Change of cochlear micromechanics due to different types of hearing loss
Change of cochlear micromechanics due to different types of hearing loss
The reasons for hearing loss are complex and currently the mechanics are not entirely clear. Outer hair cell (OHC) loss is believed to play an important role. Experimental observations shown that damage on OHCs due to ototoxic acid starts from the outermost row to the innermost row, whereas, loss of OHCs due to intense noise exposure occurs from the innermost row to the outermost row. Inspired by these experiments, this study employs the finite element method to develop a detailed model of a slice of the human cochlea including cochlear fine structures. OHC motility is implemented by applying forces at the two ends of the OHCs in response to stereocilia deflection, which are believed to be a key process in cochlear amplification. In this way, the effects of a loss of OHCs due to either intense noise exposure or ototoxic acid can be studied by suppressing forces on individual OHCs. Change of cochlear mechanical amplification and vibration patterns inside the organ of Corti due to different hearing loss mechanisms can thus be predicted
1-4
Ni, Guangjian
f6ddc112-7d81-403a-b97a-7ecbc8fd4e59
Elliott, Stephen
721dc55c-8c3e-4895-b9c4-82f62abd3567
November 2015
Ni, Guangjian
f6ddc112-7d81-403a-b97a-7ecbc8fd4e59
Elliott, Stephen
721dc55c-8c3e-4895-b9c4-82f62abd3567
Ni, Guangjian and Elliott, Stephen
(2015)
Change of cochlear micromechanics due to different types of hearing loss.
Bioinformatics and Bioengineering (BIBE), 2015 IEEE 15th International Conference on,, Belgrade, Serbia.
02 - 04 Nov 2015.
.
(doi:10.1109/BIBE.2015.7367683).
Record type:
Conference or Workshop Item
(Paper)
Abstract
The reasons for hearing loss are complex and currently the mechanics are not entirely clear. Outer hair cell (OHC) loss is believed to play an important role. Experimental observations shown that damage on OHCs due to ototoxic acid starts from the outermost row to the innermost row, whereas, loss of OHCs due to intense noise exposure occurs from the innermost row to the outermost row. Inspired by these experiments, this study employs the finite element method to develop a detailed model of a slice of the human cochlea including cochlear fine structures. OHC motility is implemented by applying forces at the two ends of the OHCs in response to stereocilia deflection, which are believed to be a key process in cochlear amplification. In this way, the effects of a loss of OHCs due to either intense noise exposure or ototoxic acid can be studied by suppressing forces on individual OHCs. Change of cochlear mechanical amplification and vibration patterns inside the organ of Corti due to different hearing loss mechanisms can thus be predicted
Text
07367683.pdf
- Accepted Manuscript
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Published date: November 2015
Venue - Dates:
Bioinformatics and Bioengineering (BIBE), 2015 IEEE 15th International Conference on,, Belgrade, Serbia, 2015-11-02 - 2015-11-04
Organisations:
Signal Processing & Control Grp
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Local EPrints ID: 388036
URI: http://eprints.soton.ac.uk/id/eprint/388036
PURE UUID: 7965a684-3383-4ee0-b0f3-c31970b42cec
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Date deposited: 19 Feb 2016 12:49
Last modified: 14 Mar 2024 22:50
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Author:
Guangjian Ni
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