Computational modelling of fatty acid transport in the human placenta
Computational modelling of fatty acid transport in the human placenta
Fatty acids are critical for normal fetal growth and development. The placenta mediates the transfer of fatty acids from the maternal to the fetal circulation. Yet, the mechanisms of fatty acid transport are not fully understood. The development of a computational model alongside experiments will test our understanding of the transfer mechanisms. Modelling experimental data suggest the presence of a metabolic pool within placental tissue that could represent the rate-limiting factor for fatty acid transfer. In addition the model suggests a slower flux capacity of the fetal-side of the placenta compared with the maternal-side. The model provides key insights into placental fatty acid transfer which will form the basis for future experimentation
8054-8057
Perazzolo, S.
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Hirschmugl, B.
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Wadsack, C.
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Desoye, G.
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Lewis, R
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Sengers, B. G.
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August 2015
Perazzolo, S.
bc5e3f83-6eb6-4ed6-9173-860a2d03817d
Hirschmugl, B.
eef8eb68-468e-4d4a-a021-ed473e222640
Wadsack, C.
d0095545-576d-46d1-9519-ba72f707a8ab
Desoye, G.
34a61ad7-4250-484e-a5ce-dbb980eee8cc
Lewis, R
caaeb97d-ea69-4f7b-8adb-5fa25e2d3502
Sengers, B. G.
d6b771b1-4ede-48c5-9644-fa86503941aa
Perazzolo, S., Hirschmugl, B., Wadsack, C., Desoye, G., Lewis, R and Sengers, B. G.
(2015)
Computational modelling of fatty acid transport in the human placenta.
Engineering in Medicine and Biology Society (EMBC), 2015 37th Annual International Conference of the IEEE, Milano, Italy.
25 - 29 Aug 2015.
.
(doi:10.1109/EMBC.2015.7320262).
Record type:
Conference or Workshop Item
(Paper)
Abstract
Fatty acids are critical for normal fetal growth and development. The placenta mediates the transfer of fatty acids from the maternal to the fetal circulation. Yet, the mechanisms of fatty acid transport are not fully understood. The development of a computational model alongside experiments will test our understanding of the transfer mechanisms. Modelling experimental data suggest the presence of a metabolic pool within placental tissue that could represent the rate-limiting factor for fatty acid transfer. In addition the model suggests a slower flux capacity of the fetal-side of the placenta compared with the maternal-side. The model provides key insights into placental fatty acid transfer which will form the basis for future experimentation
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Published date: August 2015
Venue - Dates:
Engineering in Medicine and Biology Society (EMBC), 2015 37th Annual International Conference of the IEEE, Milano, Italy, 2015-08-25 - 2015-08-29
Organisations:
Faculty of Medicine, Bioengineering Group, Engineering Science Unit
Identifiers
Local EPrints ID: 388502
URI: http://eprints.soton.ac.uk/id/eprint/388502
PURE UUID: c9ac786e-8375-4417-a3eb-d6800127d8c4
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Date deposited: 26 Feb 2016 14:59
Last modified: 15 Mar 2024 03:26
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Contributors
Author:
S. Perazzolo
Author:
B. Hirschmugl
Author:
C. Wadsack
Author:
G. Desoye
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