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Osteoarthritis and frailty in elderly individuals across six European countries: results from the European Project on Osteoarthritis (EPOSA)

Osteoarthritis and frailty in elderly individuals across six European countries: results from the European Project on Osteoarthritis (EPOSA)
Osteoarthritis and frailty in elderly individuals across six European countries: results from the European Project on Osteoarthritis (EPOSA)
BACKGROUND: Osteoarthritis (OA) is the most common cause of disability in the elderly. Clinical frailty is associated with high mortality, but few studies have explored the relationship between OA and frailty. The objective of this study was to consider the association between OA and frailty/pre-frailty in an elderly population comprised of six European cohorts participating in the EPOSA project.

METHODS: Longitudinal study using baseline data and first follow-up waves, from EPOSA; 2,455 individuals aged 65-85 years were recruited from pre-existing population-based cohorts in Germany, Italy, the Netherlands, Spain, Sweden and the United Kingdom. Data were collected on clinical OA at any site (hand, knee or hip), based on the clinical classification criteria developed by the American College of Rheumatology (ACR). Frailty was defined according to Fried's criteria. The covariates considered were age, gender, educational level, obesity and country. We used multinomial logistic regression to analyse the associations between OA, frailty/pre-frailty and other covariates.

RESULTS: The overall prevalence of clinical OA at any site was 30.4 % (95 % CI:28.6-32.2); frailty was present in 10.2 % (95 % CI:9.0-11.4) and pre-frailty in 51.0 % (95 % CI:49.0-53.0). The odds of frailty was 2.96 (95 % CI:2.11-4.16) and pre-frailty 1.54 (95 % CI:1.24-1.91) as high among OA individuals than those without OA. The association remained when Knee OA, hip OA or hand OA were considered separately, and was stronger in those with increasing number of joints.

CONCLUSIONS: Clinical OA is associated with frailty and pre-frailty in older adults in European countries. This association might be considered when designing appropriate intervention strategies for OA management.
european, older people, osteoarthritis, frailty, prevalence
1-8
Castell, M.V.
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van der Pas, S.
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Otero, A.
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Siviero, P.
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Dennison, E.
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Denkinger, M.
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Pedersen, N.
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Sanchez-Martinez, M.
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Queipo, R.
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van Schoor, N.
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Zambon, S.
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Edwards, M.
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Peter, R.
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Schaap, L.
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Deeg, D.
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Castell, M.V.
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van der Pas, S.
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Otero, A.
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Siviero, P.
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Dennison, E.
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Denkinger, M.
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Pedersen, N.
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Sanchez-Martinez, M.
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Queipo, R.
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van Schoor, N.
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Zambon, S.
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Edwards, M.
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Peter, R.
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Schaap, L.
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Deeg, D.
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Castell, M.V., van der Pas, S., Otero, A., Siviero, P., Dennison, E., Denkinger, M., Pedersen, N., Sanchez-Martinez, M., Queipo, R., van Schoor, N., Zambon, S., Edwards, M., Peter, R., Schaap, L. and Deeg, D. (2015) Osteoarthritis and frailty in elderly individuals across six European countries: results from the European Project on Osteoarthritis (EPOSA). BMC Musculoskeletal Disorders, 16 (359), 1-8. (doi:10.1186/s12891-015-0807-8). (PMID:26578262)

Record type: Article

Abstract

BACKGROUND: Osteoarthritis (OA) is the most common cause of disability in the elderly. Clinical frailty is associated with high mortality, but few studies have explored the relationship between OA and frailty. The objective of this study was to consider the association between OA and frailty/pre-frailty in an elderly population comprised of six European cohorts participating in the EPOSA project.

METHODS: Longitudinal study using baseline data and first follow-up waves, from EPOSA; 2,455 individuals aged 65-85 years were recruited from pre-existing population-based cohorts in Germany, Italy, the Netherlands, Spain, Sweden and the United Kingdom. Data were collected on clinical OA at any site (hand, knee or hip), based on the clinical classification criteria developed by the American College of Rheumatology (ACR). Frailty was defined according to Fried's criteria. The covariates considered were age, gender, educational level, obesity and country. We used multinomial logistic regression to analyse the associations between OA, frailty/pre-frailty and other covariates.

RESULTS: The overall prevalence of clinical OA at any site was 30.4 % (95 % CI:28.6-32.2); frailty was present in 10.2 % (95 % CI:9.0-11.4) and pre-frailty in 51.0 % (95 % CI:49.0-53.0). The odds of frailty was 2.96 (95 % CI:2.11-4.16) and pre-frailty 1.54 (95 % CI:1.24-1.91) as high among OA individuals than those without OA. The association remained when Knee OA, hip OA or hand OA were considered separately, and was stronger in those with increasing number of joints.

CONCLUSIONS: Clinical OA is associated with frailty and pre-frailty in older adults in European countries. This association might be considered when designing appropriate intervention strategies for OA management.

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Accepted/In Press date: 6 November 2015
e-pub ahead of print date: 17 November 2015
Published date: 17 November 2015
Keywords: european, older people, osteoarthritis, frailty, prevalence
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 388712
URI: https://eprints.soton.ac.uk/id/eprint/388712
PURE UUID: abac3962-5cb9-478a-a8ec-122f900fa313
ORCID for E. Dennison: ORCID iD orcid.org/0000-0002-3048-4961

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Date deposited: 02 Mar 2016 11:55
Last modified: 15 Aug 2019 00:53

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Contributors

Author: M.V. Castell
Author: S. van der Pas
Author: A. Otero
Author: P. Siviero
Author: E. Dennison ORCID iD
Author: M. Denkinger
Author: N. Pedersen
Author: M. Sanchez-Martinez
Author: R. Queipo
Author: N. van Schoor
Author: S. Zambon
Author: M. Edwards
Author: R. Peter
Author: L. Schaap
Author: D. Deeg

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