The University of Southampton
University of Southampton Institutional Repository

Letter. Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

Letter. Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis
Letter. Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis
Genetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common, complex skin disease, we performed a meta-analysis of >15 million genetic variants in 21,399 cases and 95,464 controls from populations of European, African, Japanese and Latino ancestry, followed by replication in 32,059 cases and 228,628 controls from 18 studies. We identified ten new risk loci, bringing the total number of known atopic dermatitis risk loci to 31 (with new secondary signals at four of these loci). Notably, the new loci include candidate genes with roles in the regulation of innate host defenses and T cell function, underscoring the important contribution of (auto)immune mechanisms to atopic dermatitis pathogenesis.
1061-4036
1449-1456
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Paternoster, Lavinia, Standl, Marie, Waage, Johannes, Baurecht, Hansjörg, Hotze, Melanie, Strachan, David P., Curtin, John A., Bønnelykke, Klaus, Tian, Chao, Takahashi, Atsushi, Esparza-Gordillo, Jorge, Alves, Alexessander Couto, Thyssen, Jacob P., den Dekker, Herman T., Ferreira, Manuel A., Altmaier, Elisabeth, Sleiman, Patrick M.A., Xiao, Feng Li, Gonzalez, Juan R, Marenholz, Ingo, Kalb, Birgit, Pino-Yanes, Maria, Xu, Cheng-Jian, Carstensen, Lisbeth, Groen-Blokhuis, Maria M., Venturini, Cristina, Pennell, Craig E., Barton, Sheila J., Levin, Albert M., Curjuric, Ivan, Bustamante, Mariona, Kreiner-Møller, Eskil, Lockett, Gabrielle A., Bacelis, Jonas, Bunyavanich, Supinda, Myers, Rachel A., Matanovic, Anja, Kumar, Ashish, Tung, Joyce Y., Hirota, Tomomitsu, Kubo, Michiaki, McArdle, Wendy L, Henderson, A John, Kemp, John P., Zheng, Jie, Smith, George Davey, Rüschendorf, Franz, Bauerfeind, Anja, Lee-Kirsch, Min Ae, Arnold, Andreas, Homuth, Georg, Schmidt, Carsten O., Mangold, Elisabeth, Cichon, Sven, Keil, Thomas, Rodríguez, Elke, Peters, Annette, Franke, Andre, Lieb, Wolfgang, Novak, Natalija, Fölster-Holst, Regina, Horikoshi, Momoko, Pekkanen, Juha, Sebert, Sylvain, Husemoen, Lise L., Grarup, Niels, de Jongste, Johan C., Rivadeneira, Fernando, Hofman, Albert, Jaddoe, Vincent W.V., Pasmans, Suzanne G.M.A., Elbert, Niels J, Uitterlinden, André G., Marks, Guy B., Thompson, Philip J., Matheson, Melanie C., Robertson, Colin F., Ried, Janina S., Li, Jin, Zuo, Xian Bo, Zheng, Xiao Dong, Yin, Xian Yong, Sun, Liang Dan, McAleer, Maeve A., O'Regan, Grainne M., Fahy, Caoimhe M.R., Campbell, Linda E., Macek, Milan, Kurek, Michael, Hu, Donglei, Eng, Celeste, Postma, Dirkje S., Feenstra, Bjarke, Geller, Frank, Hottenga, Jouke Jan, Middeldorp, Christel M., Hysi, Pirro, Bataille, Veronique, Spector, Tim, Tiesler, Carla M.T., Thiering, Elisabeth, Pahukasahasram, Badri, Yang, James J., Imboden, Medea, Huntsman, Scott, Vilor-Tejedor, Natàlia, Relton, Caroline L., Myhre, Ronny, Nystad, Wenche, Custovic, Adnan, Weiss, Scott T., Meyers, Deborah A., Söderhäll, Cilla, Melén, Erik, Ober, Carole, Raby, Benjamin A., Simpson, Angela, Jacobsson, Bo, Holloway, John W., Bisgaard, Hans, Sunyer, Jordi, Probst-Hensch, Nicole M., Williams, L. Keoki, Godfrey, Keith M., Wang, Carol A., Boomsma, Dorret I., Melbye, Mads, Koppelman, Gerard H., Jarvis, Deborah, McLean, W H Irwin, Irvine, Alan D., Zhang, Xue Jun, Hakonarson, Hakon, Gieger, Christian, Burchard, Esteban G., Martin, Nicholas G., Duijts, Liesbeth, Linneberg, Allan, Jarvelin, Marjo-Riitta, Nöthen, Markus M., Lau, Susanne, Hübner, Norbert, Lee, Young-Ae, Tamari, Mayumi, Hinds, David A., Glass, Daniel, Brown, Sara J., Heinrich, Joachim, Evans, David M. and Weidinger, Stephan (2015) Letter. Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis. Nature Genetics, 47 (12), 1449-1456. (doi:10.1038/ng.3424). (PMID:26482879)

Record type: Article

Abstract

Genetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common, complex skin disease, we performed a meta-analysis of >15 million genetic variants in 21,399 cases and 95,464 controls from populations of European, African, Japanese and Latino ancestry, followed by replication in 32,059 cases and 228,628 controls from 18 studies. We identified ten new risk loci, bringing the total number of known atopic dermatitis risk loci to 31 (with new secondary signals at four of these loci). Notably, the new loci include candidate genes with roles in the regulation of innate host defenses and T cell function, underscoring the important contribution of (auto)immune mechanisms to atopic dermatitis pathogenesis.

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NG-LE40675R1_Paternoster_200815.pdf - Accepted Manuscript
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Accepted/In Press date: 25 September 2015
e-pub ahead of print date: 19 October 2015
Published date: December 2015
Organisations: Human Development & Health, Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 387988
URI: https://eprints.soton.ac.uk/id/eprint/387988
ISSN: 1061-4036
PURE UUID: e5ec5db4-68ef-4c62-884d-05cf531f81fd
ORCID for Sheila J. Barton: ORCID iD orcid.org/0000-0003-4963-4242
ORCID for John W. Holloway: ORCID iD orcid.org/0000-0001-9998-0464
ORCID for Keith M. Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

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Date deposited: 17 Feb 2016 15:17
Last modified: 17 Jul 2019 01:17

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Contributors

Author: Lavinia Paternoster
Author: Marie Standl
Author: Johannes Waage
Author: Hansjörg Baurecht
Author: Melanie Hotze
Author: David P. Strachan
Author: John A. Curtin
Author: Klaus Bønnelykke
Author: Chao Tian
Author: Atsushi Takahashi
Author: Jorge Esparza-Gordillo
Author: Alexessander Couto Alves
Author: Jacob P. Thyssen
Author: Herman T. den Dekker
Author: Manuel A. Ferreira
Author: Elisabeth Altmaier
Author: Patrick M.A. Sleiman
Author: Feng Li Xiao
Author: Juan R Gonzalez
Author: Ingo Marenholz
Author: Birgit Kalb
Author: Maria Pino-Yanes
Author: Cheng-Jian Xu
Author: Lisbeth Carstensen
Author: Maria M. Groen-Blokhuis
Author: Cristina Venturini
Author: Craig E. Pennell
Author: Albert M. Levin
Author: Ivan Curjuric
Author: Mariona Bustamante
Author: Eskil Kreiner-Møller
Author: Gabrielle A. Lockett
Author: Jonas Bacelis
Author: Supinda Bunyavanich
Author: Rachel A. Myers
Author: Anja Matanovic
Author: Ashish Kumar
Author: Joyce Y. Tung
Author: Tomomitsu Hirota
Author: Michiaki Kubo
Author: Wendy L McArdle
Author: A John Henderson
Author: John P. Kemp
Author: Jie Zheng
Author: George Davey Smith
Author: Franz Rüschendorf
Author: Anja Bauerfeind
Author: Min Ae Lee-Kirsch
Author: Andreas Arnold
Author: Georg Homuth
Author: Carsten O. Schmidt
Author: Elisabeth Mangold
Author: Sven Cichon
Author: Thomas Keil
Author: Elke Rodríguez
Author: Annette Peters
Author: Andre Franke
Author: Wolfgang Lieb
Author: Natalija Novak
Author: Regina Fölster-Holst
Author: Momoko Horikoshi
Author: Juha Pekkanen
Author: Sylvain Sebert
Author: Lise L. Husemoen
Author: Niels Grarup
Author: Johan C. de Jongste
Author: Fernando Rivadeneira
Author: Albert Hofman
Author: Vincent W.V. Jaddoe
Author: Suzanne G.M.A. Pasmans
Author: Niels J Elbert
Author: André G. Uitterlinden
Author: Guy B. Marks
Author: Philip J. Thompson
Author: Melanie C. Matheson
Author: Colin F. Robertson
Author: Janina S. Ried
Author: Jin Li
Author: Xian Bo Zuo
Author: Xiao Dong Zheng
Author: Xian Yong Yin
Author: Liang Dan Sun
Author: Maeve A. McAleer
Author: Grainne M. O'Regan
Author: Caoimhe M.R. Fahy
Author: Linda E. Campbell
Author: Milan Macek
Author: Michael Kurek
Author: Donglei Hu
Author: Celeste Eng
Author: Dirkje S. Postma
Author: Bjarke Feenstra
Author: Frank Geller
Author: Jouke Jan Hottenga
Author: Christel M. Middeldorp
Author: Pirro Hysi
Author: Veronique Bataille
Author: Tim Spector
Author: Carla M.T. Tiesler
Author: Elisabeth Thiering
Author: Badri Pahukasahasram
Author: James J. Yang
Author: Medea Imboden
Author: Scott Huntsman
Author: Natàlia Vilor-Tejedor
Author: Caroline L. Relton
Author: Ronny Myhre
Author: Wenche Nystad
Author: Adnan Custovic
Author: Scott T. Weiss
Author: Deborah A. Meyers
Author: Cilla Söderhäll
Author: Erik Melén
Author: Carole Ober
Author: Benjamin A. Raby
Author: Angela Simpson
Author: Bo Jacobsson
Author: Hans Bisgaard
Author: Jordi Sunyer
Author: Nicole M. Probst-Hensch
Author: L. Keoki Williams
Author: Carol A. Wang
Author: Dorret I. Boomsma
Author: Mads Melbye
Author: Gerard H. Koppelman
Author: Deborah Jarvis
Author: W H Irwin McLean
Author: Alan D. Irvine
Author: Xue Jun Zhang
Author: Hakon Hakonarson
Author: Christian Gieger
Author: Esteban G. Burchard
Author: Nicholas G. Martin
Author: Liesbeth Duijts
Author: Allan Linneberg
Author: Marjo-Riitta Jarvelin
Author: Markus M. Nöthen
Author: Susanne Lau
Author: Norbert Hübner
Author: Young-Ae Lee
Author: Mayumi Tamari
Author: David A. Hinds
Author: Daniel Glass
Author: Sara J. Brown
Author: Joachim Heinrich
Author: David M. Evans
Author: Stephan Weidinger

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