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Measurement of Exercise Tolerance before Surgery (METS) study: a protocol for an international multicentre prospective cohort study of cardiopulmonary exercise testing prior to major non-cardiac surgery

Wijeysundera, Duminda N., Pearse, Rupert M., Shulman, Mark A., Abbott, Tom E.F., Torres, Elizabeth, Croal, Bernard L., Granton, John T., Thorpe, Kevin E., Grocott, Michael P.W., Farrington, Catherine, Myles, Paul S. and Cuthbertson, Brian H. (2016) Measurement of Exercise Tolerance before Surgery (METS) study: a protocol for an international multicentre prospective cohort study of cardiopulmonary exercise testing prior to major non-cardiac surgery BMJ, 6, (3), pp. 1-10. (doi:10.1136/bmjopen-2015-010359). (PMID:26969643).

Record type: Article


Introduction: Preoperative functional capacity is considered an important risk factor for cardiovascular and other complications of major non-cardiac surgery. Nonetheless, the usual approach for estimating preoperative functional capacity, namely doctors’ subjective assessment, may not accurately predict postoperative morbidity or mortality. 3 possible alternatives are cardiopulmonary exercise testing; the Duke Activity Status Index, a standardised questionnaire for estimating functional capacity; and the serum concentration of N-terminal pro-B-type natriuretic peptide (NT pro-BNP), a biomarker for heart failure and cardiac ischaemia.

Methods and analysis: The Measurement of Exercise Tolerance before Surgery (METS) Study is a multicentre prospective cohort study of patients undergoing major elective non-cardiac surgery at 25 participating study sites in Australia, Canada, New Zealand and the UK. We aim to recruit 1723 participants. Prior to surgery, participants undergo symptom-limited cardiopulmonary exercise testing on a cycle ergometer, complete the Duke Activity Status Index questionnaire, undergo blood sampling to measure serum NT pro-BNP concentration and have their functional capacity subjectively assessed by their responsible doctors. Participants are followed for 1?year after surgery to assess vital status, postoperative complications and general health utilities. The primary outcome is all-cause death or non-fatal myocardial infarction within 30?days after surgery, and the secondary outcome is all-cause death within 1?year after surgery. Both receiver-operating-characteristic curve methods and risk reclassification table methods will be used to compare the prognostic accuracy of preoperative subjective assessment, peak oxygen consumption during cardiopulmonary exercise testing, Duke Activity Status Index scores and serum NT pro-BNP concentration.

Ethics and dissemination: The METS Study has received research ethics board approval at all sites. Participant recruitment began in March 2013, and 1-year follow-up is expected to finish in 2016. Publication of the results of the METS Study is anticipated to occur in 2017.

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Accepted/In Press date: 8 December 2015
Published date: 13 March 2016
Organisations: Clinical & Experimental Sciences


Local EPrints ID: 389820
ISSN: 0959-8138
PURE UUID: 28f170b6-a263-435f-8dbd-2dee19145f36

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Date deposited: 16 Mar 2016 09:31
Last modified: 08 Sep 2017 16:32

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Author: Duminda N. Wijeysundera
Author: Rupert M. Pearse
Author: Mark A. Shulman
Author: Tom E.F. Abbott
Author: Elizabeth Torres
Author: Bernard L. Croal
Author: John T. Granton
Author: Kevin E. Thorpe
Author: Catherine Farrington
Author: Paul S. Myles
Author: Brian H. Cuthbertson

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