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Nonalcoholic fatty liver disease is associated with higher 1-year all-cause rehospitalization rates in patients admitted for acute heart failure.

Nonalcoholic fatty liver disease is associated with higher 1-year all-cause rehospitalization rates in patients admitted for acute heart failure.
Nonalcoholic fatty liver disease is associated with higher 1-year all-cause rehospitalization rates in patients admitted for acute heart failure.
Repeat hospitalization due to acute heart failure (HF) is a global public health problem that markedly impacts on health resource use. Identifying novel predictors of rehospitalization would help physicians to determine the optimal postdischarge plan for preventing HF rehospitalization. Nonalcoholic fatty liver disease (NAFLD) is an emerging risk factor for many heart diseases, including HF. We assessed whether NAFLD at hospital admission predicts 1-year all-cause rehospitalization in patients with acute HF.We enrolled all patients consecutively admitted for acute HF to our General Medicine Division, from January 2013 to April 2014, after excluding patients with acute myocardial infarction, severe heart valve diseases, malignancy, known liver diseases, and those with volume overload related to extracardiac causes. NAFLD was diagnosed by ultrasonography and exclusion of competing etiologies. The primary outcome of the study was the 1-year all-cause rehospitalization rate.Among the 107 patients enrolled in the study, the cumulative rehospitalization rate was 12.1% at 1 month, 25.2% at 3 months, 29.9% at 6 months, and 38.3% at 1 year. Patients with NAFLD had markedly higher 1-year rehospitalization rates than those without NAFLD (58% vs 21% at 1 y; P?<?0.001 by the log-rank test). Cox regression analysis revealed that NAFLD was associated with a 5.5-fold increased risk of rehospitalization (adjusted hazard ratio 5.56, 95% confidence interval 2.46-12.1, P?<?0.001) after adjustment for multiple HF risk factors and potential confounders.In conclusion, NAFLD was independently associated with higher 1-year rehospitalization in patients hospitalized for acute HF.
0025-7974
e2760
Valbusa, F.
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Bonapace, S.
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Grillo, C.
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Scala, L.
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Chiampan, A.
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Rossi, A.
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Zoppini, G.
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Lonardo, A.
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Arcaro, G.
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Byrne, C.D.
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Targher, G.
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Valbusa, F.
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Bonapace, S.
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Grillo, C.
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Scala, L.
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Chiampan, A.
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Rossi, A.
3139960d-02f0-444c-a7de-aa834513656a
Zoppini, G.
21719d3f-197a-43ba-a955-366ea9ac0764
Lonardo, A.
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Arcaro, G.
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Byrne, C.D.
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Targher, G.
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Valbusa, F., Bonapace, S., Grillo, C., Scala, L., Chiampan, A., Rossi, A., Zoppini, G., Lonardo, A., Arcaro, G., Byrne, C.D. and Targher, G. (2016) Nonalcoholic fatty liver disease is associated with higher 1-year all-cause rehospitalization rates in patients admitted for acute heart failure. Medicine (Baltimore), 95 (7), e2760. (doi:10.1097/MD.0000000000002760). (PMID:26886619)

Record type: Article

Abstract

Repeat hospitalization due to acute heart failure (HF) is a global public health problem that markedly impacts on health resource use. Identifying novel predictors of rehospitalization would help physicians to determine the optimal postdischarge plan for preventing HF rehospitalization. Nonalcoholic fatty liver disease (NAFLD) is an emerging risk factor for many heart diseases, including HF. We assessed whether NAFLD at hospital admission predicts 1-year all-cause rehospitalization in patients with acute HF.We enrolled all patients consecutively admitted for acute HF to our General Medicine Division, from January 2013 to April 2014, after excluding patients with acute myocardial infarction, severe heart valve diseases, malignancy, known liver diseases, and those with volume overload related to extracardiac causes. NAFLD was diagnosed by ultrasonography and exclusion of competing etiologies. The primary outcome of the study was the 1-year all-cause rehospitalization rate.Among the 107 patients enrolled in the study, the cumulative rehospitalization rate was 12.1% at 1 month, 25.2% at 3 months, 29.9% at 6 months, and 38.3% at 1 year. Patients with NAFLD had markedly higher 1-year rehospitalization rates than those without NAFLD (58% vs 21% at 1 y; P?<?0.001 by the log-rank test). Cox regression analysis revealed that NAFLD was associated with a 5.5-fold increased risk of rehospitalization (adjusted hazard ratio 5.56, 95% confidence interval 2.46-12.1, P?<?0.001) after adjustment for multiple HF risk factors and potential confounders.In conclusion, NAFLD was independently associated with higher 1-year rehospitalization in patients hospitalized for acute HF.

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Published date: February 2016
Organisations: Human Development & Health

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Local EPrints ID: 388290
URI: http://eprints.soton.ac.uk/id/eprint/388290
ISSN: 0025-7974
PURE UUID: 9d3d1d63-0b9f-4ba3-bf03-a5de6387260d
ORCID for C.D. Byrne: ORCID iD orcid.org/0000-0001-6322-7753

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Date deposited: 23 Feb 2016 11:31
Last modified: 17 Dec 2019 01:53

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Contributors

Author: F. Valbusa
Author: S. Bonapace
Author: C. Grillo
Author: L. Scala
Author: A. Chiampan
Author: A. Rossi
Author: G. Zoppini
Author: A. Lonardo
Author: G. Arcaro
Author: C.D. Byrne ORCID iD
Author: G. Targher

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