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Standardizing endpoints in perioperative research

Boney, Oliver, Moonesinghe, Suneetha R., Myles, Paul S. and Grocott, Michael P.W. (2016) Standardizing endpoints in perioperative research Canadian Journal of Anaesthesia, 63, (2), pp. 159-168. (doi:10.1007/s12630-015-0565-y). (PMID:26742948).

Record type: Article

Abstract

Measuring patient-relevant, clinically important, and valid outcomes is fundamental to the delivery of high-quality clinical care and to the innovation and development of such care through research. As surgical innovations become more complex and the burden of age and comorbidities in the surgical patient population continues to increase, understanding the benefits and harms of surgical interventions becomes ever more important. Nevertheless, we can understand only what we can adequately describe. Truly collaborative decision-making, delivery of safe effective care, and on-going quality improvement are also critically dependent on reliable valid measurement of patient-relevant and clinically important data. Attempts to describe the full spectrum of outcomes following surgery necessarily entail moving beyond the traditional endpoints of mortality and resource use towards more complex measures of morbidity, patient-reported outcomes, and functional status. Without standardization and consensus to guide the use of increasingly complex and nuanced endpoints, there is a real risk that perioperative research will become embroiled in a mire of inconsistent heterogeneous outcome measures that cannot be meaningfully compared and contrasted between trials or combined within meta-analyses. This would result in limiting the value of the research effort and depriving patients and clinicians of definitive answers. Collaboration in perioperative medicine-whether between institutions or across continents-has enormous potential to improve the value of research output. Standardizing endpoints for outcome measurement is fundamental to maximizing the quality of such collaboration and ensuring the impact of future perioperative research.

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More information

Accepted/In Press date: 11 November 2015
e-pub ahead of print date: 7 January 2016
Published date: February 2016
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 389810
URI: http://eprints.soton.ac.uk/id/eprint/389810
ISSN: 0832-610X
PURE UUID: 15ddf97f-d13d-4dc9-8c74-ed74463f5a7e

Catalogue record

Date deposited: 15 Mar 2016 16:36
Last modified: 17 Jul 2017 19:32

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Contributors

Author: Oliver Boney
Author: Suneetha R. Moonesinghe
Author: Paul S. Myles

University divisions

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