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Clinical implications of diffuse excessive high signal intensity (DEHSI) on neonatal MRI in school age children born extremely preterm

Clinical implications of diffuse excessive high signal intensity (DEHSI) on neonatal MRI in school age children born extremely preterm
Clinical implications of diffuse excessive high signal intensity (DEHSI) on neonatal MRI in school age children born extremely preterm
Objective: Magnetic resonance imaging (MRI) of the brain carried out during the neonatal period shows that 55–80% of extremely preterm infants display white matter diffuse excessive high signal intensity (DEHSI). Our aim was to study differences in developmental outcome at the age of 6.5 years in children born extremely preterm with and without DEHSI.

Study Design: This was a prospective cohort study of 83 children who were born in Stockholm, Sweden, between 2004 and 2007, born at gestational age of < 27 weeks + 0 days and who underwent an MRI scan of their brain at term equivalent age. The outcome measures at 6.5 years included testing 66 children with the modified Touwen neurology examination, the Movement Assessment Battery for Children 2, the Wechsler Intelligence Scale for Children—Fourth Edition, Beery Visual-motor Integration test—Sixth Edition, and the Strengths and Difficulties Questionnaire. Group-wise comparisons were done between children with and without DEHSI using Student t-test, Mann Whitney U test, Chi square test and regression analysis.

Results: DEHSI was detected in 39 (59%) of the 66 children who were assessed at 6.5 years. The presence of DEHSI was not associated with mild neurological dysfunction, scores on M-ABC assessment, cognition, visual-motor integration, or behavior at 6.5 years.

Conclusion: The presence of qualitatively defined DEHSI on neonatal MRI did not prove to be a useful predictor of long-term impairment in children born extremely preterm.
1932-6203
1-12
Broström, Lina
d2a1452b-eaa7-462b-be9c-134fcb1c8b4f
Bolk, Jenny
75195acc-b0ad-423f-bf0d-1893f2ee4371
Padilla, Nelly
795c7d8a-e73a-4949-887e-75f966d9aed6
Skiöld, Béatrice
e0462ec7-9993-47b5-92bb-3db4edf06d2d
Eklöf, Eva
91730abd-fdab-4fdf-9c4b-748e1a6360a8
Mårtensson, Gustaf
cfd74a15-9028-4eb4-9b01-e5ec5ded9e91
Ådén, Ulrika
4d84a0ab-ef6d-4cdc-9653-913f1c4f79f3
Broström, Lina
d2a1452b-eaa7-462b-be9c-134fcb1c8b4f
Bolk, Jenny
75195acc-b0ad-423f-bf0d-1893f2ee4371
Padilla, Nelly
795c7d8a-e73a-4949-887e-75f966d9aed6
Skiöld, Béatrice
e0462ec7-9993-47b5-92bb-3db4edf06d2d
Eklöf, Eva
91730abd-fdab-4fdf-9c4b-748e1a6360a8
Mårtensson, Gustaf
cfd74a15-9028-4eb4-9b01-e5ec5ded9e91
Ådén, Ulrika
4d84a0ab-ef6d-4cdc-9653-913f1c4f79f3

Broström, Lina, Bolk, Jenny, Padilla, Nelly, Skiöld, Béatrice, Eklöf, Eva, Mårtensson, Gustaf and Ådén, Ulrika (2016) Clinical implications of diffuse excessive high signal intensity (DEHSI) on neonatal MRI in school age children born extremely preterm. PLoS ONE, 11 (2), 1-12. (doi:10.1371/journal.pone.0149578). (PMID:26886451)

Record type: Article

Abstract

Objective: Magnetic resonance imaging (MRI) of the brain carried out during the neonatal period shows that 55–80% of extremely preterm infants display white matter diffuse excessive high signal intensity (DEHSI). Our aim was to study differences in developmental outcome at the age of 6.5 years in children born extremely preterm with and without DEHSI.

Study Design: This was a prospective cohort study of 83 children who were born in Stockholm, Sweden, between 2004 and 2007, born at gestational age of < 27 weeks + 0 days and who underwent an MRI scan of their brain at term equivalent age. The outcome measures at 6.5 years included testing 66 children with the modified Touwen neurology examination, the Movement Assessment Battery for Children 2, the Wechsler Intelligence Scale for Children—Fourth Edition, Beery Visual-motor Integration test—Sixth Edition, and the Strengths and Difficulties Questionnaire. Group-wise comparisons were done between children with and without DEHSI using Student t-test, Mann Whitney U test, Chi square test and regression analysis.

Results: DEHSI was detected in 39 (59%) of the 66 children who were assessed at 6.5 years. The presence of DEHSI was not associated with mild neurological dysfunction, scores on M-ABC assessment, cognition, visual-motor integration, or behavior at 6.5 years.

Conclusion: The presence of qualitatively defined DEHSI on neonatal MRI did not prove to be a useful predictor of long-term impairment in children born extremely preterm.

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More information

Accepted/In Press date: 1 February 2016
Published date: 17 February 2016
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 389654
URI: https://eprints.soton.ac.uk/id/eprint/389654
ISSN: 1932-6203
PURE UUID: 862723c9-d268-4a17-b979-a2e95c499648

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Date deposited: 11 Mar 2016 10:39
Last modified: 21 Aug 2017 16:32

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