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Increase in fracture risk following unintentional weight loss in postmenopausal women: The Global Longitudinal Study of Osteoporosis in Women

Increase in fracture risk following unintentional weight loss in postmenopausal women: The Global Longitudinal Study of Osteoporosis in Women
Increase in fracture risk following unintentional weight loss in postmenopausal women: The Global Longitudinal Study of Osteoporosis in Women
Increased fracture risk has been associated with weight loss in postmenopausal women but the time course over which this occurs has not been established. The aim of this study was to examine the effects of unintentional weight loss of ?10 lb (4.5?kg) in postmenopausal women on fracture risk at multiple sites up to 5 years following weight loss. Using data from the Global Longitudinal Study of Osteoporosis in Women (GLOW) we analyzed the relationships between self-reported unintentional weight loss of ?10 lb at baseline, year 2, or year 3 and incident clinical fracture in the years following weight loss. Complete data were available in 40,179 women (mean age?±?SD 68?±?8.3 years). Five-year cumulative fracture rate was estimated using the Kaplan-Meier method, and adjusted hazard ratios for weight loss as a time-varying covariate were calculated from Cox multiple regression models. Unintentional weight loss at baseline was associated with a significantly increased risk of fracture of the clavicle, wrist, spine, rib, hip, and pelvis for up to 5 years following weight loss. Adjusted hazard ratios showed a significant association between unintentional weight loss and fracture of the hip, spine, and clavicle within 1 year of weight loss, and these associations were still present at 5 years. These findings demonstrate increased fracture risk at several sites after unintentional weight loss in postmenopausal women. This increase is seen as early as 1 year following weight loss, emphasizing the need for prompt fracture risk assessment and appropriate management to reduce fracture risk in this population.
weight loss, fracture, postmenopausal women
0884-0431
1-14
Compston, J.E.
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Wyman, A.
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Fitzgerald, G.
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Adachi, J.D.
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Chapurlat, R.C.
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Cooper, C.
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Diez-Perez, A.
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Gehlbach, S.H.
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Greenspan, S.L.
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Hooven, F.H.
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LaCroix, A.Z.
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March, L.
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Netelenbos, J.C.
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Nieves, J.W.
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Pfeilschifter, J.
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Rossini, M.
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Roux, C.
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Saag, K.G.
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Siris, E.S.
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Silverman, S.
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Watts, N.B.
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Anderson, F.A.
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Compston, J.E.
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Wyman, A.
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Fitzgerald, G.
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Adachi, J.D.
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Chapurlat, R.C.
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Cooper, C.
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Diez-Perez, A.
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Gehlbach, S.H.
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Greenspan, S.L.
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Hooven, F.H.
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LaCroix, A.Z.
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March, L.
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Netelenbos, J.C.
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Nieves, J.W.
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Pfeilschifter, J.
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Rossini, M.
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Roux, C.
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Saag, K.G.
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Siris, E.S.
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Silverman, S.
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Watts, N.B.
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Anderson, F.A.
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Compston, J.E., Wyman, A., Fitzgerald, G., Adachi, J.D., Chapurlat, R.C., Cooper, C., Diez-Perez, A., Gehlbach, S.H., Greenspan, S.L., Hooven, F.H., LaCroix, A.Z., March, L., Netelenbos, J.C., Nieves, J.W., Pfeilschifter, J., Rossini, M., Roux, C., Saag, K.G., Siris, E.S., Silverman, S., Watts, N.B. and Anderson, F.A. (2016) Increase in fracture risk following unintentional weight loss in postmenopausal women: The Global Longitudinal Study of Osteoporosis in Women. Journal of Bone and Mineral Research, 1-14. (doi:10.1002/jbmr.2810). (PMID:26861139)

Record type: Article

Abstract

Increased fracture risk has been associated with weight loss in postmenopausal women but the time course over which this occurs has not been established. The aim of this study was to examine the effects of unintentional weight loss of ?10 lb (4.5?kg) in postmenopausal women on fracture risk at multiple sites up to 5 years following weight loss. Using data from the Global Longitudinal Study of Osteoporosis in Women (GLOW) we analyzed the relationships between self-reported unintentional weight loss of ?10 lb at baseline, year 2, or year 3 and incident clinical fracture in the years following weight loss. Complete data were available in 40,179 women (mean age?±?SD 68?±?8.3 years). Five-year cumulative fracture rate was estimated using the Kaplan-Meier method, and adjusted hazard ratios for weight loss as a time-varying covariate were calculated from Cox multiple regression models. Unintentional weight loss at baseline was associated with a significantly increased risk of fracture of the clavicle, wrist, spine, rib, hip, and pelvis for up to 5 years following weight loss. Adjusted hazard ratios showed a significant association between unintentional weight loss and fracture of the hip, spine, and clavicle within 1 year of weight loss, and these associations were still present at 5 years. These findings demonstrate increased fracture risk at several sites after unintentional weight loss in postmenopausal women. This increase is seen as early as 1 year following weight loss, emphasizing the need for prompt fracture risk assessment and appropriate management to reduce fracture risk in this population.

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Accepted/In Press date: 5 February 2016
e-pub ahead of print date: 9 February 2016
Keywords: weight loss, fracture, postmenopausal women
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 387271
URI: http://eprints.soton.ac.uk/id/eprint/387271
ISSN: 0884-0431
PURE UUID: c32eeb42-4ad6-402f-95ac-9bfa50930b26
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709

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Date deposited: 15 Feb 2016 10:34
Last modified: 17 Dec 2019 01:57

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Contributors

Author: J.E. Compston
Author: A. Wyman
Author: G. Fitzgerald
Author: J.D. Adachi
Author: R.C. Chapurlat
Author: C. Cooper ORCID iD
Author: A. Diez-Perez
Author: S.H. Gehlbach
Author: S.L. Greenspan
Author: F.H. Hooven
Author: A.Z. LaCroix
Author: L. March
Author: J.C. Netelenbos
Author: J.W. Nieves
Author: J. Pfeilschifter
Author: M. Rossini
Author: C. Roux
Author: K.G. Saag
Author: E.S. Siris
Author: S. Silverman
Author: N.B. Watts
Author: F.A. Anderson

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