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The epidemiology of anaphylaxis in Europe: a systematic review

The epidemiology of anaphylaxis in Europe: a systematic review
The epidemiology of anaphylaxis in Europe: a systematic review
BACKGROUND: Anaphylaxis is an acute, potentially fatal, multi-organ system, allergic reaction caused by the release of chemical mediators from mast cells and basophils. Uncertainty exists around epidemiological measures of incidence and prevalence, risk factors, risk of recurrence, and death due to anaphylaxis. This systematic review aimed to (1) understand and describe the epidemiology of anaphylaxis and (2) describe how these characteristics vary by person, place, and time.

METHODS: Using a highly sensitive search strategy, we identified systematic reviews of epidemiological studies, descriptive and analytical epidemiological investigations, and studies involving analysis of routine data.

RESULTS: Our searches identified a total of 5,843 potentially eligible studies, of which 49 satisfied our inclusion criteria. Of these, three were suitable for pooled estimates of prevalence. The incidence rates for all-cause anaphylaxis ranged from 1.5 to 7.9 per 100,000 person-years. These data indicated that an estimated 0.3% (95% CI 0.1-0.5) of the population experience anaphylaxis at some point in their lives. Food, drugs, stinging insects, and latex were the most commonly identified triggers.

CONCLUSIONS: Anaphylaxis is a common problem, affecting an estimated 1 in 300 of the European population at some time in their lives. Future research needs to focus on better understanding of the trends across Europe and identifying those most likely to experience fatal reactions.
anaphylaxis, epidemiology, incidence, prevalence, risk factors
0105-4538
1353-1361
Panesar, S.S.
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Javad, S.
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de Silva, D.
aef581f3-ada5-4cba-8c6c-84ae0b2f2b17
Nwaru, B.I.
33533f93-b388-49cf-b725-54d8977a4028
Hickstein, L.
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Muraro, A.
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Roberts, G.
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Worm, M.
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Bilò, M.B.
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Cardona, V.
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Dubois, A.E.J.
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Dunn Galvin, A.
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Eigenmann, P.
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Fernandez-Rivas, M.
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Halken, S.
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Lack, G.
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Niggemann, B.
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Santos, A.F.
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Vlieg-Boerstra, B.J.
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Zolkipli, Z.Q.
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Sheikh, A.
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Panesar, S.S.
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Javad, S.
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de Silva, D.
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Nwaru, B.I.
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Hickstein, L.
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Muraro, A.
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Roberts, G.
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Worm, M.
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Bilò, M.B.
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Cardona, V.
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Dubois, A.E.J.
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Dunn Galvin, A.
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Eigenmann, P.
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Fernandez-Rivas, M.
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Halken, S.
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Lack, G.
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Niggemann, B.
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Santos, A.F.
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Vlieg-Boerstra, B.J.
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Zolkipli, Z.Q.
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Sheikh, A.
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Panesar, S.S., Javad, S., de Silva, D., Nwaru, B.I., Hickstein, L., Muraro, A., Roberts, G., Worm, M., Bilò, M.B., Cardona, V., Dubois, A.E.J., Dunn Galvin, A., Eigenmann, P., Fernandez-Rivas, M., Halken, S., Lack, G., Niggemann, B., Santos, A.F., Vlieg-Boerstra, B.J., Zolkipli, Z.Q. and Sheikh, A. (2013) The epidemiology of anaphylaxis in Europe: a systematic review. Allergy, 68 (11), 1353-1361. (doi:10.1111/all.12272). (PMID:24117770)

Record type: Article

Abstract

BACKGROUND: Anaphylaxis is an acute, potentially fatal, multi-organ system, allergic reaction caused by the release of chemical mediators from mast cells and basophils. Uncertainty exists around epidemiological measures of incidence and prevalence, risk factors, risk of recurrence, and death due to anaphylaxis. This systematic review aimed to (1) understand and describe the epidemiology of anaphylaxis and (2) describe how these characteristics vary by person, place, and time.

METHODS: Using a highly sensitive search strategy, we identified systematic reviews of epidemiological studies, descriptive and analytical epidemiological investigations, and studies involving analysis of routine data.

RESULTS: Our searches identified a total of 5,843 potentially eligible studies, of which 49 satisfied our inclusion criteria. Of these, three were suitable for pooled estimates of prevalence. The incidence rates for all-cause anaphylaxis ranged from 1.5 to 7.9 per 100,000 person-years. These data indicated that an estimated 0.3% (95% CI 0.1-0.5) of the population experience anaphylaxis at some point in their lives. Food, drugs, stinging insects, and latex were the most commonly identified triggers.

CONCLUSIONS: Anaphylaxis is a common problem, affecting an estimated 1 in 300 of the European population at some time in their lives. Future research needs to focus on better understanding of the trends across Europe and identifying those most likely to experience fatal reactions.

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More information

Accepted/In Press date: 23 August 2013
e-pub ahead of print date: 14 October 2013
Published date: November 2013
Keywords: anaphylaxis, epidemiology, incidence, prevalence, risk factors
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 388734
URI: http://eprints.soton.ac.uk/id/eprint/388734
ISSN: 0105-4538
PURE UUID: c1adf187-7289-427c-808f-9391872a8bf3
ORCID for G. Roberts: ORCID iD orcid.org/0000-0003-2252-1248

Catalogue record

Date deposited: 02 Mar 2016 16:14
Last modified: 09 Jan 2022 03:18

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Contributors

Author: S.S. Panesar
Author: S. Javad
Author: D. de Silva
Author: B.I. Nwaru
Author: L. Hickstein
Author: A. Muraro
Author: G. Roberts ORCID iD
Author: M. Worm
Author: M.B. Bilò
Author: V. Cardona
Author: A.E.J. Dubois
Author: A. Dunn Galvin
Author: P. Eigenmann
Author: M. Fernandez-Rivas
Author: S. Halken
Author: G. Lack
Author: B. Niggemann
Author: A.F. Santos
Author: B.J. Vlieg-Boerstra
Author: Z.Q. Zolkipli
Author: A. Sheikh

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