ‘senescent’ cells with reduced proliferative capacity and altered functional properties. In this article, we review current understanding of the attributes of CD57-expressing T-cells and NK cells in both health and disease and discuss how this marker can inform researchers about their likely functions in human blood and tissues in vivo. While CD57 expression on human lymphocytes indicates an inability to proliferate, these cells also display high cytotoxic potential, and CD57pos NK cells exhibit both memory-like features and potent effector functions. Accordingly, frequencies of CD57-expressing cells in blood and tissues have been correlated with clinical prognosis in chronic infections or various cancers and with human aging. Functional modulation of senescent CD57pos T-cells and mature CD57pos NK cells may therefore represent innovative strategies for protection against human immunological aging and/or various chronic diseases.
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More information
Accepted/In Press date: 29 January 2016
Published date: 5 February 2016
Keywords:
cd57, klrg1, nkg2c, memory nk cells, senescence, nk maturation
Organisations:
Clinical & Experimental Sciences
Identifiers
Local EPrints ID: 387098
URI: http://eprints.soton.ac.uk/id/eprint/387098
ISSN: 0340-7004
PURE UUID: 8e4fa06f-9722-4f28-9055-3e6aca66ff34
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Date deposited: 09 Feb 2016 12:31
Last modified: 15 Mar 2024 03:08
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Contributors
Author:
Hassen Kared
Author:
Serena Martelli
Author:
Tze Pin Ng
Author:
Anis Larbi
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