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Computational modelling of fatty acid transport in the human placenta

Computational modelling of fatty acid transport in the human placenta
Computational modelling of fatty acid transport in the human placenta
Fatty acids are critical for normal fetal growth and development. The placenta mediates the transfer of fatty acids from the maternal to the fetal circulation. Yet, the mechanisms of fatty acid transport are not fully understood. The development of a computational model alongside experiments will test our understanding of the transfer mechanisms. Modelling experimental data suggest the presence of a metabolic pool within placental tissue that could represent the rate-limiting factor for fatty acid transfer. In addition the model suggests a slower flux capacity of the fetal-side of the placenta compared with the maternal-side. The model provides key insights into placental fatty acid transfer which will form the basis for future experimentation
8054-8057
Perazzolo, S.
bc5e3f83-6eb6-4ed6-9173-860a2d03817d
Hirschmugl, B.
eef8eb68-468e-4d4a-a021-ed473e222640
Wadsack, C.
d0095545-576d-46d1-9519-ba72f707a8ab
Desoye, G.
34a61ad7-4250-484e-a5ce-dbb980eee8cc
Lewis, R
caaeb97d-ea69-4f7b-8adb-5fa25e2d3502
Sengers, B. G.
d6b771b1-4ede-48c5-9644-fa86503941aa
Perazzolo, S.
bc5e3f83-6eb6-4ed6-9173-860a2d03817d
Hirschmugl, B.
eef8eb68-468e-4d4a-a021-ed473e222640
Wadsack, C.
d0095545-576d-46d1-9519-ba72f707a8ab
Desoye, G.
34a61ad7-4250-484e-a5ce-dbb980eee8cc
Lewis, R
caaeb97d-ea69-4f7b-8adb-5fa25e2d3502
Sengers, B. G.
d6b771b1-4ede-48c5-9644-fa86503941aa

Perazzolo, S., Hirschmugl, B., Wadsack, C., Desoye, G., Lewis, R and Sengers, B. G. (2015) Computational modelling of fatty acid transport in the human placenta. Engineering in Medicine and Biology Society (EMBC), 2015 37th Annual International Conference of the IEEE, Milano, Italy. 24 - 28 Aug 2015. pp. 8054-8057 . (doi:10.1109/EMBC.2015.7320262).

Record type: Conference or Workshop Item (Paper)

Abstract

Fatty acids are critical for normal fetal growth and development. The placenta mediates the transfer of fatty acids from the maternal to the fetal circulation. Yet, the mechanisms of fatty acid transport are not fully understood. The development of a computational model alongside experiments will test our understanding of the transfer mechanisms. Modelling experimental data suggest the presence of a metabolic pool within placental tissue that could represent the rate-limiting factor for fatty acid transfer. In addition the model suggests a slower flux capacity of the fetal-side of the placenta compared with the maternal-side. The model provides key insights into placental fatty acid transfer which will form the basis for future experimentation

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More information

Published date: August 2015
Venue - Dates: Engineering in Medicine and Biology Society (EMBC), 2015 37th Annual International Conference of the IEEE, Milano, Italy, 2015-08-24 - 2015-08-28
Organisations: Faculty of Medicine, Bioengineering Group, Engineering Science Unit

Identifiers

Local EPrints ID: 388502
URI: http://eprints.soton.ac.uk/id/eprint/388502
PURE UUID: c9ac786e-8375-4417-a3eb-d6800127d8c4
ORCID for R Lewis: ORCID iD orcid.org/0000-0003-4044-9104
ORCID for B. G. Sengers: ORCID iD orcid.org/0000-0001-5859-6984

Catalogue record

Date deposited: 26 Feb 2016 14:59
Last modified: 18 Feb 2021 17:07

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Contributors

Author: S. Perazzolo
Author: B. Hirschmugl
Author: C. Wadsack
Author: G. Desoye
Author: R Lewis ORCID iD
Author: B. G. Sengers ORCID iD

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