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A review of the potential health benefits of pine nut oil and its characteristic fatty acid pinolenic acid

A review of the potential health benefits of pine nut oil and its characteristic fatty acid pinolenic acid
A review of the potential health benefits of pine nut oil and its characteristic fatty acid pinolenic acid
Pine nuts contain pinolenic acid (PNLA) which represents 14-19% of fatty acids present. Here we review research on pine nut oil (PNO) and PNLA from studies performed in vitro, in animal models and in humans. PNLA has anti-inflammatory action and may improve lymphocyte function. PNO and PNLA have favourable effects on appetite control, perhaps by increasing the blood concentrations of key satiety hormones. Less weight gain and fat deposition were observed in mice fed with high fat diets containing PNO. In vitro research demonstrated that PNLA is a potent dual agonist for co-activation of free fatty acid receptor 1 and4, which could enhance glucose-dependent insulin secretion and insulin sensitivity. PNO increased the activity of antioxidant protective enzymes in serum and decreased the concentration of malondialdehyde, an indicator of lipid peroxidation. Thus, PNLA and its parent PNO could be of potential benefit to human health, although this requires further investigation.
pinolenic acid, p. koraiensis, p. sibirica, pine nut oil, health
1756-4646
464-473
Xie, K.
88f73105-c5d5-400c-b96f-d7a4168bb333
Miles, E.
20332899-ecdb-4214-95bc-922dde36d416
Calder, P.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Xie, K.
88f73105-c5d5-400c-b96f-d7a4168bb333
Miles, E.
20332899-ecdb-4214-95bc-922dde36d416
Calder, P.
1797e54f-378e-4dcb-80a4-3e30018f07a6

Xie, K., Miles, E. and Calder, P. (2016) A review of the potential health benefits of pine nut oil and its characteristic fatty acid pinolenic acid. Journal of Functional Foods, 23, 464-473. (doi:10.1016/j.jff.2016.03.003).

Record type: Article

Abstract

Pine nuts contain pinolenic acid (PNLA) which represents 14-19% of fatty acids present. Here we review research on pine nut oil (PNO) and PNLA from studies performed in vitro, in animal models and in humans. PNLA has anti-inflammatory action and may improve lymphocyte function. PNO and PNLA have favourable effects on appetite control, perhaps by increasing the blood concentrations of key satiety hormones. Less weight gain and fat deposition were observed in mice fed with high fat diets containing PNO. In vitro research demonstrated that PNLA is a potent dual agonist for co-activation of free fatty acid receptor 1 and4, which could enhance glucose-dependent insulin secretion and insulin sensitivity. PNO increased the activity of antioxidant protective enzymes in serum and decreased the concentration of malondialdehyde, an indicator of lipid peroxidation. Thus, PNLA and its parent PNO could be of potential benefit to human health, although this requires further investigation.

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__soton.ac.uk_ude_PersonalFiles_Users_lce_mydocuments_Eprints - Prof Calder_Xie et al Revised and corrected with figures.pdf - Accepted Manuscript
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More information

Accepted/In Press date: 2 March 2016
e-pub ahead of print date: 31 March 2016
Published date: May 2016
Keywords: pinolenic acid, p. koraiensis, p. sibirica, pine nut oil, health
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 389615
URI: http://eprints.soton.ac.uk/id/eprint/389615
ISSN: 1756-4646
PURE UUID: 1cab52f0-29d3-459b-aae7-c8613407d773
ORCID for E. Miles: ORCID iD orcid.org/0000-0002-8643-0655
ORCID for P. Calder: ORCID iD orcid.org/0000-0002-6038-710X

Catalogue record

Date deposited: 11 Mar 2016 14:02
Last modified: 11 Mar 2021 02:35

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