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Allergy and asthma prevention 2014

Allergy and asthma prevention 2014
Allergy and asthma prevention 2014
Asthma and allergic diseases have become one of the epidemics of the 21st century in developed countries. Much of the success of other areas of medicine, such as infectious diseases, lies on preventive measures. Thus, much effort is also being placed lately in the prevention of asthma and allergy. This manuscript reviews the current evidence, divided into four areas of activity. Interventions modifying environmental exposure to allergens have provided inconsistent results, with multifaceted interventions being more effective in the prevention of asthma. Regarding nutrition, the use of hydrolyzed formulas in high-risk infants reduces the incidence of atopic dermatitis, while there is for now not enough evidence to recommend other dietary modifications, prebiotics, probiotics, or other microbial products. Pharmacologic agents used until now for prevention have not proved useful, while there is hope that antiviral vaccines could be useful in the future. Allergen-specific immunotherapy is effective for the treatment of allergic patients with symptoms; the study of its value for primary and secondary prevention of asthma and allergy is in its very preliminary phases. The lack of success in the prevention of these disorders lies on their complexity, which involves many genetic, epigenetic, and environmental interactions. There is a need to identify target populations, involved mechanisms and interactions, and the best interventions. These must be effective, feasible, implementable, and affordable.
allergy, asthma, atopic dermatitis, avoidance, environment, food allergy, immunotherapy, nutrition, prebiotics, probiotics, prevention, risk factors
0905-6157
516-533
Nieto, Antonio
a2936b3d-23ae-441c-ab62-17c648468b2e
Wahn, Ulrich
902b5866-4133-4792-93e6-27c4d9dc9f1f
Bufe, Albrecht
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Eigenmann, Philippe
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Halken, Susanne
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Hedlin, Gunilla
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Høst, Arne
dc3028ed-43bf-41c6-ae2e-115254e48210
Hourihane, Jonathan
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Just, Jocelyne
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Lack, Gideon
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Lau, Susanne
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Matricardi, Paolo Maria
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Muraro, Antonella
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Papadopoulos, Nikos
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Roberts, Graham
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Simpson, Angela
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Valovirta, Erkka
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Weidinger, Stephan
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Wickman, Magnus
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Mazon, Angel
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Nieto, Antonio
a2936b3d-23ae-441c-ab62-17c648468b2e
Wahn, Ulrich
902b5866-4133-4792-93e6-27c4d9dc9f1f
Bufe, Albrecht
759b0958-6cbe-4236-b9f9-f72e35e621cd
Eigenmann, Philippe
3e63730f-7e33-412f-9e2d-64d607922647
Halken, Susanne
2d3b1100-70d1-46e1-8466-15990d478a9f
Hedlin, Gunilla
09e3d406-6441-47ec-b4fa-860e6de096fb
Høst, Arne
dc3028ed-43bf-41c6-ae2e-115254e48210
Hourihane, Jonathan
6410730b-08ea-4fd3-8187-f2539a0dfd33
Just, Jocelyne
ae1fd282-3151-40c8-810b-5d57988e305b
Lack, Gideon
cac030a2-c358-4880-a91d-d67d06e8e321
Lau, Susanne
66bbde71-a61f-42fa-8ddb-8a94edcb1017
Matricardi, Paolo Maria
d326bdfc-76a3-4703-bf3a-6ea8f0db40cc
Muraro, Antonella
c554bef5-502b-4540-a6f0-a3f7c37f0075
Papadopoulos, Nikos
5a97e879-b2de-49aa-94c0-57160141b2fe
Roberts, Graham
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3
Simpson, Angela
5591f945-0ead-46a3-a866-b7bea84a2a83
Valovirta, Erkka
ef88c572-ca23-4dce-8026-0b0e142ab024
Weidinger, Stephan
2fc1ccff-ffe9-4347-8953-8581ec51ae9b
Wickman, Magnus
14ed9eaf-8409-47c1-bf53-ec3d72adb134
Mazon, Angel
232cd8e0-85a2-4410-a2a8-162c299128e3

Nieto, Antonio, Wahn, Ulrich, Bufe, Albrecht, Eigenmann, Philippe, Halken, Susanne, Hedlin, Gunilla, Høst, Arne, Hourihane, Jonathan, Just, Jocelyne, Lack, Gideon, Lau, Susanne, Matricardi, Paolo Maria, Muraro, Antonella, Papadopoulos, Nikos, Roberts, Graham, Simpson, Angela, Valovirta, Erkka, Weidinger, Stephan, Wickman, Magnus and Mazon, Angel (2014) Allergy and asthma prevention 2014. Pediatric Allergy and Immunology, 25 (6), 516-533. (doi:10.1111/pai.12272). (PMID:25224992)

Record type: Article

Abstract

Asthma and allergic diseases have become one of the epidemics of the 21st century in developed countries. Much of the success of other areas of medicine, such as infectious diseases, lies on preventive measures. Thus, much effort is also being placed lately in the prevention of asthma and allergy. This manuscript reviews the current evidence, divided into four areas of activity. Interventions modifying environmental exposure to allergens have provided inconsistent results, with multifaceted interventions being more effective in the prevention of asthma. Regarding nutrition, the use of hydrolyzed formulas in high-risk infants reduces the incidence of atopic dermatitis, while there is for now not enough evidence to recommend other dietary modifications, prebiotics, probiotics, or other microbial products. Pharmacologic agents used until now for prevention have not proved useful, while there is hope that antiviral vaccines could be useful in the future. Allergen-specific immunotherapy is effective for the treatment of allergic patients with symptoms; the study of its value for primary and secondary prevention of asthma and allergy is in its very preliminary phases. The lack of success in the prevention of these disorders lies on their complexity, which involves many genetic, epigenetic, and environmental interactions. There is a need to identify target populations, involved mechanisms and interactions, and the best interventions. These must be effective, feasible, implementable, and affordable.

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More information

Accepted/In Press date: 9 April 2014
e-pub ahead of print date: 15 September 2014
Published date: October 2014
Keywords: allergy, asthma, atopic dermatitis, avoidance, environment, food allergy, immunotherapy, nutrition, prebiotics, probiotics, prevention, risk factors
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 388689
URI: http://eprints.soton.ac.uk/id/eprint/388689
ISSN: 0905-6157
PURE UUID: ca811dc2-278f-47ec-9372-6922807adb77
ORCID for Graham Roberts: ORCID iD orcid.org/0000-0003-2252-1248

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Date deposited: 02 Mar 2016 09:52
Last modified: 15 Mar 2024 03:22

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Contributors

Author: Antonio Nieto
Author: Ulrich Wahn
Author: Albrecht Bufe
Author: Philippe Eigenmann
Author: Susanne Halken
Author: Gunilla Hedlin
Author: Arne Høst
Author: Jonathan Hourihane
Author: Jocelyne Just
Author: Gideon Lack
Author: Susanne Lau
Author: Paolo Maria Matricardi
Author: Antonella Muraro
Author: Nikos Papadopoulos
Author: Graham Roberts ORCID iD
Author: Angela Simpson
Author: Erkka Valovirta
Author: Stephan Weidinger
Author: Magnus Wickman
Author: Angel Mazon

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