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Nanoparticle–loaded protein–polymer nanodroplets for improved stability and conversion efficiency in ultrasound imaging and drug delivery

Nanoparticle–loaded protein–polymer nanodroplets for improved stability and conversion efficiency in ultrasound imaging and drug delivery
Nanoparticle–loaded protein–polymer nanodroplets for improved stability and conversion efficiency in ultrasound imaging and drug delivery
A new formulation of volatile nanodroplets stabilized by a protein and polymer coating and loaded with magnetic nanoparticles is developed. The droplets show enhanced stability and phase conversion efficiency upon ultrasound exposure compared with existing formulations. Magnetic targeting, encapsulation, and release of an anticancer drug are demonstrated in vitro with a 40% improvement in cytotoxicity compared with free drug.
breast cancer, chemotherapy, microbubbles, nanodroplets, ultrasound
1521-4095
5484-5492
Lee, Jeong Yu
25c5c704-f4ad-48ea-a984-088034dc3a93
Carugo, Dario
0a4be6cd-e309-4ed8-a620-20256ce01179
Crake, Calum
ab3eeead-4851-4c54-bea9-383cf136c4bb
Owen, Joshua
b5d9c311-b8d4-40db-b937-65a769a11b4f
de Saint Victor, Marie
b558a637-b7b6-4b5f-ad84-1a93f74a425e
Seth, Anjali
92f275f5-ebf6-4e76-9c16-d8438f765ca2
Coussios, Constantin
55b78f4c-f241-4676-87d5-9ea5fb295f4f
Stride, Eleanor
c0143e95-81fa-47c8-b9bc-5b4fc319bba6
Lee, Jeong Yu
25c5c704-f4ad-48ea-a984-088034dc3a93
Carugo, Dario
0a4be6cd-e309-4ed8-a620-20256ce01179
Crake, Calum
ab3eeead-4851-4c54-bea9-383cf136c4bb
Owen, Joshua
b5d9c311-b8d4-40db-b937-65a769a11b4f
de Saint Victor, Marie
b558a637-b7b6-4b5f-ad84-1a93f74a425e
Seth, Anjali
92f275f5-ebf6-4e76-9c16-d8438f765ca2
Coussios, Constantin
55b78f4c-f241-4676-87d5-9ea5fb295f4f
Stride, Eleanor
c0143e95-81fa-47c8-b9bc-5b4fc319bba6

Lee, Jeong Yu, Carugo, Dario, Crake, Calum, Owen, Joshua, de Saint Victor, Marie, Seth, Anjali, Coussios, Constantin and Stride, Eleanor (2015) Nanoparticle–loaded protein–polymer nanodroplets for improved stability and conversion efficiency in ultrasound imaging and drug delivery. Advanced Materials, 27 (37), 5484-5492. (doi:10.1002/adma.201502022). (PMID:26265592)

Record type: Article

Abstract

A new formulation of volatile nanodroplets stabilized by a protein and polymer coating and loaded with magnetic nanoparticles is developed. The droplets show enhanced stability and phase conversion efficiency upon ultrasound exposure compared with existing formulations. Magnetic targeting, encapsulation, and release of an anticancer drug are demonstrated in vitro with a 40% improvement in cytotoxicity compared with free drug.

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More information

Accepted/In Press date: 23 June 2015
e-pub ahead of print date: 11 August 2015
Published date: 7 October 2015
Keywords: breast cancer, chemotherapy, microbubbles, nanodroplets, ultrasound
Organisations: Bioengineering Group, Mechatronics, Engineering Science Unit, Faculty of Engineering and the Environment

Identifiers

Local EPrints ID: 389480
URI: http://eprints.soton.ac.uk/id/eprint/389480
ISSN: 1521-4095
PURE UUID: 4279654c-980f-477f-adc8-00b9dbf25d18

Catalogue record

Date deposited: 08 Mar 2016 10:25
Last modified: 09 Dec 2019 19:43

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Contributors

Author: Jeong Yu Lee
Author: Dario Carugo
Author: Calum Crake
Author: Joshua Owen
Author: Marie de Saint Victor
Author: Anjali Seth
Author: Constantin Coussios
Author: Eleanor Stride

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