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The dangers of widespread nitric oxide screening for primary ciliary dyskinesia

The dangers of widespread nitric oxide screening for primary ciliary dyskinesia
The dangers of widespread nitric oxide screening for primary ciliary dyskinesia
Primary ciliary dyskinesia (PCD) is underdiagnosed and requires complex testing at specialist diagnostic centres. Measurement of nasal nitric oxide (nNO) has good sensitivity and specificity screening for PCD, but is currently usually measured at PCD centres rather than prior to referral. Proposals to include NO testing for asthma diagnoses could widen access to PCD screening if nasal mode analysers are available. Data from 282 consecutive referrals to our PCD diagnostic centre (31 PCD positive) were used to model predictive values for nNO testing with varying pretest probability and showed that predictive values were good in the referral population, but extending screening to more general populations would result in excessive false positives that may overwhelm diagnostic services. Although nNO remains a useful test, a 'normal' result with classical clinical history should still be considered for further testing.
asthma, exhaled airway markers, rare lung diseases
0040-6376
1-2
Collins, Samuel A.
3c35238c-dbbd-4021-b7fa-c5b89e471981
Behan, Laura
cf1a7b5e-64c5-4b02-8db2-7ad96781d40d
Harris, Amanda
7a93d66b-2959-40ea-b32d-dce642947951
Gove, Kerry
8f043bbb-080d-49b3-9ee5-046f3a636ee0
Lucas, Jane S.
5cb3546c-87b2-4e59-af48-402076e25313
Collins, Samuel A.
3c35238c-dbbd-4021-b7fa-c5b89e471981
Behan, Laura
cf1a7b5e-64c5-4b02-8db2-7ad96781d40d
Harris, Amanda
7a93d66b-2959-40ea-b32d-dce642947951
Gove, Kerry
8f043bbb-080d-49b3-9ee5-046f3a636ee0
Lucas, Jane S.
5cb3546c-87b2-4e59-af48-402076e25313

Collins, Samuel A., Behan, Laura, Harris, Amanda, Gove, Kerry and Lucas, Jane S. (2016) The dangers of widespread nitric oxide screening for primary ciliary dyskinesia. Thorax, 1-2. (doi:10.1136/thoraxjnl-2015-208056). (PMID:26896442)

Record type: Article

Abstract

Primary ciliary dyskinesia (PCD) is underdiagnosed and requires complex testing at specialist diagnostic centres. Measurement of nasal nitric oxide (nNO) has good sensitivity and specificity screening for PCD, but is currently usually measured at PCD centres rather than prior to referral. Proposals to include NO testing for asthma diagnoses could widen access to PCD screening if nasal mode analysers are available. Data from 282 consecutive referrals to our PCD diagnostic centre (31 PCD positive) were used to model predictive values for nNO testing with varying pretest probability and showed that predictive values were good in the referral population, but extending screening to more general populations would result in excessive false positives that may overwhelm diagnostic services. Although nNO remains a useful test, a 'normal' result with classical clinical history should still be considered for further testing.

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More information

Accepted/In Press date: 24 January 2016
Published date: 19 February 2016
Keywords: asthma, exhaled airway markers, rare lung diseases
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 388804
URI: https://eprints.soton.ac.uk/id/eprint/388804
ISSN: 0040-6376
PURE UUID: fea90b98-720e-4230-91bb-a2b800111247

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Date deposited: 03 Mar 2016 13:31
Last modified: 15 Jul 2019 20:43

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Contributors

Author: Samuel A. Collins
Author: Laura Behan
Author: Amanda Harris
Author: Kerry Gove
Author: Jane S. Lucas

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