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Dual-gate polysilicon nanoribbon biosensors enable high sensitivity detection of proteins

Dual-gate polysilicon nanoribbon biosensors enable high sensitivity detection of proteins
Dual-gate polysilicon nanoribbon biosensors enable high sensitivity detection of proteins
We demonstrate the advantages of dual-gate polysilicon nanoribbon biosensors with a comprehensive evaluation of different measurement schemes for pH and protein sensing. In particular, we compare the detection of voltage and current changes when top- and bottom-gate bias is applied. Measurements of pH show that a large voltage shift of 491 mV pH-1 is obtained in the subthreshold region when the top-gate is kept at a fixed potential and the bottom-gate is varied (voltage sweep). This is an improvement of 16 times over the 30 mV pH-1 measured using a top-gate sweep with the bottom-gate at a fixed potential. A similar large voltage shift of 175 mV is obtained when the protein avidin is sensed using a bottom-gate sweep. This is an improvement of 20 times compared with the 8.8 mV achieved from a top-gate sweep. Current measurements using bottom-gate sweeps do not deliver the same signal amplification as when using bottom-gate sweeps to measure voltage shifts. Thus, for detecting a small signal change on protein binding, it is advantageous to employ a double-gate transistor and to measure a voltage shift using a bottom-gate sweep. For top-gate sweeps, the use of a dual-gate transistor enables the current sensitivity to be enhanced by applying a negative bias to the bottom-gate to reduce the carrier concentration in the nanoribbon. For pH measurements, the current sensitivity increases from 65% to 149% and for avidin sensing it increases from 1.4% to 2.5%.
0957-4484
1-8
Zeimpekis, Ioannis
a2c354ec-3891-497c-adac-89b3a5d96af0
Sun, Kai
2ace53c1-82cc-47e5-911e-898b143163d3
Hu, Chunxiao
4892b566-6809-42a8-8285-1c1e93aac730
Ditshego, Nonofo
60dbad8f-c435-4f1d-a725-17a13b072796
Owain, Thomas
2eb3052c-6c49-4ae9-8734-8f48027fe912
de Planque, Maurits R.R.
a1d33d13-f516-44fb-8d2c-c51d18bc21ba
Chong, Harold M.H.
795aa67f-29e5-480f-b1bc-9bd5c0d558e1
Morgan, Hywel
de00d59f-a5a2-48c4-a99a-1d5dd7854174
Ashburn, Peter
68cef6b7-205b-47aa-9efb-f1f09f5c1038
Zeimpekis, Ioannis
a2c354ec-3891-497c-adac-89b3a5d96af0
Sun, Kai
2ace53c1-82cc-47e5-911e-898b143163d3
Hu, Chunxiao
4892b566-6809-42a8-8285-1c1e93aac730
Ditshego, Nonofo
60dbad8f-c435-4f1d-a725-17a13b072796
Owain, Thomas
2eb3052c-6c49-4ae9-8734-8f48027fe912
de Planque, Maurits R.R.
a1d33d13-f516-44fb-8d2c-c51d18bc21ba
Chong, Harold M.H.
795aa67f-29e5-480f-b1bc-9bd5c0d558e1
Morgan, Hywel
de00d59f-a5a2-48c4-a99a-1d5dd7854174
Ashburn, Peter
68cef6b7-205b-47aa-9efb-f1f09f5c1038

Zeimpekis, Ioannis, Sun, Kai, Hu, Chunxiao, Ditshego, Nonofo, Owain, Thomas, de Planque, Maurits R.R., Chong, Harold M.H., Morgan, Hywel and Ashburn, Peter (2016) Dual-gate polysilicon nanoribbon biosensors enable high sensitivity detection of proteins. Nanotechnology, 27 (16), 1-8. (doi:10.1088/0957-4484/27/16/165502).

Record type: Article

Abstract

We demonstrate the advantages of dual-gate polysilicon nanoribbon biosensors with a comprehensive evaluation of different measurement schemes for pH and protein sensing. In particular, we compare the detection of voltage and current changes when top- and bottom-gate bias is applied. Measurements of pH show that a large voltage shift of 491 mV pH-1 is obtained in the subthreshold region when the top-gate is kept at a fixed potential and the bottom-gate is varied (voltage sweep). This is an improvement of 16 times over the 30 mV pH-1 measured using a top-gate sweep with the bottom-gate at a fixed potential. A similar large voltage shift of 175 mV is obtained when the protein avidin is sensed using a bottom-gate sweep. This is an improvement of 20 times compared with the 8.8 mV achieved from a top-gate sweep. Current measurements using bottom-gate sweeps do not deliver the same signal amplification as when using bottom-gate sweeps to measure voltage shifts. Thus, for detecting a small signal change on protein binding, it is advantageous to employ a double-gate transistor and to measure a voltage shift using a bottom-gate sweep. For top-gate sweeps, the use of a dual-gate transistor enables the current sensitivity to be enhanced by applying a negative bias to the bottom-gate to reduce the carrier concentration in the nanoribbon. For pH measurements, the current sensitivity increases from 65% to 149% and for avidin sensing it increases from 1.4% to 2.5%.

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Accepted/In Press date: 18 February 2016
e-pub ahead of print date: 8 March 2016
Published date: 8 March 2016
Organisations: Nanoelectronics and Nanotechnology

Identifiers

Local EPrints ID: 388330
URI: https://eprints.soton.ac.uk/id/eprint/388330
ISSN: 0957-4484
PURE UUID: 6f2b42a9-dfc6-44a1-80ba-7baf20fa7540
ORCID for Maurits R.R. de Planque: ORCID iD orcid.org/0000-0002-8787-0513
ORCID for Harold M.H. Chong: ORCID iD orcid.org/0000-0002-7110-5761
ORCID for Hywel Morgan: ORCID iD orcid.org/0000-0003-4850-5676

Catalogue record

Date deposited: 23 Feb 2016 16:53
Last modified: 10 Sep 2019 05:33

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