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Global epidemiology of avian influenza A H5N1 virus infection in humans, 1997–2015: a systematic review of individual case data

Global epidemiology of avian influenza A H5N1 virus infection in humans, 1997–2015: a systematic review of individual case data
Global epidemiology of avian influenza A H5N1 virus infection in humans, 1997–2015: a systematic review of individual case data
Avian influenza A H5N1 viruses have caused many, typically severe, human infections since the first human case was reported in 1997. However, no comprehensive epidemiological analysis of global human cases of H5N1 from 1997 to 2015 exists. Moreover, few studies have examined in detail the changing epidemiology of human H5N1 cases in Egypt, especially given the outbreaks since November, 2014, which have the highest number of cases ever reported worldwide in a similar period. Data on individual patients were collated from different sources using a systematic approach to describe the global epidemiology of 907 human H5N1 cases between May, 1997, and April, 2015. The number of affected countries rose between 2003 and 2008, with expansion from east and southeast Asia, then to west Asia and Africa. Most cases (67·2%) occurred from December to March, and the overall case-fatality risk was 483 (53·5%) of 903 cases which varied across geographical regions. Although the incidence in Egypt has increased dramatically since November, 2014, compared with the cases beforehand, there were no significant differences in the fatality risk, history of exposure to poultry, history of patient contact, and time from onset to hospital admission in the recent cases.
1473-3099
Lai, S.
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Qin, Y.
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Cowling, B.J.
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Ren, X.
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Wardrop, N.
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Gilbert, M.
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Tsang, T.K.
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Wu, P.
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Feng, L.
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Jiang, H.
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Peng, Z.
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Zheng, J.
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Liao, Q.
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Li, S.
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Horby, P.W.
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Farrar, J.J.
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Gao, G.F.
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Tatem, A.
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Yu, H.
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Lai, S.
b57a5fe8-cfb6-4fa7-b414-a98bb891b001
Qin, Y.
2160ffe6-8697-40f8-9618-9d26dbc0a372
Cowling, B.J.
d4f3552d-f57a-4301-b088-14a85932ef61
Ren, X.
3794a392-595e-42b7-9485-2e6e960a86bf
Wardrop, N.
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Gilbert, M.
1783ad6f-c32e-46dd-8de0-eb0e139afce0
Tsang, T.K.
fde7aa84-3414-4019-b88c-029a5dc98f1e
Wu, P.
d20ce52b-0485-440a-836d-c4c98cf847e2
Feng, L.
35f4c3a0-e8ca-47b8-9649-5cf6d854e4ab
Jiang, H.
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Peng, Z.
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Zheng, J.
f4eb1be9-d452-4d15-aa3c-dbb94d21a50e
Liao, Q.
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Li, S.
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Horby, P.W.
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Farrar, J.J.
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Gao, G.F.
85f4ed55-4b51-4bcc-bb61-1f330bafbd76
Tatem, A.
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Yu, H.
d9fd98cc-1fd4-4f02-b1b0-9c301920ef1d

Lai, S., Qin, Y., Cowling, B.J., Ren, X., Wardrop, N., Gilbert, M., Tsang, T.K., Wu, P., Feng, L., Jiang, H., Peng, Z., Zheng, J., Liao, Q., Li, S., Horby, P.W., Farrar, J.J., Gao, G.F., Tatem, A. and Yu, H. (2016) Global epidemiology of avian influenza A H5N1 virus infection in humans, 1997–2015: a systematic review of individual case data. The Lancet Infectious Diseases. (doi:10.1016/S1473-3099(16)00153-5).

Record type: Article

Abstract

Avian influenza A H5N1 viruses have caused many, typically severe, human infections since the first human case was reported in 1997. However, no comprehensive epidemiological analysis of global human cases of H5N1 from 1997 to 2015 exists. Moreover, few studies have examined in detail the changing epidemiology of human H5N1 cases in Egypt, especially given the outbreaks since November, 2014, which have the highest number of cases ever reported worldwide in a similar period. Data on individual patients were collated from different sources using a systematic approach to describe the global epidemiology of 907 human H5N1 cases between May, 1997, and April, 2015. The number of affected countries rose between 2003 and 2008, with expansion from east and southeast Asia, then to west Asia and Africa. Most cases (67·2%) occurred from December to March, and the overall case-fatality risk was 483 (53·5%) of 903 cases which varied across geographical regions. Although the incidence in Egypt has increased dramatically since November, 2014, compared with the cases beforehand, there were no significant differences in the fatality risk, history of exposure to poultry, history of patient contact, and time from onset to hospital admission in the recent cases.

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Accepted/In Press date: 8 March 2016
e-pub ahead of print date: 18 May 2016
Organisations: WorldPop, Population, Health & Wellbeing (PHeW)

Identifiers

Local EPrints ID: 389605
URI: https://eprints.soton.ac.uk/id/eprint/389605
ISSN: 1473-3099
PURE UUID: b856de08-dfff-460c-a44d-6af965db0b8f
ORCID for S. Lai: ORCID iD orcid.org/0000-0001-9781-8148
ORCID for A. Tatem: ORCID iD orcid.org/0000-0002-7270-941X

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Date deposited: 11 Mar 2016 13:54
Last modified: 15 Aug 2019 00:36

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Contributors

Author: S. Lai ORCID iD
Author: Y. Qin
Author: B.J. Cowling
Author: X. Ren
Author: N. Wardrop
Author: M. Gilbert
Author: T.K. Tsang
Author: P. Wu
Author: L. Feng
Author: H. Jiang
Author: Z. Peng
Author: J. Zheng
Author: Q. Liao
Author: S. Li
Author: P.W. Horby
Author: J.J. Farrar
Author: G.F. Gao
Author: A. Tatem ORCID iD
Author: H. Yu

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