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Reliability of motor evoked potential resting threshold and amplitude of proximal and distal arm muscles in healthy adults

Reliability of motor evoked potential resting threshold and amplitude of proximal and distal arm muscles in healthy adults
Reliability of motor evoked potential resting threshold and amplitude of proximal and distal arm muscles in healthy adults
Objectives: To quantify the intra-rater and test-retest reliability of the motor evoked potential (MEP) resting threshold (RT) and MEP amplitude of the anterior deltoid (AD) and extensor digitorum (ED) of healthy adults using Transcranial Magnetic Stimulation (TMS).

Methods: Stimulation was performed on healthy adults with a Magstim® 2002 device using Brainsight® neuro-navigation. Surface EMG (Biometrics Ltd) was recorded from surface electrodes over AD and ED muscles. RT was defined as the minimal TMS intensity to recruit an MEP > 50 ?V in five of ten consecutive measurements in both muscles. Measurements were made on three occasions in each participant by the same assessor. Two measurements were carried out on day one with 30 minutes rest in between (tests 1 and 2) and the third measurement was carried out three days later (test 3). Mean peak to peak amplitude of five MEPs at RT were analysed using MATLAB.

Results: Twenty participants (10 males and 10 females, mean age of 59.86 years ±11.70SD) completed the study. There was good to excellent reliability of RT for ED and AD between tests 1 and 2 (ICC=0.89 and 0.94 respectively) and tests 1 and 3 (ICC=0.84 and 0.77 respectively). MEP amplitude between tests 1 and 2 had a poor to moderate level of agreement (ICC=0.42 [ED] and 0.53 [AD]) and between tests 1 and 3, moderate to very poor agreement was found (ICC=0.62 [ED] and 0.14 [AD]).

Conclusions: RT and MEP amplitude are regularly used as neurophysiological outcome measures in neurorehabilitation research. Measurement of the RT showed excellent intra-rater and test-retest reliability in healthy adults. Measurement of MEP amplitude at RT of both muscles showed poor to moderate agreement. RT provides less information about changes in cortical excitability, however, our results suggest RT to be a more reliable neurophysiological measurement, which could be included in future neurorehabilitation trials.
Tedesco Triccas, L.
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Hughes, A.M.
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Burridge, J.H.
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Din, A.E.
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Warner, M.
f4dce73d-fb87-4f71-a3f0-078123aa040c
Brown, S.
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Desikan, M.
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Rothwell, J.C.
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Verheyden, G.
dd0095fa-83d8-4ffd-af2f-fcef6f8a3997
Tedesco Triccas, L.
f058cdf1-9976-4f4b-a872-39b8739ba1bc
Hughes, A.M.
11239f51-de47-4445-9a0d-5b82ddc11dea
Burridge, J.H.
0110e9ea-0884-4982-a003-cb6307f38f64
Din, A.E.
4ca3c758-ec41-4c76-baf6-95ad788f5336
Warner, M.
f4dce73d-fb87-4f71-a3f0-078123aa040c
Brown, S.
81f6a7a5-379f-4b86-8b55-39f9799c23c8
Desikan, M.
86520029-ab31-4fbc-b175-4158b59fcb67
Rothwell, J.C.
fea00de8-9734-4d9d-a017-c855f17df1c5
Verheyden, G.
dd0095fa-83d8-4ffd-af2f-fcef6f8a3997

Tedesco Triccas, L., Hughes, A.M., Burridge, J.H., Din, A.E., Warner, M., Brown, S., Desikan, M., Rothwell, J.C. and Verheyden, G. (2016) Reliability of motor evoked potential resting threshold and amplitude of proximal and distal arm muscles in healthy adults. 9th World Congress for Neurorehabilitation, Philadelphia, United States. 01 May 2016.

Record type: Conference or Workshop Item (Paper)

Abstract

Objectives: To quantify the intra-rater and test-retest reliability of the motor evoked potential (MEP) resting threshold (RT) and MEP amplitude of the anterior deltoid (AD) and extensor digitorum (ED) of healthy adults using Transcranial Magnetic Stimulation (TMS).

Methods: Stimulation was performed on healthy adults with a Magstim® 2002 device using Brainsight® neuro-navigation. Surface EMG (Biometrics Ltd) was recorded from surface electrodes over AD and ED muscles. RT was defined as the minimal TMS intensity to recruit an MEP > 50 ?V in five of ten consecutive measurements in both muscles. Measurements were made on three occasions in each participant by the same assessor. Two measurements were carried out on day one with 30 minutes rest in between (tests 1 and 2) and the third measurement was carried out three days later (test 3). Mean peak to peak amplitude of five MEPs at RT were analysed using MATLAB.

Results: Twenty participants (10 males and 10 females, mean age of 59.86 years ±11.70SD) completed the study. There was good to excellent reliability of RT for ED and AD between tests 1 and 2 (ICC=0.89 and 0.94 respectively) and tests 1 and 3 (ICC=0.84 and 0.77 respectively). MEP amplitude between tests 1 and 2 had a poor to moderate level of agreement (ICC=0.42 [ED] and 0.53 [AD]) and between tests 1 and 3, moderate to very poor agreement was found (ICC=0.62 [ED] and 0.14 [AD]).

Conclusions: RT and MEP amplitude are regularly used as neurophysiological outcome measures in neurorehabilitation research. Measurement of the RT showed excellent intra-rater and test-retest reliability in healthy adults. Measurement of MEP amplitude at RT of both muscles showed poor to moderate agreement. RT provides less information about changes in cortical excitability, however, our results suggest RT to be a more reliable neurophysiological measurement, which could be included in future neurorehabilitation trials.

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RELIABILITY OF MOTOR EVOKED POTENTIAL RESTING THRESHOLD AND AMPLITUDE OF PROXIMAL AND DISTAL ARM MUSCLES IN HEALTHY ADULTS Abstract.docx - Other
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Published date: May 2016
Venue - Dates: 9th World Congress for Neurorehabilitation, Philadelphia, United States, 2016-05-01 - 2016-05-01
Organisations: Faculty of Health Sciences

Identifiers

Local EPrints ID: 389770
URI: http://eprints.soton.ac.uk/id/eprint/389770
PURE UUID: 3d0c14c5-0161-4ea9-bdc9-77ea66fac81c
ORCID for A.M. Hughes: ORCID iD orcid.org/0000-0002-3958-8206
ORCID for J.H. Burridge: ORCID iD orcid.org/0000-0003-3497-6725
ORCID for M. Warner: ORCID iD orcid.org/0000-0002-1483-0561
ORCID for S. Brown: ORCID iD orcid.org/0000-0001-9646-3285

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Date deposited: 15 Mar 2016 16:56
Last modified: 15 Mar 2024 03:25

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Contributors

Author: L. Tedesco Triccas
Author: A.M. Hughes ORCID iD
Author: J.H. Burridge ORCID iD
Author: A.E. Din
Author: M. Warner ORCID iD
Author: S. Brown ORCID iD
Author: M. Desikan
Author: J.C. Rothwell
Author: G. Verheyden

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